Primary lymphocytic follicular lymphoma of liver

Torres, Agustin

doi:10.1002/1097-0142(196905)23:5<1185::aid-cncr2820230526>3.0.co;2-n

Cited by 41 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, Torres (Torres, 1969;Torres and Bollozos, 1971), in reporting two cases of primary lymphoma of the liver, states that no previous case had been reported. A thorough review of the literature has revealed only one further case (Ata and Kamal, 1965).…”

Section: Discussionmentioning

confidence: 96%

A case of primary lymphoma of the liver.

Chambers¹,

O’Donoghue²,

Stansfeld³

1976

J Clin Pathol

View full text Add to dashboard Cite

SYNOPSIS A case of primary malignant lymphoma of the liver is described. Presenting with epistaxis, he died in hepatic encephalopathy with an intractable bleeding post-bulbar duodenal ulcer.Although lymphomatous involvement of the liver is common in generalized lymphoma, lymphoma con-fined to the liver is exceptionally rare. Only three previous cases have been documented. The case described here is also unusual in being complicated by bleeding from a post-bulbar duodenal ulcer. Case reportA 55-year-old bank official presented at his local hospital with a severe epistaxis. He gave a six-week history of fatigue, anorexia, and loss of weight. His wife had noticed that at times he was confused and his speech was slurred.In 1945 he had developed malaria. This was treated routinely and there were no recurrences. Splenomegaly was noted at that time. There was no history of excess alcohol intake.On examination there was hepatosplenomegaly and he was admitted for further investigation. Over the next 48 hours he passed both fresh and altered blood per rectum. The prothrombin time and platelet count were normal, but his haemoglobin was 6-3 g/dl. Barium studies showed a post-bulbar duodenal ulcer and possible oesophageal varices. He was transfused 11 units of blood and transferred to St Bartholomew's Hospital.Examination on admission revealed a confused man with a marked flapping tremor and extrapyramidal rigidity. Foetor hepatis was present. There was no bruising of the skin nor petechial haemorrhages. Hepatosplenomegaly was present but there was no lymphadenopathy. None of the stigmata of chronic liver disease was present.Investigations at this time showed a post-transfusion haemoglobin of 13 g/dl, white cell count of 3800 cells/mm3, and a platelet count of 108 000/ mm3. Blood urea and serum electrolytes were normal.Received for publication 23 March 1976 Total protein was 4-4 g/dl, of which 2-3 was albumin. The bilirubin was 2.7 mg/dl, the alkaline phosphatase 575 IU/I, and the serum aspartate aminotransferase was 273 IU/I.It was thought that he had cirrhosis of the liver, and in view of the severity of his liver dysfunction no surgery was undertaken initially. Routine measures to combat hepatic encephalopathy were started but no improvement was noted. Six days after admission he again passed a melaena stool and became clinically shocked. Emergency endoscopy showed that the bleeding was from a post-bulbar duodenal ulcer. Oesophageal varices were not seen.At laparotomy later the same day the ulcer, measuring 2 x 1 cm, was located on the medial aspect of the second part of the duodenum. This was oversewn and a truncal vagotomy and Finney pyloroplasty were performed. The liver had a strange mottled appearance and a wedge biopsy was taken before the abdomen was closed.Postoperatively the patient failed to regain consciousness and continued to lose blood from the gastrointestinal tract. There was no evidence of disseminated intravascular coagulation. He failed to respond to transfusions of fresh blood and fresh frozen plasm...

show abstract

Section: Discussionmentioning

confidence: 96%

A case of primary lymphoma of the liver.

Chambers¹,

O’Donoghue²,

Stansfeld³

1976

J Clin Pathol

View full text Add to dashboard Cite

show abstract

“…Primary follicular lymphoma of the liver has only been reported few times (Torres 1969;Michetti et al 1978;Ryan et al 1988;Ohsawa et al 1992;Lei 1998;Yeshurun et al 2001;Bronowicki et al 2003;Gomyo et al 2007;Raimondo et al 2012). It is estimated that only about 1-4 % of primary hepatic lymphomas are FL (Ohsawa et al 1992).…”

Section: Primary Follicular Lymphoma Of the Hepatobiliary Tractmentioning

confidence: 99%

B-Cell Non-Hodgkin’s Lymphomas with a Small Cell to Intermediate Cell Phenotype

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

View full text Add to dashboard Cite

B-cell non-Hodgkin's lymphomas (B-cell NHLs) showing a proliferation of small-to medium-sized neoplastic cells have a strong tendency to infiltrate the liver. In particular, small lymphoma cells are capable to circulate and recirculate in the body and to leave the microcirculation in several organs. The most common B-cell NHL is chronic lymphocytic leukemia of the B-cell type. In this slowly progressing neoplasia, the liver is almost always involved. Accumulation of neoplastic cells causes hepatomegaly, a typical and frequent finding, with liver weights slowly increasing over time to sometimes reaching several kilograms. The exterior aspect of the liver may become grayish white, and the cut surface shows numerous small whitish nodules. The histologic substrate is markedly enlarged portal tracts which are densely infiltrated by small neoplastic lymphocytes. In long-standing disease, larger nodular lesions can develop, mimicking metastatic disease. A similar type of liver involvement is seen in the rare B-cell prolymphocytic leukemia. Focal and nodular hepatic infiltration is also observed in follicular NHL, mantle cell lymphoma, and extranodal marginal zone B-cell NHL of mucosa-associated lymphoid tissue/MALT. Chronic B-Cell Lymphocytic Leukemia (Small B-Cell Lymphocytic Lymphoma; B-CLL/SLL) ICD-O code 9823/3 play a role for the survival of follicular neoplastic B cells (Amé-Thomas et al. 2012).

show abstract

“…Primary lymphomas of the liver are notably rare 1,2 , and as a result in the past, and even quite recently, they have been diagnosed only at postmortem examination [3][4][5] .…”

mentioning

confidence: 99%

Primary lymphoma of the liver treated by extended hepatectomy and chemotherapy: a case report

et al. 2002

View full text Add to dashboard Cite

Primary lymphoma of the liver is an extremely rare entity. A case of anaplastic large B-cell (both CD-20 and lambda positive) non-Hodgkin's lymphoma that was confined to the liver in a 33-year-old man is reported. The patient was treated with an extended right hepatectomy and combination chemotherapy: cyclophosphamide, adriamycin, vincristine, and prednisone.The patient was disease free 24 months after the procedure.

show abstract

Primary lymphocytic follicular lymphoma of liver

Abstract: A case of primary lympocytic follicular lymphoma of the liver is described. The gross and microscopic features of this tumor are consistent with the diagnosis of lymphocytic lymphoma with follicular pattern.

Cited by 41 publications

References 7 publications

A case of primary lymphoma of the liver.

A case of primary lymphoma of the liver.

B-Cell Non-Hodgkin’s Lymphomas with a Small Cell to Intermediate Cell Phenotype

Primary lymphoma of the liver treated by extended hepatectomy and chemotherapy: a case report

Contact Info

Product

Resources

About