Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report

Abstract

Primary skin amyloidosis is a chronic skin disease in which amyloid deposits in the normal skin tissues without involving other organs. At present, the causes and mechanisms of morbidity have not been fully elucidated. There are few clinical reports of nodular skin amyloidosis, and the domestic reports are mostly limited cases. This study reported a rare case of a 46-year-old woman with primary localized cutaneous nodular amyloidosis (PLCNA). The patient presented with features of lymphatic malformation, a plexiform nodule of small blisters. Histological examination revealed amyloid deposits involving the superficial and deep dermis with a small number of plasma cells. Further examinations did not reveal evidence of systemic involvement, indicating a PLCNA. The presentation as lymphatic malformation lesions illustrates the importance of clinical pathology. Nodular amyloidosis typically manifests as single or multiple yellow-brown nodules or plaques of a few millimeters to several centimeters. The center of the nodule sometimes shows atrophy and relaxation or forms a bullous. It is recommended to perform a pathological examination to confirm the diagnosis to distinguish it from lymphatic malformation.

Nail Amyloidoma: Two Case Reports of a New Entity

“…It mainly occurs between the ages of 40 and 60, and there is no gender difference [12,15]. It is found more frequently among Asians, South Americans, and Middle Easterners [12]. Histopathological features of the nodules of both of our patients were also similar to those observed in cutaneous amyloidomas.…”

“…Cutaneous amyloidoma usually presents clinically as single or multiple pink to brown nodules or plaques affecting predominantly the skin of the face, extremities, and genitals [12][13][14]. It mainly occurs between the ages of 40 and 60, and there is no gender difference [12,15]. It is found more frequently among Asians, South Americans, and Middle Easterners [12].…”

Localized Cutaneous Nodular Amyloidosis: A Specific Cutaneous Manifestation of Sjögren’s Syndrome

“…PLCNA manifests as single or multiple waxy, firm, pink, yellowish, or purplish plaques or nodules ( Figure 1 ). Atypical presentations mimicking lymphatic malformation, milia, or bullous disease have also been reported [ 12 , 13 , 14 ]. PLCNA lesions are most commonly found on the acral region, head and neck, and extremities.…”

Helicobacter pylori associated primary cutaneous nodular amyloidosis improvement through debulking and cauterization

“…Nodular amyloidosis, derived from immunoglobulin light chains (amyloidosis light chain proteins) produced by plasma cells infiltrating the skin without associated plasma cell dyscrasia, is the least frequent subtype with only 60 cases reported. 1 , 2 Literature suggests possible associations between primary cutaneous nodular amyloidosis (PCNA), autoimmune disease, and trauma. 2 , 3 Stigall et al reported an association between infection and PCNA.…”

“…1 , 2 Literature suggests possible associations between primary cutaneous nodular amyloidosis (PCNA), autoimmune disease, and trauma. 2 , 3 Stigall et al reported an association between infection and PCNA. 3 Herein, we report the second case of PCNA associated with an infection, specifically Helicobacter pylori .…”