Primary Localized Cutaneous Nodular Amyloidosis Presenting as Milia: An Unusual Clinical Manifestation

Abstract

Primary localized cutaneous nodular amyloidosis (PLCNA) is rare and clinically noncharacteristic, presenting mostly as plaque-like lesions. We report a case of a progressively larger erythematous plaque following a contusion of the skin on the right zygomatic area, which was strangely covered with recurrent scattered 2 mm whiteish blisters to the extent that it was misdiagnosed as a herpesvirus infection several times over a decade. Pathology and special staining diagnosed nodular amyloidosis with milia.

Localized Cutaneous Nodular Amyloidosis: A Specific Cutaneous Manifestation of Sjögren’s Syndrome

“…PLCNA manifests as single or multiple waxy, firm, pink, yellowish, or purplish plaques or nodules ( Figure 1 ). Atypical presentations mimicking lymphatic malformation, milia, or bullous disease have also been reported [ 12 , 13 , 14 ]. PLCNA lesions are most commonly found on the acral region, head and neck, and extremities.…”

Localized Cutaneous Nodular Amyloidosis in a Patient with Sjögren’s Syndrome

“…It is not uncommon for the lesions to have a purpuric appearance, and sometimes, telangiectasias are seen on the surface. Atypical presentations simulating a lymphatic malformation [3], milia [4] or a bullous disease [5] have also been reported. PLCNA lesions may be single or multiple and most commonly occur in the acral region, head, neck and extremities [6].…”