Primary low-grade B-cell lymphoma of MALT-type occurring in the liver: a study of two cases

Maes, M.; Depardieu, C; Dargent, Jean‐Louis; Hermans, Marie; Verhaeghe, Jean-Luc; Delabie, Jan; Pittaluga, Stefania; Troufléau, P.; Verhest, Alain; Wolf-Peeters, Christiane De

doi:10.1016/s0168-8278(97)80332-7

Cited by 63 publications

(28 citation statements)

References 36 publications

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“…the sole genetic abnormality. 27 We therefore investigated the 4 hepatic MALT lymphomas for BCL6 rearrangement by FISH but did not find evidence for BCL6 translocation (not shown).…”

Section: Malt Lymphomas Harboring the T(14;18)(q32;q21) Have Additionmentioning

confidence: 99%

T(14;18)(q32;q21) involving IGH andMALT1 is a frequent chromosomal aberration in MALT lymphoma

Streubel

Lamprecht

Dierlamm

et al. 2003

Blood

456

277

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T(11;18)(q21;q21) is the most common structural abnormality in extranodal marginal zone B-cell lymphoma of mucosaassociated lymphoid tissue (MALT lymphoma) leading to the fusion of the apoptosis inhibitor-2 (API2) gene and the MALT lymphoma-associated translocation (MALT1) gene. In 2 patients with MALT lymphoma of the liver and skin, respectively, t(14;18)(q32;q21) was observed by cytogenetic analysis. Subsequent fluorescence in situ hybridization (FISH) studies disclosed that the immunoglobulin heavy-chain locus (IGH) and the MALT1 gene were rearranged by this translocation. In order to screen a large series of MALT lymphomas for this aberration, a 2-color interphase FISH assay was established. Among a total of 66 cases, t(14;18)(q32;q21) involving IGH and MALT1 was detected in MALT lymphomas of the liver (4 of 4), skin (3 of 11), ocular adnexa (3 of 8), and salivary gland (2 of 11), but did not occur in MALT lymphomas of the stomach (n ‫؍‬ 10), intestine (n ‫؍‬ 9), lung (n ‫؍‬ 7), thyroid (n ‫؍‬ 4), or breast (n ‫؍‬ 2). In total, 12 of 66 (18%) MALT lymphomas harbored t(14;18)(q32; q21); 7 additional cases of splenic marginal zone lymphoma tested negative. All of the 12 MALT lymphomas featuring the t(14;18)(q32;q21) were negative for t(11; 18)(q21;q21) by reverse transcriptasepolymerase chain reaction (RT-PCR). However, trisomy 3 and/or 18 was found in 4 of 12 cases, suggesting that the t(14;18)(q32;q21) does not occur as the sole genetic abnormality. This study identifies IGH as a new translocation partner of MALT1 in MALT lymphomas, which tend to arise frequently at sites other than the gastrointestinal tract and lung. In contrast to t(11;18)(q21;q21) ؉ MALT lymphomas, those with t(14;18)(q32;q21) may harbor additional genetic abnormalities.

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“…the sole genetic abnormality. 27 We therefore investigated the 4 hepatic MALT lymphomas for BCL6 rearrangement by FISH but did not find evidence for BCL6 translocation (not shown).…”

Section: Malt Lymphomas Harboring the T(14;18)(q32;q21) Have Additionmentioning

confidence: 99%

T(14;18)(q32;q21) involving IGH andMALT1 is a frequent chromosomal aberration in MALT lymphoma

