Primary lymphoepithelioma-like carcinoma of minor salivary gland: A case report with immunohistochemical and in situ hybridization studies

Lu, Sheng-Yun; Huang, Chao‐Cheng; Hsiung, Ching-Yeh; Eng, Hock‐Liew; Huang, Hsuan‐Ying

doi:10.1002/hed.20312

Cited by 18 publications

(8 citation statements)

References 13 publications

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“…Among these, LMP-1 has a driving role. Expression of LMP-1 prevents apoptosis, induces abnormal cell proliferation, deregulates epithelial growths and inhibits differentiation, with the epithelial cells showing the features of transformed cells [34]. However, the expression of this protein was observed only in few EBV-linked salivary LELC from Asian patients and our case is the first one in which LMP-1 positivity was detected in a Western patient.…”

Section: Discussionmentioning

confidence: 75%

Lymphoepithelial-like carcinoma of the parotid gland: a case report and a brief review of the western literature

et al. 2013

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BackgroundPrimary lymphoepithelial-like carcinoma of the parotid gland is a rare tumour with an increased incidence among Eskimos and Orientals. In these populations, it is usually associated with Epstein-Barr virus. In Western countries, salivary gland lymphoepithelial-like carcinomas are uncommon and only 14 cases have been described so far; among these, only five cases showed Epstein-Barr virus positivity.Case reportA 45-year-old woman was admitted to Siena Hospital for evaluation of a pre-existent (2 years) painless and tender submandibular mass, rapidly enlarging since two months. On physical examination, a 2.5-cm mass was found in the right parotid. It was firm, mobile and non-tender. Laboratory data were within reference range. Nuclear magnetic resonance detected a 2,5×1,5×1-cm well-circumscribed mass in the deep lobe of the right parotid. A total right paroditectomy with dissection of a satellite lymph node was performed. On the basis of morphological, immunohistochemical and molecular biology findings, a diagnosis of stage II (according to TNM7) Epstein Barr-virus positive, undifferentiated lymphoepithelial-like carcinoma of the parotid gland was made. Twenty months after surgery the patient was free of disease.ConclusionsFurther studies seem to be necessary to completely elucidate the oncogenic role of Epstein Barr-virus in these tumors, which have identical morphology but different prognosis and variable presence of the virus.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1260381551000616

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Section: Discussionmentioning

confidence: 75%

Lymphoepithelial-like carcinoma of the parotid gland: a case report and a brief review of the western literature

et al. 2013

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“…The implication with EBV, since EBV was isolated in >90% of endemic PLEC patients, has proposed a possible function for the virus in the etiopathogenesis of PLEC but the association remains in dispute, taking consideration that EBV usually was undetected in the non-endemic PLEC cases 27 . Additional research papers investigating PLEC neoplasms, reported viral presence in clonal episomal form and viral LMP-1 oncoprotein expression, supporting EBV role in PLEC tumorigenesis 35,36 . Moreover in support of PLEC and EBV association, it has been suggested that EBV is possible to play a role in younger patients in Asian populations, because it was previously reported that primary infection of EBV in children of families with lower socioeconomic status was an early event 37 .…”

Section: Discussionmentioning

confidence: 86%

Primary lymphoepithelial-like carcinoma of the parotid gland-case presentation

Poulopoulos¹,

Parcharidis²,

Nikolaidou³

et al. 2018

Balkan J Dent Med

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SummaryBackground/Aim: Primary Lymphoepithelial carcinoma (PLEC) is a rare subtype of salivary gland cancers, which comprises only 0.4% of salivary malignant neoplasms and only a few cases have been presented previously. Case report: A patient with PLEC of the parotid gland, its management and the available literature are presented. A 53-year-old woman with initial lesion of a lump in the region of the right parotid received treatment with antibiotics which did not lead to improvement. MRI was performed that recorded the presence of a tumor in the right parotid gland and the patient subsequently underwent excision biopsy. The histopathological evaluation together with additional immunohistochemical positive staining of EMA+, EGFR+, p63+, CK 5/6+, AE1/AE3+ established the diagnosis of PLEC. A PET-CT scanning has shown nor primary mucosal source neither skin lesion to account for any possible metastatic disease, consequently a course of adjuvant post-operative radiotherapy to the region of the right parotid gland was performed. Conclusions: In the differential diagnosis of a parotid gland lump should be included the possibility of a rare salivary gland neoplasm such as PLEC. Surgical excision and radiotherapy have been proposed for the treatment of early and advanced neoplasm stages. Ages of the patient, stage of the neoplasm as well as type of therapy are significant and individual variables for the prediction of the prognosis.

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“…In the previous studies, p53 status was studied in only two cases. One case with EBV showed p53 expression in only 25% of the tumor cells, suggesting wild type [5]. In contrast, one EBVnegative LEC showed overexpression of p53 on immunohistochemistry [14].…”

Section: Discussionmentioning

confidence: 93%

Lymphoepithelial Carcinoma in the Lateral Tongue: The Case Report

Ono

Marunaka

Yanai

et al. 2021

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Lymphoepithelial carcinoma (LEC) of the tongue is a rare subtype of squamous cell carcinoma. Histologically, it is an undifferentiated carcinoma with rich lymphocyte and plasma cell infiltration. The most common location for LEC in the head and neck is the salivary glands, and LEC of the oral cavity is extremely rare. The second case report of LEC in the lateral tongue is presented. In addition, a review of the literature was performed, and the relationship between LEC and Epstein–Barr virus infection was considered.

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Primary lymphoepithelioma-like carcinoma of minor salivary gland: A case report with immunohistochemical and in situ hybridization studies

Abstract: Our case suggests potential pathogenic implications of both c-KIT and EBV in LEC of the minor salivary gland that can be cured by the combination of surgery and radiotherapy and has a very favorable long-term prognosis.

Cited by 18 publications

References 13 publications

Lymphoepithelial-like carcinoma of the parotid gland: a case report and a brief review of the western literature

Lymphoepithelial-like carcinoma of the parotid gland: a case report and a brief review of the western literature

Primary lymphoepithelial-like carcinoma of the parotid gland-case presentation

Lymphoepithelial Carcinoma in the Lateral Tongue: The Case Report

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