Primary malignant fibrous histiocytoma of the breast: report of one case

Abstract

Seven years ago, a 48-year-old female patient discovered a painless tumor in her right breast simply by chance. In the next year, the tumor increased significantly in size. At this point, the patient received a tumor resection, which was misdiagnosed as a benign mesenchymal tissue-originated tumor. Unfortunately, the tumor recurred just 10 days after resection. We subsequently resected the recurrent lesion and confirmed primary breast malignant fibrous histiocytoma. The tumor began to exhibit an unprecedented, massive, and uncontrolled growth, ulcerating soon after the operation. Treatment of the patient was limited by time. After the patient received a cycle of chemotherapy, she died of cachexia with the emergence of multiorgan metastasis 2 months after the operation.

Clinical and pathological analysis of 116 cases of adult adrenal cortical adenoma and literature review

“…Only a few reports have been published regarding the pathology of ACA. 5 The differences between malignant and benign adrenal disease, 6 , 7 the characteristics of functioning and non-functioning adenomas, 8 , 9 and the distinction between patients with bilateral and unilateral adrenal incidentalomas 10 have been described, but little is known about the differentiation of adult and pediatric ACAs.…”

Mesenchymal breast lesions

“…44,45 Breast MFH affects middle-aged to elderly females, and less often occurs in elderly males. 44,46,47 On clinical examination, a breast MFH presents as a painless palpable mass that the patient reports appeared over a short time. 44,47 One series of nine patients described the presentation as a painless breast mass in all patients.…”

“…44,46,47 On clinical examination, a breast MFH presents as a painless palpable mass that the patient reports appeared over a short time. 44,47 One series of nine patients described the presentation as a painless breast mass in all patients. 48 Alternatively, cases have also been reported of slowly growing or painful masses.…”

“…48 Alternatively, cases have also been reported of slowly growing or painful masses. 47,49 There is great variability in size, with MFHs in one series reported as ranging from 1.3e15 cm with a mean of 6.3 cm. 46 Palpable axillary lymphadenopathy has been reported and regional lymph node metastases are reported to occur in 12e32% of cases.…”

“…46 Palpable axillary lymphadenopathy has been reported and regional lymph node metastases are reported to occur in 12e32% of cases. 45,47 MFHs are sarcomas made of fibroblast-like and histiocyte-like cells mixed with pleomorphic giant and inflammatory cells. 44,48,50 They contain mesenchymal markers.…”