Primary malignant lymphoma of the cranial vault

Abstract

A 60-year-old woman presented with a subcutaneous mass on her scalp. Computed tomography (CT) showed a homogeneously enhanced mass of the parietal bone with both intra- and extra-calvarial extension and having destroyed the right parietal bone. The mass was hypointense on the T1-weighted magnetic resonance image, slightly hyperintense on the T2-weighted image and homogenously enhanced with Gd-DTPA. Bone scintigraphy showed prominent accumulation of radioisotopes in the scalp lesion. The tumour was removed, including the involved bone and dura mater. Histologic diagnosis was non-Hodgkin's B-cell lymphoma, and tumour cells had infiltrated into the dura mater. The patient was treated with radiotherapy and chemotherapy. She returned to ordinary daily life and has been well without recurrence for 3 years. Although primary malignant lymphoma of the cranial vault is rare, it should be considered in the differential diagnosis when a mass is encountered in the cranial vault. We have found only fourteen such cases in the literature, and we review these cases.

Primary Diffuse Large B-Cell Lymphomas of the Temporoparietal Dura Mater and Scalp Without Intervening Skull Bone Invasion -Case Report-

“…[2][3][4][5][6]10,11,[13][14][15]18,19) In contrast, in our case, the dural and subcutaneous tumors existed independently without intervening skull invasion as confirmed by the preoperative images and surgical findings. Histological diagnosis confirmed these tumors as DLBCLs.…”

Incidence and clinical significance of lesions presenting as a scalp mass in adult patients

“…However, primary lymphoma in the cranial vault is quite rare. The overall reported rate of non-Hodgkin lymphoma originating from bone tissue is 3-4 % [2,3]. Fukushima presented a review reporting 15 cases.…”

Primary Bone Burkitt’s like Lymphoma of the Skull Mimicking Meningioma - Case Report and Review of Literature

“…The clinical presentation was the most commonly seen with skull lymphoma, where most cases reviewed also presented with a scalp lump or swelling [6][7][8][9][10][11][12][13], [15,21,22].…”

“…Our patient was diagnosed at the age of 26, much younger than the median age of this population which was 48 years in 19 similar cases of primary bone lymphoma of the skull which we reviewed [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

“…Most of the cases reviewed were treated with a low intensity chemotherapy regimen similar to CHOP or CEOP with or without Rituximab [7][8][9][10][11][12][13][14][15][16][17][18][19][20] and one case was treated with high dose methotrexate [17].…”