Primary Lymphoma of Meckel's Cave Mimicking Trigeminal Schwannoma: Case Report

Km, Abdel Aziz; Hr, van Loveren

doi:10.1097/00006123-199904000-00096

Cited by 59 publications

(13 citation statements)

References 15 publications

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“…Occasionally lymphoma or lymphohistiocytic inflammation may spread along the nerve fibers to occupy both the posterior and the middle cranial fossa thereby, mimicking a schwannoma. [15]…”

mentioning

confidence: 99%

Clear cell meningioma masquerading as trigeminal schwannoma

Salunke

Pal²,

Vyas³

et al. 2012

Surg Neurol Int

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“…Occasionally lymphoma or lymphohistiocytic inflammation may spread along the nerve fibers to occupy both the posterior and the middle cranial fossa thereby, mimicking a schwannoma. [15]…”

mentioning

confidence: 99%

Clear cell meningioma masquerading as trigeminal schwannoma

Salunke

Pal²,

Vyas³

et al. 2012

Surg Neurol Int

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“…Two reports described lymphoma arising from Meckel’s cave [6, 7], and some others reported it arising orbitally or in the cavernous sinus [8]. These previously reported skull base lesions have frequently been misdiagnosed as meningiomas or schwannomas, as in the present patient.…”

Section: Discussionmentioning

confidence: 54%

Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge

Ang

Khanna

Walcott

et al. 2015

Journal of Clinical Neuroscience

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We describe an atypical man with diffuse large B cell lymphoma localized to the sphenoid wing and adjacent cavernous sinus, initially presenting with isolated ipsilateral facial pain mimicking trigeminal neuralgia due to invasion of Meckel’s cave but subsequently progressing to intra-axial extension and having synchronous features of systemic lymphoma. Primary central nervous system lymphoma is uncommon, accounting for approximately 2% of all primary intra-cranial tumors, but its incidence has been steadily increasing in some groups [1]. It usually arises in periventricular cerebral white matter, reports of lymphoma in extra-axial regions are rare [2]. This man highlights the importance of maintaining lymphoma in the differential diagnosis of tumors of the skull base presenting with trigeminal neuralgia-like symptoms.

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“…3,17,26,38,40,72 Six were described as small lymphocytic lymphoma 13,14,73,74 or B-cell lymphoproliferative disorder of CLL type, 75 but the four of these that were described prior to the establishment of the REAL-WHO criteria may have actually been MALT/Marginal zone lymphoma since immunophenotypical analysis was not performed. 15,74 The remaining 5 cases were described in various ways, including large-cell immunoblastic T-cell lymphoma, 14 monocytoid malignant B-cell lymphoma, 76 centroblastic/ centrocytic lymphoma, 19 precursor B-cell lymphoblastic lymphoma, 77 and diffuse large cell non-Hodgkin lymphoma due to Richter's transformation. 39 Of the cases of dural MALT lymphoma/MZL, 63 (94%) were isolated to the CNS, while only 4 (6%) were associated with extra-CNS disease at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Dural MALT Lymphoma with Disseminated Disease

Matmati

Hannun

et al. 2010

Hematology Reports

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Central nervous system (CNS) lymphoma involving the dura mater is very rare and histologically is usually a subtype of non-Hodgkin's lymphoma (NHL) termed mucosa-associated lymphoid tissue (MALT) lymphoma. We present a case of a 46-year old woman with dural MALT lymphoma that was found to also involve a lacrimal gland, inguinal lymph nodes, and bone marrow. Magnetic resonance imaging of the brain showed an extra-axial enhancing mass approximately 6 cm in maximum diameter along the right frontotemporal convexity. Histopathology of the resected dural mass showed MALT lymphoma expressing CD20, CD52, CD19, and CD38. Molecular studies of the B-cell receptor heavy chain demonstrated monoclonality at the involved sites. The patient was treated with four cycles of fludarabine, mitoxantrone, and rituximab with complete remission. She had recurrence in the subcutaneous tissue of the back at 12 months but has remained free of intracranial disease for 31 months. A review of the literature reveals 57 cases of dural MALT lymphoma. Only 4 had extra-CNS involvement at presentation, and only 3 had local recurrence of the dural tumor. Because of the indolent behavior of this tumor, the intracranial portion can be treated conservatively after resection with or without chemotherapy. Deferral of brain radiation can be considered with close clinical and neuroimaging follow up.

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Primary Lymphoma of Meckel's Cave Mimicking Trigeminal Schwannoma: Case Report

Cited by 59 publications

References 15 publications

Clear cell meningioma masquerading as trigeminal schwannoma

Clear cell meningioma masquerading as trigeminal schwannoma

Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge

Dural MALT Lymphoma with Disseminated Disease

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