Primary malignant achromic melanoma of the lung

Lazarou, Ilias; Purek, Lesek; Duc, Christophe; Licker, Marc; Spiliopoulos, Anastase; Tschopp, Jean‐Marie

doi:10.1111/1759-7714.12011

Cited by 11 publications

(8 citation statements)

References 15 publications

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“…Surgical resection combined with immunotherapy, when feasible, is the main treatment for PMML; however, the prognosis for most patients is poor. 4 Lazarou et al 13 reported a case of an 82-year-old male nonsmoker with PMML who underwent total right lung resection. Postoperative rib metastases developed, and radiotherapy was administered, but the clinical response was incomplete, and the patient died 13 months after diagnosis.…”

Section: Discussionmentioning

confidence: 99%

CT and PET/CT findings of primary pulmonary malignant melanoma: a case report and literature review

et al. 2023

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Primary malignant melanoma of the lung (PMML) is an extremely rare and refractory tumor, and its diagnosis is a significant challenge. The current study presents the case of a 62-year-old man who presented to the Department of Cardiothoracic Surgery (Lishui Municipal Central Hospital, Lishui, China) with chest tightness and fatigue for 3 months. Chest computed tomography (CT) revealed a 1.5- × 1.9-cm mass with irregular borders and heterogenous density located in the right lower lung lobe. Contrast-enhanced CT revealed slight enhancement of the mass, but there was no clear evidence of malignancy. Positron emission tomography (PET)/CT revealed a defined-margin mass, with slightly high uptake (standardized uptake value [SUV]: 3.6). The patient underwent video-assisted thoracoscopic surgery (VATS), and the final diagnosis was PMML on the basis of the results of the pathological examination. The patient received four courses of immunotherapy after the operation, and eventually declined further immunotherapy owing to the high cost. The patient was followed-up for 1 year without metastasis or recurrence.

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Section: Discussionmentioning

confidence: 99%

CT and PET/CT findings of primary pulmonary malignant melanoma: a case report and literature review

et al. 2023

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“…During the diagnosis, attention should be paid to distinguishing PMML from some similar tumours such as squamous cell carcinoma (SCC), pulmonary metastatic melanoma (PMM), and pigmented carcinoid tumour (PCT) [15][16][17]. The imaging features of primary MM are similar to those of SCC, especially when the degree of tumour differentiation is low.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the lung: a case report and literature review

et al. 2020

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Background: Malignant melanoma (MM) generally presents as a primary neoplasm of the skin, and most MM cases of the respiratory system are metastatic. Primary MM of the lung (PMML) is quite rare, and its diagnosis is relatively difficult. Case presentation: We report the case of a 57-year-old male patient with PMML who denied any history of tumours. His initial complaint was frequent coughs with bloody sputum for 4 days. Chest radiography demonstrated a highdensity shadow in the lower lobe of the right lung, which was suspected to be a large space-occupying lesion on subsequent computed tomography (CT) and to be a hypermetabolic tumour by positron emission tomography-CT. To confirm the diagnosis, exploratory surgery was performed. Finally, we confirmed the diagnosis of PMML. Conclusions: PMML is extremely rare and easily misdiagnosed as lung cancer. Because of its morphological and immunophenotypic variations, the diagnosis of PMML remains difficult. This case report discusses the diagnosis and case management of a patient while referring to the existing literature.

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“…This approach would be limited in cases of achromatic melanomas so they should be excluded from the category of tumors appropriated for this strategy. A possibility for their inclusion in the one - step melanoma surgery would be the use of confocal microscopy and/or cytological analysis in combination with immunohistochemical methods [ 27 ][ 28 ].…”

Section: Discussionmentioning

confidence: 99%

One Step Melanoma Surgery for Patient with Thick Primary Melanomas: "To Break the Rules, You Must First Master Them!"

Tchernev¹

2018

Open Access Maced J Med Sci

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BACKGROUND:We present to the attention of the medical, dermatological and oncosurgical community data that serves to indicate the indispensability of optimisation of the algorithm and recommendations for diagnosis and surgical treatment of cutaneous melanoma. These recommendations could be referred to different subgroups of patients in different clinical stages as well as to patients with different initial characterisation (histological morphology) of the primary tumours. One step surgery is not a myth, even more, it could prove to be one of the best solutions for some patient collectives with advanced stages of melanoma.CASE REPORT:We present a case of a 74 - year old patient with a congenital medium sized melanocytic nevus, located directly above the lateral part of the elbow joint. In one month and a half, an achromatic nodular formation evolves with a diameter of 2.7 x 2.3 cm, prominent over the skin level, painful by palpation and spontaneously bleeding. By the anamnestic, clinical and dermoscopic findings the patient was diagnosed with nodular melanoma associated with a congenital medium sized melanocytic nevus. A primary excision with a field of safety 0.5 cm in all directions was performed. After confirmation of the primary diagnosis (tumour thickness 8 mm with no ultrasonographic detection of enlarged lymph nodes), seven days later are - excision was performed with an additional field of surgical safety of 1.5 cm in all directions.CONCLUSIONS:In this case remains unclear the following question: For what reason a preoperative high - frequent ultrasonography (HFUS) is not recommended to be used as it will allow only one surgical excision with the elimination of a tumour with a safety field of 2cm in all directions? The enigma about the obstacles preventing such a rational optimisation of the current diagnostic and therapeutic algorithm in patients with melanomas remains unresolved. One step surgery for cutaneous melanoma is widely used in many countries although it continues to be considered as a matter of dispute for some experts. Once again, by a clinical case and the following analysis, we would like to focus the attention of the dermatosurgical community on this crucial and highly significant problem. Innovations are very often resulting from the simplicity of logic, which unfortunately is not always accepted appropriately.

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Primary malignant achromic melanoma of the lung

Cited by 11 publications

References 15 publications

CT and PET/CT findings of primary pulmonary malignant melanoma: a case report and literature review

CT and PET/CT findings of primary pulmonary malignant melanoma: a case report and literature review

Primary malignant melanoma of the lung: a case report and literature review

One Step Melanoma Surgery for Patient with Thick Primary Melanomas: "To Break the Rules, You Must First Master Them!"

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