Streubel

Lamprecht

Dierlamm

et al. 2003

Blood

456

277

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“…The majority of PHL cases is DLBCL [2,15,20]. Other histologies have been described in less than 5% of cases [15,18,20] and include diffuse lymphoma of the mucosa-associated lymphoid tissue (MALT) type [2,17], mixed small and large cell, lymphoblastic, diffuse immunoblastic, diffuse histiocytic, mantle cell, and small noncleaved or Burkitt lymphoma. The initial misdiagnoses in PHL have been embryonic sarcoma, granulomatous cholangitis, inflammatory pseudotumor, and granulomatous hepatitis [17,21].…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic lymphoma with spindle cell components: a case report

et al. 2006

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Diffuse large B-cell lymphoma (DLBCL) with spindle cell components is extremely rare and often misdiagnosed as carcinoma or sarcoma. Here, we present a case of primary DLBCL with spindle cell components arising in the liver, for which a preoperative diagnosis by needle biopsies was unsuccessful. The patient was a 70-year-old man with a continuous cough. Thoracic computed tomography incidentally detected a mass of 5 cm in diameter in his liver. The initial and second needle biopsies from the liver mass were pathologically diagnosed as suspicious for sarcomatoid hepatocellular carcinoma. He underwent an extended left hepatectomy. Histological examination revealed a diffuse or epithelioid arrangement of round and polygonal cells, mixed with the fascicles of spindle-shaped cells. Immunohistochemically, all the morphological types of tumor cells showed positive reactions for a lymphocytic marker (CD45RB) and B-cell markers (CD20 and CD79a). Double-immunostaining revealed that the spindle-shaped tumor cells expressed CD20, but never expressed alpha-smooth muscle actin. Malignant lymphoma with a spindle cell morphology is quite uncommon, and this variant can be a diagnostic pitfall, especially in tiny biopsy specimens. We emphasize that pathologists should be reminded of lymphoma as a differential diagnosis of spindle cell tumors.

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“…All cases diagnosed as MZBCL between January 1985 and March 1997 at the Department of Pathology of the University of Leuven, in which DNA was available, were investigated (29 of these cases have been included in previous publications (Dierlamm et al, 1996a(Dierlamm et al, , b, 1997. In addition, one case (case 1) was referred from the Department of Pathology, Centre Alexis Vautrin, France (Maes et al, 1997). The diagnosis of MZBCL was established according to the proposed 'revised European-American classification of lymphoid neoplasms' (Harris et al, 1994).…”

Section: Methodsmentioning

confidence: 99%

BCL6 gene rearrangements also occur in marginal zone B‐cell lymphoma

Dierlamm

Pittaluga²,

Stul

et al. 1997

Br J Haematol

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Summary.Marginal zone B-cell lymphoma (MZBCL) represents a distinct subtype of B-cell non-Hodgkin's lymphoma (NHL) which has been recently recognized and defined as a disease entity. Cytogenetically, these lymphomas reveal a high prevalence of trisomy 3, and recent data obtained by comparative genomic hybridization indicate that the chromosomal regions 3q21-23 and 3q25-29 might be of particular pathogenetic significance. We identified structural chromosomal abnormalities involving the region 3q27 and rearrangements of the BCL6 proto-oncogene in three out of 34 (9%) well-defined cases of extranodal, nodal and splenic MZBCL using cytogenetic analysis, Southern blot, and fluorescence in situ hybridization (FISH). All three cases were characterized by a t(3;14)(q27;q32). Two of them showed additional chromosomal abnormalities including trisomy 3, which was found in one case. The patients displayed extranodal disease and did not demonstrate any striking clinical and histological differences when compared with MZBCL lacking BCL6 rearrangement. The present study for the first time demonstrates the occurrence of t(3;14)/BCL6 gene rearrangement in MZBCL, thus suggesting a role of the BCL6 proto-oncogene in the pathogenesis of MZBCL.

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Primary low-grade B-cell lymphoma of MALT-type occurring in the liver: a study of two cases

Cited by 63 publications

References 36 publications

T(14;18)(q32;q21) involving IGH andMALT1 is a frequent chromosomal aberration in MALT lymphoma

T(14;18)(q32;q21) involving IGH andMALT1 is a frequent chromosomal aberration in MALT lymphoma

Primary hepatic lymphoma with spindle cell components: a case report

BCL6 gene rearrangements also occur in marginal zone B‐cell lymphoma

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