Primary Lymphomas of the Breast: A Review

A Rare Case of Primary Breast Diffuse Large B-cell Lymphoma in an Acquired Immunodeficiency Syndrome Patient

“…Approximately 0.4% of breast cancers are PBLs, in which case the mass arises from the lymphoid tissue [ 5 ]. PBLs can be of different histological subtypes, arising from either B or T cells, with the most common being DLBCL, occurring at a rate of 45% to 79% [ 1 , 6 ].…”

“…Primary breast lymphoma (PBL) is a rare type of extranodal lymphoma, causing only 0.4% of breast cancers [ 1 ]. A diagnostic criterion for PBL was proposed by Wiseman and Liao: 1) the presenting site of the lymphoma should be the breast; 2) there should be no history of lymphoma or signs of widespread disease at the time of diagnosis; 3) the lymphomatous proliferation should be in close relation with breast tissue histologically; and 4) ipsilateral lymph nodes may be involved and be considered as long as they arise simultaneously with the breast mass [ 2 ].…”

Clinical recommendations for diagnosis and treatment according to current updated knowledge on BIA-ALCL

“…Conditions which have been hypothesized as local triggers of chronic inflammation include bacterial contamination, shell shedding of particulates, shell surface friction, and implant-associated reactive compounds [ 28 , [36] , [37] , [38] , [39] ]. Regardless of the primary triggers, chronic inflammation could represent the determining factor driving lymphomagenesis by favoring the accumulation of malignancy-promoting mutations into the chronically stimulated T cells [ [40] , [41] , [42] , [43] , [44] , [45] , [46] ]. To date, there is no general agreement to exclude any of these factors or on how they cooperate in the pathogenesis of BIA-ALCL.…”

A Rare and Isolated Presentation of Primary Cutaneous Anaplastic Large Cell Lymphoma on the Breast

“…While most lesions manifest on the extremities, followed by the head and neck, the breast region may rarely be affected by PC-ALCL. Distinctions between anaplastic lymphoma kinase (ALK)-positive and ALK-negative subtypes have been documented in breast presentations, often associated with breast implants [ 2 ]. In this context, we present an isolated PC-ALCL instance in a 26-year-old woman with no history of breast implants.…”