Primary lymphoma of the liver with bile duct invasion and tumoral occlusion of the portal vein: report of a case

Yoneyama, Fumihiko; Nimura, Yuji; Kamiya, Junichi; Kondo, Satoshi; Nagiro, Masato; Kanai, Masashi; Murakami, Masahiko; Oda, Koji

doi:10.1016/s0168-8278(98)80070-6

Cited by 22 publications

(7 citation statements)

References 16 publications

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“…This case describes an unusual etiology of esophageal variceal bleeding secondary to noncirrhotic portal hypertension from an extensive PVTT caused by an NHL malignancy surrounding the celiac trunk. Current medical literature yields only seven previously reported cases of NHL-associated PVTT, of which four were specifically DLBCL [4][5][6][7][8][9][10]. This makes our case the eighth reported presentation of NHL-associated PVTT in medical literature, and the fifth specifically associated with DLBCL.…”

Section: Discussionmentioning

confidence: 85%

“…This makes our case the eighth reported presentation of NHL-associated PVTT in medical literature, and the fifth specifically associated with DLBCL. Many of these documented cases of NHL PVTT have had great success with CHOP chemotherapy, alone, resulting in PVTT resolution [4,5,7,8]. One of the earliest cases of NHL PVTT from 1996 documented by Irie and colleagues reported no specific patient outcomes [9].…”

Section: Discussionmentioning

confidence: 99%

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A Rare Presentation of Non-Hodgkin’s Lymphoma Presenting With Bleeding Esophageal Varices Secondary to a Malignant Portal Vein Tumor Thrombosis

Sieloff

Garg

Goyal

et al. 2020

Cureus

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A 60-year-old woman presented with six months of abdominal pain, weight loss and diarrhea for which she underwent bidirectional endoscopies that were unremarkable. Over the next two weeks, she developed non-cirrhotic portal hypertension and presented with esophageal variceal bleeding. A diffuse large B-cell lymphoma encircling her celiac axis with a tumor thrombosis of the superior mesenteric, splenic and portal veins was found to be the cause of her portal hypertension. An esophagogastroduodenoscopy (EGD) was performed to control her variceal bleeding. She was started on R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy and after three cycles her symptoms have subsided, and a CT scan has shown shrinking mesenteric lymphadenopathy.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Non-Hodgkin’s Lymphoma Presenting With Bleeding Esophageal Varices Secondary to a Malignant Portal Vein Tumor Thrombosis

Sieloff

Garg

Goyal

et al. 2020

Cureus

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“…Only one case of acinar cell carcinoma has been reported so far [15] (Table 1). Although tumor thrombosis in the portal venous system is rarely recognized in patients with malignant tumors except for HCC, in addition to these pancreatic tumors, a few exceptional malignancies such as gastric cancer [16][17][18][19][20][21][22][23][24], colorectal cancer [4,23,[25][26][27][28][29][30][31], gallbladder cancer [32], renal cancer [33], malignant lymphoma [34][35][36], and malignant melanoma [37] have been reported to develop portal tumor thrombus.…”

Section: Discussionmentioning

confidence: 99%

A case of acinar cell carcinoma of the pancreas that formed extensive tumor thrombus of the portal vein

Igarashi¹,

Shinozaki²,

Mukada

2008

Clin J Gastroenterol

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A 58-year-old man was admitted to our hospital because of anorexia and back pain. He had been previously diagnosed with chronic pancreatitis with blood thrombus of the splenic vein at another hospital. Abdominal ultrasonography and computed tomography revealed a large mass in the body and tail of the pancreas, which directly invaded the stomach and the spleen. Small nodular metastases in both lungs were also detected. Furthermore, tumor thrombus continuously involved the splenic and proximal superior mesenteric vein, main portal vein, and its right intrahepatic branch. A metastatic mass was disclosed in the adjacent liver. The specimens obtained from portal tumor thrombus were histologically compatible with acinar cell carcinoma. Portal tumor thrombus is a rare condition in pancreatic tumors; however, it seems to be important to differentiate tumor thrombus from blood thrombus of the portal vein in order to know the true clinical stage and provide a suitable treatment.

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“…The optimal therapy for PHL remains unknown. In localized and respectable tumours, good long term results have been achieved with surgical extirpation alone or combined with chemotherapy (3,5,6,(39)(40)(41). Multiagent chemotherapy alone seems more appropriate in cases of diffuse infiltration and has led to prolonged remissions in some cases (3)(4)(5)(6).…”

Section: Discussionmentioning

confidence: 99%

Primary Lymphoma of the Liver: A Case Report and Review

Schweiger

Shinder

Rubin

2000

Canadian Journal of Gastroenterology and Hepatology

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The case of a previously healthy man who developed primary non-Hodgkin's lymphoma of the liver is presented. Biopsy confirmed that the tumour was of the diffuse large cell type and was of apparent T-cell origin. The diagnosis of these rare tumours is suggested by the presence of a hepatic mass without lymphadenopathy, splenomegaly or bone marrow involvement, as well as normal carcinoembryonic antigen and alpha-fetoprotein levels. However, histological examination of tissue is essential to confirm the diagnosis. The response to treatment varies, but surgical resection and/or chemotherapy can result in prolonged remissions. The literature on this topic is briefly reviewed.

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Primary lymphoma of the liver with bile duct invasion and tumoral occlusion of the portal vein: report of a case

Cited by 22 publications

References 16 publications

A Rare Presentation of Non-Hodgkin’s Lymphoma Presenting With Bleeding Esophageal Varices Secondary to a Malignant Portal Vein Tumor Thrombosis

A Rare Presentation of Non-Hodgkin’s Lymphoma Presenting With Bleeding Esophageal Varices Secondary to a Malignant Portal Vein Tumor Thrombosis

A case of acinar cell carcinoma of the pancreas that formed extensive tumor thrombus of the portal vein

Primary Lymphoma of the Liver: A Case Report and Review

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