Primary lung cancer coexisting with active pulmonary tuberculosis

“…Squamous cell carcinoma was the most common histological subtype in our study (41.2%) that was similar to the studies of Morales-Cardia et al Varol Y et al (22,23). But, adenocarcinoma was the most common subtype in other series (20,24).…”

Section: Discussionsupporting

confidence: 91%

Lung cancer diagnosed with Mycobacterium tuberculosis or nontuberculosis mycobacteria concomitantly

et al. 2017

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“…It is less than that reported by Varol et al where it was seen in 1.1%. 27 Bronchoscopy was the procedure of choice for central tumours and transthoracic FNAB for peripheral tumours in our study. Overall the best diagnostic procedure was transthoracic FNAB (61.2% of all diagnosis).…”

Section: Resultsmentioning

confidence: 77%

A study of the sociodemographic, clinical, pathological and radiological profile of lung cancer in a tertiary care center

et al. 2016

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Background: Lung cancer now constitutes the majority of all cancer diagnosis in the world. It has the most unfavourable prognosis accounting for the maximum number of cancer related deaths worldwide. The objective of this study was to study the complete profile of lung cancer. Prevalence of EGFR mutation in adenocarcinoma. Methods: 116 lung cancer patients were enrolled. They were subjected to diagnostic procedures like transthoracic FNAC/biopsy, bronchoscopy, thoracoscopy, closed pleural biopsy, lymph node FNAC/biopsy, besides routine blood and sputum examinations and CECT thorax. Data was analysed retrospectively after 1 year. Results: Most patients presented in the sixth decade. Mean duration of symptoms was 7.24 months. 62% patients were smokers, 54.3% were exposed to non-smoke tobacco, 18.9% to environmental tobacco smoke (ETS) and biomass fuel. Mass as the single radiological lesion was the most common radiological finding. Pleural effusion was seen in 51.7% patients and was more common in females. Liver (3.4%) and brain (5.9%) were the most common sites of metastasis. EGFR mutation was positive in 34.2% of adenocarcinoma. Exon 19 deletion was more common. ALK was positive in 1 patient. Maximum number of patients (70.7%) presented in stage 4. Transthoracic biopsy could diagnose 61.2% of all lung cancers. Adenocarcinoma was the most common diagnosis (60.3%) and was more common in females and non-smokers. Conclusions: Most patients present in an advanced stage. Adenocarcinoma now seems to be the most common histological subtype of lung cancer in India. EGFR mutation is common in the Indian population. Biomass fuel exposure is a significant risk factor in females. Bronchoscopy is the procedure of choice for diagnosing central tumours and transthoracic FNAC and Biopsy for peripheral tumours.

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“…Conversely, Liang et al found that only adenocarcinoma was significantly associated with TB [6]. Nevertheless, very recent study revealed that the predominant type was still SCC [17]. Though it depends on the regional distribution of lung cancer histology it is rather SCC which is more frequent in TB patients.…”

Section: Discussionmentioning

confidence: 96%

Squamous Cell Lung Cancer in a Male with Pulmonary Tuberculosis

Skowroński¹,

Iwanik

Halicka³

et al. 2015

Advances in Respiratory Medicine

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Lung cancer and pulmonary tuberculosis (TB) are highly prevalent and representing major public health issues. They share common risk factors and clinical manifestations. It is also suggested that TB predicts raised lung cancer risk likely related to chronic inflammation in the lungs. However, it does not seem to influence the clinical course of lung cancer provided that it is properly treated. We present a case report of a 57-year old male with concurrent TB and lung cancer. He was diagnosed with positive sputum smear for acid fast bacilli (AFB) and subsequent culture of Mycobacterium tuberculosis. Besides, his comorbid conditions were chronic hepatitis C virus (HCV) infection and peripheral artery disease (PAD). Later while on anti-tuberculous treatment (ATT) squamous cell lung cancer (SCC) was confirmed with computed tomography (CT) guided biopsy. Due to poor general condition the patient was not fit for either surgery or radical chemo-and radiotherapy. He was transferred to hospice for palliative therapy. We want to emphasize that both TB and lung cancer should be actively sought for in patients with either disorder. In addition, there is no doubt that these patients with lung cancer and with good response to TB treatment should be promptly considered for appropriate anticancer therapy. Case reportThe interaction between lung cancer and tuberculosis (TB) has been long established [1]. There is good evidence that preexisting TB is independently associated with an increased risk of lung cancer [2]. Besides, solid-organ malignancy raises the likelihood of TB reactivation particularly in patients with old healed TB lesions [3].A 57-year old severe underweight (bodymass-index (BMI) 15 kg/m 2 ) male was admitted to a respiratory ward with a history of 3-week long anorexia, fatigue, purulent cough and 1-month long fever. His cough started 6 months before. He reported significant weight loss of 15 kilos for 6 months. He had no chest pain and haemoptysis. As an out-patient he received the course of amoxicillin with clavulanic acid with short-lived improvement. Also, the patient complained of intermittent claudication after a short walking distance. He was a resident of the shelter for homeless for a few years. His primary profession was a garage worker whereas his most recent occupation was garbage sorting. There was a history of heavy smoking (30-pack years) and alcohol addiction. He had not been drinking for last 2 years. He had no evident contact with a confirmed TB source. In the distant past he underwent an ear-nose-throat operation for the nose deformity. On examination, he was undernourished, nor-

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Primary lung cancer coexisting with active pulmonary tuberculosis

Abstract: The present study demonstrates that lung cancer combined with active pulmonary TB most frequently presents as squamous cell carcinoma, with a male predominance. The overall survival of lung cancer patients did not change even with concomitant active TB.

Cited by 19 publications

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Lung cancer diagnosed with Mycobacterium tuberculosis or nontuberculosis mycobacteria concomitantly

Lung cancer diagnosed with Mycobacterium tuberculosis or nontuberculosis mycobacteria concomitantly

A study of the sociodemographic, clinical, pathological and radiological profile of lung cancer in a tertiary care center

Squamous Cell Lung Cancer in a Male with Pulmonary Tuberculosis

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