Primary lymphoma of the upper small intestine

Nasr, Khosrow; Haghighi, Parviz; Bakhshandeh, Kiumars; Haghshenas, M

doi:10.1136/gut.11.8.673

Cited by 39 publications

(8 citation statements)

References 8 publications

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“…Azar (1962) found in the material collected at the American University of Beirout the same frequency of lymphomas (11.9%) as we observed in Shiraz (Barekat, Saidi, and Dutz, 1971). It appears that lymphoma is more frequent in the Middle East than in Europe or North America (Ullmann and Abeshouse, 1932; Gall and Mallory, 1942;Marcuse and Stout, 1950;Rosenberg, Diamond, Jaslowitz, and Craver, 1961;Azar, 1962;Habibi, 1966;Barekat, Saidi, and Dutz, 1971) and that intestinal lymphoma accounts for a significant part of this increase (Azar, 1962;Ramot, Shahin, and Bubis, 1965;Eidelman et al, 1966;Habibi, 1966;Geddon, 1970;Nasr et al, 1970;Barekat et al, 1971).…”

Section: Discussionmentioning

confidence: 99%

“…Sleisenger and his coworkers (1953) suggested that sprue may be a factor favouring the development of lymphoma primarily in the bowel. Many reports linking the two conditions have appeared since (Culver et al, 1959;Gough et al, 1962;Barrett, 1964;Eidelman et al, 1966;Austad et al, 1967;Huntington et al, 1970;Nasr et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

“…Although this disease pattern is relatively frequent amongst the poorer classes of the Middle East (Ramot, Shahin, and Bubis, 1965;Eidelman et al, 1966;Gedeon, 1970;Nasr, Haghighi, Bakhshandeh, and Haghshenas, 1970) none of the series is well enough standardized to permit comparison nor large enough for valid conclusions. Only the cooperative effort of many in an area of high incidence of the condition will permit final clarification of the relationship of sprue to primary intestinal lymphoma.…”

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confidence: 99%

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Intestinal lymphoma and sprue: A systematic approach

Dutz¹,

Asvadi²,

Sadri³

et al. 1971

Gut

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SUMMARY Intestinal lymphoma is frequently associated with sprue-like bowel patterns. A standardized approach to the problem is suggested.Intestinal lymphoma has been subdivided into four groups, depending on the extent of involvement of the anatomical region. Only cases with specific lesions are accepted as primary lymphoma.The villous pattern in 179 cases at necropsy with suitably preserved mucosa was determined to form a normal baseline for comparison with the uninvolved portions of the lymphomatous small bowel. Only 15 % of all small bowel of this random material of children more than 1 year old and adults showed a flattened mucosa.The non-lymphomatous mucosa of 20 cases with definitely primary intestinal reticulum or lymphosarcoma showed severe sprue-like atrophy in 18 (90%). Two cases of intestinal Hodgkin's disease and four cases of gastric lymphoma were associated with regular mucosal patterns.It is concluded that sprue-like villous atrophy of the small bowel is definitely a triggering factor for the development of primary intestinal reticulum cell or lymphosarcoma. A hypothesis for the possible aetiological relationship of these two conditions is discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Intestinal lymphoma and sprue: A systematic approach

Dutz¹,

Asvadi²,

Sadri³

et al. 1971

Gut

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“…in 1968 and since then there have been many reports of the disease, mostly from the Middle East (Rambaud, Bongel and Prost, 1968;Nasr et al, 1970;Doe et al, 1972;Ramot and Hulu, 1975;Kharazmi et al, 1976; press). It is an immunoproliferative disease of the small intestine, resulting in production of abnormal alpha-chain protein, and is associated with diarrhoea, malabsorption, abdominal pain, vomiting and weight loss (Doe et al, 1972;Kharazmi et al, 1976).…”

mentioning

confidence: 99%

“…The disease is more prevalent amongst the under-privileged population and lower age group. Histologically, diffuse infiltration of the lamina propria of the mucosa of the small intestine with plasma cells, or a mixture of lymphocytes and plasma cells, is another characteristic of this disease (Nasr et al, 1970;Rappaport et al, 1972;Kharazmi et al, 1976).…”

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confidence: 99%

T and B lymphocytes in alpha-chain disease

Kharazmi¹,

Rezai²,

Abadi³

et al. 1978

Br J Cancer

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Summary.-The patients studied were diagnosed as suffering from alpha-chain disease by their clinicopathological features, malabsorption findings, X-ray, and presence of abnormal alpha-chain protein in their serum. The objective of the study was to determine any possible defect of the immune system in such patients. The rosette technique and surface immunofluorescence were used to enumerate the circulating T and B lymphocytes in these patients. They were also skin-tested with tuberculin and given sensitizing doses of dinitrochlorobenzene. Their serum immunoglobulins were also quantitated. It was found that the proportion of circulating B lymphocytes was much higher than normal, whereas that of T lymphocytes was lower than normal. Furthermore, they could not be sensitized to DNCB and their skin test to tuberculin was negative. It was concluded that the disease was a B-cell disease of IgA type, associated with low level of cellular immunity.

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Mycosis fungoides. Small-bowel involvement complicated by perforation and peritonitis

Camisa¹

1981

Archives of Dermatology

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Mycosis fungoides (MF) is a malignant lymphoma that arises in the skin and subsequently may involve lymph nodes and viscera as part of the natural course of the disease. The disease has distinct histologic characteristics that may be recognized in extracutaneous tissues. A patient who had MF with ulcerating cutaneous nodules is presented herein. Death resulted from perforation of the small bowel involved by the disease and consequent peritonitis.

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Primary lymphoma of the upper small intestine

Cited by 39 publications

References 8 publications

Intestinal lymphoma and sprue: A systematic approach

Intestinal lymphoma and sprue: A systematic approach

T and B lymphocytes in alpha-chain disease

Mycosis fungoides. Small-bowel involvement complicated by perforation and peritonitis

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