Primary Lymphoma of the Small Intestine A. Clinicopathological Study of 119 Cases

Screening for Celiac Disease in Children With Type 1 Diabetes

“…Two of the six patients with celiac disease appeared to have a subclinical form of the illness. In agreement with these findings, a study (45) …”

Autoimmune Disorders and Lymphomas

“…EATL is an aggressive malignancy that, if untreated, leads to death due to multifocal intestinal perforation caused by refractory malignant ulcers. The prognosis of EATL is very poor compared with that of intestinal B cell lymphomas (Domizio et al, 1993). It shows low chemosensitivity, rapid tumour growth and a tendency to dissemination with about 80% of patients experiencing relapse, even after 5 years of follow up, and a 1-and 5-year survival rates of 31-39% and 8-20% respectively (AlToma et al, 2007, Daum et al, 2003.…”

“…Involved-field radiotherapy 35 Gy was indicated in some patients with bulky disease or incomplete resection (Novakovic et al, 2006), but it is used almost exclusively with palliative purposes. Combined treatment modality with debulking surgery followed by systemic anthracycline-containing polichemotherapy, with or without consolidation radiotherapy, showed an ORR of 58%, a 5-year FFS of 3% and a 5-year OS of 20-25% (Domizio et al, 1993, Gale et al, 2000, d'Amore et al, 1994, Morton et al, 1993. Many patients are unable to complete the chemotherapy program and do not receive radiotherapy due to rapid disease progression, poor nutritional and performance status, associated with local and systemic complications (Daum et al, 2003, Gale et al, 2000.…”

Small bowel non-Hodgkin's lymphoma remaining in complete remission by surgical resection and adjuvant rituximab therapy

“…Primary gastrointestinal lymphoma (PGL) accounts for 4-20% of all non-Hodgkin's lymphomas (NHL) [1,2] . The location most frequently involved has been the ileocecal region, followed by small bowel, accounting for 20-40% of PGL [1] .…”

“…The location most frequently involved has been the ileocecal region, followed by small bowel, accounting for 20-40% of PGL [1] . Small bowel lymphoma tends to be annular in the distal ileum, not proximal [2] . Jejunum obstruction in a patient with NHL has been exceptionally described.…”