Primary lymphoma of the cervix: Unusual location for a common disease

González-Cejudo, Carmen; Martínez-Maestre, María Ángeles; Peregrín-Álvarez, Irene; Daza-Manzano, Cinta

doi:10.1016/j.ejogrb.2005.09.020

Cited by 6 publications

(5 citation statements)

References 3 publications

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“…Unfortunately, diagnosis of primary diffuse large B‐cell lymphoma of the cervix is difficult and often delayed because of the rarity of the disease and the absence of specific clinical symptoms. Frequently the clinical picture of patients presenting with these tumors is not specific enough to set an accurate diagnosis and a biopsy is often necessary 7 . This type of tumor is rarely diagnosed by cervical smears, as its origin is in the cervical stroma and the overlying squamous epithelium is usually unaffected 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Frequently the clinical picture of patients presenting with these tumors is not specific enough to set an accurate diagnosis and a biopsy is often necessary. 7 This type of tumor is rarely diagnosed by cervical smears, as its origin is in the cervical stroma and the overlying squamous epithelium is usually unaffected. 8 In the rare occasions where malignancy may be identified through cytology, it has to be necessarily confirmed by histological examination, and sometimes repeated biopsies may be needed to confirm the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Rare case of uterine cervix lymphoma with spontaneous regression: Case report

Desana

Mussetto

Macera

et al. 2020

J of Obstet and Gynaecol

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Primary malignant lymphoma rarely occurs in the female reproductive tract, because of that they are often misdiagnosed. Lymphoma spontaneous regression is even rarer, but it is possible behavior of this disease. A case of 54‐year‐old female patient with a primary diffuse large B‐cell lymphoma of the cervix is presented. First assumption was sarcoma or atypical adenocarcinoma; biopsies have been inconclusive and, after a partial spontaneous regression, diagnosis of lymphoma was possible only after surgery. The diagnosis was a real challenge for clinicians, radiologists and pathologists for both localization and behavior. Difficulties in diagnosis led to an over‐treatment: a laparotomic bilateral hysteron salpingectomy with lymphadenectomy was performed, while chemotherapy alone would have been the right approach. Considering that prognosis and treatment of primary malignant lymphoma of the cervix are completely different than those of other malignant tumors of the uterus, this disease should be considered in the differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rare case of uterine cervix lymphoma with spontaneous regression: Case report

Desana

Mussetto

Macera

et al. 2020

J of Obstet and Gynaecol

View full text Add to dashboard Cite

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“…In fact, often the diagnosis of these tumors is not suspected clinically and it is set only after biopsy. [10] Moreover, this type of tumor is rarely diagnosed by cervical smears, as its origin is in the cervical stroma and the overlying squamous epithelium is usually unaffected. [8,9] In the scarce occasions where malignancy could be set through cytology, it has to be necessarily confirmed by histological examination, and even sometimes repeated biopsies may be necessary to confirm the diagnosis, [11] as it happened in our case.…”

Section: Discussionmentioning

confidence: 99%

Primary diffuse large B cell lymphoma of the uterine cervix successfully treated by combined chemotherapy alone

et al. 2017

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Rationale:Primary lymphomas of the uterine cervix are a rare disease. They are often misdiagnosed because of their rarity and because they can be easily confused with a squamous cell carcinoma of the cervix, as they are usually presented as exophytic mass with vaginal bleeding as their most common symptoms. Nevertheless, considering that both the prognosis and the treatment are completely different between them, differential diagnosis should be taken into account.Patient concerns:A case of a 51-year-old woman with a primary diffuse large B-cell lymphoma of the cervix is presented.Diagnoses:Diagnosis of this tumor was a challenge for pathologists and clinicians, as four biopsies were needed to achieve a final diagnosis.Interventions:Patient was successfully treated with combined Rituximab and chemotherapy (R-CHOP) alone.Outcomes:Complete remission, confirmed through biopsy, was reached after six courses of chemotherapy. At 2-years follow up, patient is alive and free of disease.Lessons:Considering that the prognosis and treatment of primary malignant lymphoma of the cervix are completely different than that of the squamous cell carcinoma, awareness of this disease should be considered in the differential diagnosis.

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“…However, there are a few discrete reports of radical surgery followed by chemotherapy for these patients. [9][10][11][12][13] The aim of the present study was to describe the four cases of primary diffuse large B-cell lymphoma of the cervix which were managed at a tertiary care cancer center with conservative multi-disciplinary approach consisting of immunochemotherapy and radiotherapy and to systematically review the english literature regarding various treatment approaches, their treatment outcomes and prognosis of primary aggressive B-cell non-Hodgkin's lymphoma of the cervix. (Figure 2A-D…”

Section: Introductionmentioning

confidence: 99%

“…A conservative approach of combined modality treatment using combination immunochemotherapy followed by consolidative radiotherapy has been the widely practiced treatment. However, there are a few discrete reports of radical surgery followed by chemotherapy for these patients 9‐13 …”

Section: Introductionmentioning

confidence: 99%

Primary diffuse large B cell lymphoma of Uterine Cervix: Treatment outcomes of a rare entity with literature review

et al. 2020

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Background: Primary lymphomas involving the female genital tract are rare, and those arising from cervix are extremely uncommon. They are often misdiagnosed because of their rarity. Methods and cases: The treatment and clinical outcomes of the four cases treated at our institution were compared with the previously published studies. Written informed consent was taken. We highlight four cases of primary diffuse large B-cell lymphoma of cervix treated at our institution with immunochemotherapy and radiotherapy. The mean age was 50 years (range, 39-62 years). Three patients had stage I disease while one had stage II disease. All the patients were in complete remission following treatment with immunochemotherapy and radiation therapy. The average disease free survival was 20 months (range, 8-43 months). None of the patients had any local or systemic relapse. Conclusion: These cases highlight the physicians to be aware of this entity as their management, natural history and prognosis is completely different from squamous carcinomas of the cervix. Surgery should not be attempted in these patients. Immunochemotherapy and radiotherapy results in favorable clinical outcomes.

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Primary lymphoma of the cervix: Unusual location for a common disease

Cited by 6 publications

References 3 publications

Rare case of uterine cervix lymphoma with spontaneous regression: Case report

Rare case of uterine cervix lymphoma with spontaneous regression: Case report

Primary diffuse large B cell lymphoma of the uterine cervix successfully treated by combined chemotherapy alone

Primary diffuse large B cell lymphoma of Uterine Cervix: Treatment outcomes of a rare entity with literature review

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