Primary Malignant Fibrous Histiocytoma of the Ascending Colon: Report of a Case

Ōkubo, H.; Ozeki, Kazuyuki; Tanaka, Toshiro; Matsuo, Takeshi; Mochinaga, Nobuo

doi:10.1007/s00595-004-2915-1

Cited by 18 publications

(18 citation statements)

References 19 publications

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“…Most tumors are large, ranging from 2 cm to 19 cm in diameter (median diameter, 7 cm), and the tumor in our patient is probably one of the smallest tumor observed. The distribution differs from more common types of colorectal cancer [22] . The tumor locations include nine in the right-sided colon, seven in the transverse and descending colon, three in the sigmoid colon, and four in the anorectum.…”

Section: Discussionmentioning

confidence: 80%

Transanal excision of a malignant fibrous histiocytoma of anal canal: A case report and literature review

Kim¹,

Chang²,

Park³

et al. 2008

WJG

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Section: Discussionmentioning

confidence: 80%

Transanal excision of a malignant fibrous histiocytoma of anal canal: A case report and literature review

Kim¹,

Chang²,

Park³

et al. 2008

WJG

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“…As regards the histological and immunohistochemical staining results, MFH is composed of histiocytic as well as fibrous elements, often arranged in a storiform pattern and accompanied by pleomorphic giant cells, xanthoma cells and inflammatory cells (7). It was reported that MFH frequently expresses vimentin, actin, CD68, α 1-antitrypsin and α 1-antichymotrypsin, and often laminin mRNA (10).…”

Section: Discussionmentioning

confidence: 99%

Primary malignant fibrous histiocytoma of the colon: A case report and review of the literature

Zhong

You

et al. 2016

Molecular and Clinical Oncology

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Abstract.A 68-year-old woman was admitted to the Peking Union Medical College Hospital with a 6-week history of fever of undetermined origin. The computed tomography scan revealed a space-occupying lesion in the ascending colon and colonic endoscopy revealed a protrusive lesion in the initial segment of the ascending colon, occupying 3̸5 of the lumen. Pathological examination of a biopsy specimen revealed malignant fibrous histiocytoma (MFH). The patient then underwent a laparotomy for right hemicolectomy and en bloc lymph node dissection. The histopathological examination confirmed the diagnosis of MFH and administration of adjuvant radiotherapy was decided. MFH is a high-grade sarcoma that rarely arises in the alimentary tract. To the best of our knowledge, there has only been one case of primary colorectal MFH treated by radiotherapy recorded to date, which makes our case the second trial. We herein present a case of MFH in the ascending colon and a review of previous case reports of patients presenting with this unusual type of MFH. IntroductionMalignant fibrous histiocytoma (MFH) is a high-grade sarcoma that usually involves the soft tissue of the extremities and the retroperitoneum, but seldom arises in the alimentary tract. Since the late 1970s, <30 cases of colorectal MFH have been documented, whereas little is known on its histogenesis and optimal treatment. MFH is a type of histiocytoma and the most common soft tissue sarcoma of late adult life (5th to 7th decades), accounting for 21% of all soft-tissue sarcomas in a Japanese study of 130 cases (1). The major locations for this tumor are the lower (49%) and upper extremities (19%), while tumors of the retroperitoneum and abdominal cavity account for 16%, and those of head and neck account for 9% of the cases (2). We herein present a case of MFH of the ascending colon and discuss the characteristics of this tumor with reference to the literature. Case reportA 68-year-old woman was admitted to the Peking Union Medical College Hospital in 2009 with a 6-week history of fever of undetermined origin (FUO). There was no recent history of cough, runny nose, pharyngalgia, vomiting or diarrhea. Antibiotic therapy proved ineffective and the patient was repeatedly administered non-steroidal anti-inflammatory drugs to control the temperature. She also exhibited increased nocturia over the past 15 years and a weight loss of 10 kg over the 6-week period of FUO. The patient was of average build and fairly well-nourished. On physical examination, there were no remarkable findings during abdominal palpation; however, 0.5-cm lymph nodes in the right neck and axilla were palpable, without tenderness. Furthermore, the liver border was palpable one finger width below the costal margin. The past medical history and family history were unremarkable.Laboratory tests revealed a white blood cell count of 8.69x10 9 ̸l (neutrophils, 85.5%), hemoglobin concentration of 75 g̸l, platelet count of 552x10 9 ̸l, C-reactive protein (CRP) level of 119 mg̸l and erythrocyte sedimentation ra...

