Primary localized amyloidosis presenting as diffuse amorphous calcified mass in both orbits: case report

Gonçalves, Arthur Lopes; Moritz, Rodrigo Bernal da Costa; Monteiro, Mário Luiz Ribeiro

doi:10.1590/s0004-27492011000500015

Cited by 9 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HFUS is also considered to be a useful tool for the diagnosis and follow-up of calcium deposits, since it has more sensitivity and specificity than X-ray imaging (7). Dystrophic calcification is rarely found in PLCNA, but have been reported in cases of localized amyloidosis of other organs, such as breast (8), eyelid (9) and lungs (10). Thus, PLCNA should be included in the differential diagnosis of subcutaneous nodules with dystrophic calcification, together with other autoimmune connective tissue diseases, such as cutaneous lupus erythematosus, scleroderma or generalized morphoea.…”

Section: Discussionmentioning

confidence: 99%

Dystrophic Calcification in a Patient with Primary Localized Cutaneous Nodular Amyloidosis: An Uncommon Ultrasound Finding

Planas-Ciudad¹,

Crespo²,

Mir-Bonafé³

et al. 2018

Acta Derm Venerol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Dystrophic Calcification in a Patient with Primary Localized Cutaneous Nodular Amyloidosis: An Uncommon Ultrasound Finding

Planas-Ciudad¹,

Crespo²,

Mir-Bonafé³

et al. 2018

Acta Derm Venerol

View full text Add to dashboard Cite

show abstract

“…(6,7) Calcified orbital lesions are described in metastatic tumors of the orbit, meningioma, teratoma, neurofibroma, sclerosing hemangioma, chondrosarcoma and amyloidosis. (8) …”

Section: Discussionmentioning

confidence: 99%

Isolated primary amyloidosis of the inferior rectus muscle mimicking Graves’ orbitopathy

Monteiro

Gonçalves

Bezerra

2016

Einstein (São Paulo)

Self Cite

View full text Add to dashboard Cite

The diagnosis of Graves’ orbitopathy is usually straightforward. However, orbital diseases that mimick some clinical signs of Graves’ orbitopathy may cause diagnostic confusion, particularly when associated to some form of thyroid dysfunction. This report describes the rare occurrence of localized inferior rectus muscle amyloidosis in a patient with autoimmune hypothyroidism, who was misdiagnosed as Graves’ orbitopathy. A 48-year-old man complained of painless progressive proptosis on the left side and intermittent vertical diplopia for 6 months. The diagnosis of Graves’ orbitopathy was entertained after magnetic resonance imaging revealing a markedly enlarged, tendon-sparing inferior rectus enlargement on the left side, and an autoimmune hypothyroidism was disclosed on systemic medical workup. After no clinical improvement with treatment, the patient was referred to an ophthalmologist and further investigation was performed. The presence of calcification in the inferior rectus muscle on computed tomography, associated with the clinical findings led to a diagnostic biopsy, which revealed amyloid deposition. This report emphasizes that a careful evaluation of atypical forms of Graves’ orbitopathy may be crucial and should include, yet with rare occurrence, amyloidosis in its differential diagnosis.

show abstract

“…[ 53 ] Calcifications that occur in EOMs suggest several pathological entities including orbital metastasis, longstanding orbital inflammation, meningioma, amyloidosis, and neurofibromatosis. [ 54 ]…”

Section: Diagnosis Of the Extraocular Muscle Enlargementmentioning

confidence: 99%

Review article: Diagnosis and management of enlarged extraocular muscles

Abouelatta,

Shalaby,

Awara

et al. 2022

Taiwan Journal of Ophthalmology

View full text Add to dashboard Cite

Extraocular muscle (EOM) enlargement may be due to a variety of causes. These causes can be classified in three ways: according to pathogenesis and histopathological features, according to the site, and according to the clinical features. Diagnosis of the cause is dependent upon history, clinical examination, and investigations. Imaging with computed tomography or magnetic resonance imaging and muscle biopsy is typically necessary to make the correct diagnosis. Treatment of the patient must be directed toward the specific cause. This review emphasizes important clinical and pathological guidelines for appropriate diagnosis and treatment of patients with EOM enlargement.

show abstract

Primary localized amyloidosis presenting as diffuse amorphous calcified mass in both orbits: case report

Cited by 9 publications

References 10 publications

Dystrophic Calcification in a Patient with Primary Localized Cutaneous Nodular Amyloidosis: An Uncommon Ultrasound Finding

Dystrophic Calcification in a Patient with Primary Localized Cutaneous Nodular Amyloidosis: An Uncommon Ultrasound Finding

Isolated primary amyloidosis of the inferior rectus muscle mimicking Graves’ orbitopathy

Review article: Diagnosis and management of enlarged extraocular muscles

Contact Info

Product

Resources

About