A 3-year old, intact male Doberman pinscher was examined at the Foster Hospital for Small Animals at Tufts University for a 2-week history of stranguria, dyschezia, and weight loss. Ultrasonographically, there was bilateral hydronephrosis, right-sided hydroureter, hepatosplenomegaly, symmetric mild prostatomegaly, and a distended urinary bladder. Fine needle aspirates and biopsies of the prostate yielded a diagnosis of lymphoma. Lymphoma is a rare cause of prostatomegaly in the dog. Sonographic findings are nonspecific; fine needle aspirates or biopsies are needed to ascertain the diagnosis.