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“…Malignant fibrous histiocytoma (MFH) was first described [3,5] . The peak incidence of extraintestinal MFH occurs in the sixth and seventh decades of life.…”

Section: Discussionmentioning

confidence: 99%

“…Primar y MFH of the intestine is ver y rare. Not more than 40 cases have been reported in international literatures [1][2][3][4] . We reviewed the total 37 cases of intestinal MFH, including ours, and summarized the findings as follow.…”

Section: Discussionmentioning

confidence: 99%

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Primary intestinal malignant fibrous histiocytoma: Two case reports

Fu¹

2007

WJG

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Case 1A 70-year old man was admitted for recurrent right lower quadrant abdominal pain for about 50 d. He had no recent history of fever, vomiting, diarrhea, or constipation. Physical examination revealed a slightly tender fist-size mass in the right lower quadrant of the abdomen. Laboratory examination showed a white blood cell count of 5.02 × 10 9 /L, and a neutrophil count of 68.3%. Abdominal ultrasonography revealed a large hypoechoic mass in the right lower quadrant and an abdominal computed tomography demonstrated a large soft-tissue mass in the right lumbar region and iliac fossa ( Figure 1A). Chest X-ray and computed tomography showed a mass on the hilum of the right lung ( Figure 1B). Barium enema and colonofiberscopy were not performed owing to the patient's abdominal pain. At laparotomy, a tumor was found originating from the cecum and infiltrating into the right lateral peritoneum. There was a suspicious metastatic nodule located on the surface of the right lobe of the liver. A right hemicolectomy was carried out, and reconstruction was performed by an ileotransverse endto-end anastomosis. Grossly, an ulcerative annular tumor undergone necrosis was seen in the cecum, measuring 12 cm × 10 cm. There was a tumor nodule on the mesentery, measuring 3 cm × 2 cm. On cut section, the tumor was soft in consistency, solid and grayish-white in color. Microscopic examination revealed that the tumor was pleomorphic and consisted of spindle-shaped cells, oval cells, pleomorphic giant cells, and inflammatory cells. There were involvements of two lymph nodes. Immunohistochemical stains were positive for vimentin (Figure 2), KP-1, α 1-antitrypsin AbstractMalignant fibrous histiocytoma (MFH) occurs most commonly in the extremities and trunk, but rarely in the intestine. Here we report two cases of primary intestinal MFH. The first case was a 70-year old man admitted for recurrent right lower quadrant abdominal pain. At laparotomy, a tumor was found originating from the cecum, with a suspicious metastatic nodule on the surface of the right lobe of the liver. A right h e m i c o l e c t o m y w a s p e r f o r m e d f o l l o w e d b y a n ileotransverse end-to-end anastomotic reconstruction. T h e s e c o n d c a s e w a s a 4 3 -y e a r o l d m a n w i t h intussusceptions of the small intestine. An emergent laparotomy revealed 4 pedunculated masses in the small bowel and a partial resection of the small intestine was performed. Though the symptoms were not typical, based on histological and immunohistochemical studies, the patients were diagnosed as MFH of the intestine. They were not treated with chemotherapy or radiotherapy and both died within 3 mo. MFH of the intestine is an extremely rare neoplasm with an aggressive biological behavior. The pathogenesis of this disease has not been clarified to date. Complete surgical excision is preferred, adjuvant chemotherapy or radiotherapy may be advisable.

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Primary Malignant Fibrous Histiocytoma of the Ascending Colon: Report of a Case

Cited by 18 publications

References 19 publications

Transanal excision of a malignant fibrous histiocytoma of anal canal: A case report and literature review

Transanal excision of a malignant fibrous histiocytoma of anal canal: A case report and literature review

Primary malignant fibrous histiocytoma of the colon: A case report and review of the literature

Primary intestinal malignant fibrous histiocytoma: Two case reports

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