Primary lymphoma of the breast

Wiseman, Charles L.; Liu, Kun

doi:10.1002/1097-0142(197206)29:6<1705::aid-cncr2820290640>3.0.co;2-i

Cited by 433 publications

(300 citation statements)

References 4 publications

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“…As no definite pathologic features distinguish breast from other extranodal sites of lymphoma, their description appears to be preeminent for evaluation and specifically targeting treatment of the tumor site [7]. The specific criteria for PBL diagnosis include:…”

Section: Introductionmentioning

confidence: 99%

Primary Breast Lymphoma with Unconventional Presentation: A Case Report

Nisar¹,

Khan²,

Nisar³

et al. 2017

J Leuk

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Primary breast lymphoma (PBL) is a unique clinical finding accounting for 0.4-0.5% of all neoplasms in breast with a painless palpable mass being a most common presentation. On histopathological findings and radiological imaging, Diffuse large B-cell lymphoma (DLBCL) is the most widespread identifiable type of PBL. We report a case who presented with Primary breast lymphoma having multiple metastatic lesions in lymph nodes, muscles and bones.

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Section: Introductionmentioning

confidence: 99%

Primary Breast Lymphoma with Unconventional Presentation: A Case Report

Nisar¹,

Khan²,

Nisar³

et al. 2017

J Leuk

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“…[1][2][3][4][5][6][7][8][9][10][11][12] Clinicopathologic characteristics of primary breast lymphoma have been well investigated to date. Almost all primary breast lymphoma has a B-cell phenotype, while primary breast lymphoma with T-cell phenotype is extremely rare.…”

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confidence: 99%

Primary breast diffuse large B-cell lymphoma shows a non-germinal center B-cell phenotype

et al. 2005

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Primary breast diffuse large B-cell lymphoma has a poor prognosis relative to other extranodal diffuse large Bcell lymphoma. Recently, diffuse large B-cell lymphoma has been subclassified as germinal center B-cell-like and nongerminal center B-cell types using tissue microarrays. The 5-year overall survival rate of the germinal center B-cell group is better than that of the nongerminal center B-cell group. To elucidate the reason for which primary breast diffuse large B-cell lymphoma has a poor clinical outcome, we investigated 15 patients with primary breast diffuse large B-cell lymphoma (stage IE; 13 cases, stage IIE; two cases) by immunohistochemistry using various markers including CD10, Bcl-6, MUM1 and MIB-1 and by molecular analysis of the immunoglobulin heavy chain gene variable region. Immunohistochemistry showed 0/15 (positive cases/ examined cases) for CD10, 5/15 for Bcl-6, 15/15 for MUM1, 10/15 for Bcl-2, 2/15 for CD5 and 4/15 for CD40. The expression pattern of CD10(À) MUM1( þ ) in primary breast diffuse large B-cell lymphoma corresponded to the nongerminal center B-cell group. Moreover, the MIB-1 index was distributed from 60 to 95% with a mean of 79%, indicating a high proliferation of the lymphoma cells. The immunoglobulin heavy chain gene variable region of primary breast diffuse large B-cell lymphoma had a mutation frequency of 1-10% (seven cases) and 0-1 additional mutations in ongoing mutation analysis (five cases). Primary breast diffuse large B-cell lymphoma had characteristics of the nongerminal center B-cell group. In conclusion, primary breast diffuse large B-cell lymphoma has a nongerminal center B-cell phenotype and has a high MIB-1 index. These features might therefore be associated with poor prognosis.

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“…Diagnostic criteria include involvement of breast and lymphoid tissue in the tumor, negative history of extra-mammary lymphoma, absence of extensive lymphoma involvement, and the breast as the primary region of involvement [9]. The presented case had simultaneous pathological breast and lymphoid tissue involvement.…”

Section: Discussionmentioning

confidence: 88%

Primary Breast Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Transformation to Diffuse Large B-cell Lymphoma: A Case Report

Arslan¹,

Üyetürk²,

Tekgündüz³

et al. 2012

Turk J Hematol

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Primary non-Hodgkin's lymphoma (NHL) of the breast constitutes 0.04%-0.53% of all malignancies and 2.2% of extra nodal lymphomas. In total, 7%-8% of all B-cell lymphomas are the mucosa-associated lymphoid tissue (MALt) type, of which up to 50% of primary gastric MALt lymphoma. Herein we present a patient with breast MALt lymphoma that transformed to diffuse large B-cell lymphoma (DLBCL). A 69-year-old female presented with a mass on her left breast. Physical examination showed a 3 × 3-cm mass located 1 cm from the areola on the upper lateral quadrant of the breast at the 1 o'clock position, which was fixed and firm. excisional biopsy was performed and pathologic examination of the specimen showed MALt lymphoma transformation to DLBCL. the patient was staged as II-eA. the rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (r-CHOP) protocol was scheduled as treatment. Following 6 courses of r-CHOP, 2 additional courses of rituximab were administered. Positron emission tomography (Pet)-Ct was done at the end of the treatment. Pet showed that the patient was in complete remission. At the time this report was written, the patient was being followed-up at the outpatient clinic on a regular basis. Lymphoma of the breast is a rarity among malignant tumors of the breast. the most common type of lymphoma is DLBCL. Breast MALt lymphoma is extremely rare. Primary MALt lymphoma of the breast can transform from low grade to high grade and recurrence is possible; therefore, such patients should be monitored carefully for transformation.key Words: Primary breast mucosa-associated lymphoid tissue (MALt) lymphoma, Diffuse large B-cell lymphoma ÖzetMemenin primer non-Hodgkin lenfomaları (NHL), meme dokusu malignitelerinin %0.04-0.53'ünü; ekstranodal lenfomaların ise %2.2'sini oluşturmaktadır. B hücreli lenfomaların %7-8'ini mukoza ilişkili lenfoid doku (mucosaassociated lymphoid tissue-MALt) tipi lenfomalar, bunların da %50'den fazlasını primer gastrik MALt lenfomalar oluşturmaktadır. Burada memede nadir görülen MALt lenfoma zemininde diffüz büyük B hücreli lenfomaya (DBBHL) dönüşen bir olgunun sunulması amaçlanmıştır. Sol memede şişlik şikayeti ile başvuran 69 yaşındaki kadın hastanın

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Primary lymphoma of the breast

Cited by 433 publications

References 4 publications

Primary Breast Lymphoma with Unconventional Presentation: A Case Report

Primary Breast Lymphoma with Unconventional Presentation: A Case Report

Primary breast diffuse large B-cell lymphoma shows a non-germinal center B-cell phenotype

Primary Breast Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Transformation to Diffuse Large B-cell Lymphoma: A Case Report

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