Primary Malignant Lymphoma of the Uterine Corpus Diagnosed by Endometrial Cytology

Ohwada, Michitaka; Suzuki, Mitsuaki; Onagawa, Tamaho; Ishida, Akiko; Kawai, Toshiro; Sato, Ikuo

doi:10.1159/000328595

Cited by 6 publications

(6 citation statements)

References 9 publications

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“…Most primary endometrial lymphomas occur in postmenopausal females, usually in their fifth or sixth decades (23,(34)(35)(36)(37)(38)(39)(40), but occasionally premenopausal women in their 20s or 30s have been affected (23,24). Bleeding was the most common presenting symptom, regardless of cell type and whether it was high grade B-cell lymphoma (23,37,41) or primary T-cell lymphoma (38,39).…”

Section: Endometriummentioning

confidence: 99%

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Lymphoma of the Female Genital Tract: Current Status

Lagoo

Robboy

2006

International Journal of Gynecological Pathology

132

125

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: Primary lymphomas affecting the female reproductive system are uncommon but often pose a diagnostic challenge if their existence is not suspected. This article reviews the pathological and clinical features of lymphomas occurring in various sites in the female genital tract including the vulva, vagina, cervix, endometrium, fallopian tubes, and ovaries. Using the recent World Health Organization classification, the various types of lymphomas are identified as separate diseases and not as morphological variations of the same disease. The immunophenotypic and cytogenetics features of the major lymphomas are summarized. The incidence, presenting symptoms, gross and microscopic features, major differential diagnostic considerations, response to therapy, and expected outcome are discussed. Using published data on patient outcome, the International Federation of Obstetricians and Gynecologists and Ann Arbor staging systems are compared for their predictive value, and the difficulty in assigning primary and secondary status in extranodal lymphomas is emphasized. The observed differences in the behavior of some lymphomas in gynecological sites compared with their usual nodal location are presented. Finally, the possible etiology of these conditions is discussed in light of the emerging paradigm of mucosa-associated lymphoid tissue lymphomas.

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Section: Endometriummentioning

confidence: 99%

“…Bleeding was the most common presenting symptom, regardless of cell type and whether it was high grade B-cell lymphoma (23,37,41) or primary T-cell lymphoma (38,39). Rare cases have been discovered during work-up for cervical dysplasia or in specimens of uterine prolapse (34,40).…”

Section: Endometriummentioning

confidence: 99%

Lymphoma of the Female Genital Tract: Current Status

Lagoo

Robboy

2006

International Journal of Gynecological Pathology

132

125

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Section: Discussionmentioning

confidence: 99%

“…Although extremely rare, malignant lymphoma may be found in endometrial specimens . Lymphoma cells are isolated and scattered in an inflammatory background, and have round, oval, or convoluted nuclei with conspicuous nucleoli . Although both, small‐cell NEC and malignant lymphoma demonstrate a high nuclear/cytoplasmic ratio, the nuclear features and shapes of the neoplastic clusters are different.…”

Section: Discussionmentioning

confidence: 99%

Small‐cell neuroendocrine carcinoma in directly sampled endometrial cytology: A monocentric retrospective study of six cases

Ebisu

Ishida

Okano

et al. 2019

Diagnostic Cytopathology

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Small-cell neuroendocrine carcinoma (NEC) of the endometrium is extremely rare, and demonstrates an aggressive clinical course. Since reports describing its cytological features are scarce, we aimed to retrospectively analyze these features. Patients with a histopathological diagnosis of NEC who underwent preoperative cytological examination, were enrolled in this study. The cytological features including the background, arrangement, and shape of the neoplastic cells, and the nuclear and cytoplasmic features were reviewed; six patients were enrolled. The conventionally stained, directly sampled cytological specimens showed small neoplastic cell clusters in all cases, as well as isolated neoplastic cells and large clusters in 3 and 2 cases, respectively,

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“…Vorlaufer-und reife kleinzellige Lymphome sind vor allem von kleinzelligen neuroendokrinen Karzinomen dem kleinzelligen Karzinom vom hyperkalziimische~ Typ, von Melanomen, Rhabdomyosarkomen, primitiven neuroektodermalen Tumoren, intraabdominalen, desmoplastischen kleinen rundzelligen Tumoren und Neuroblastomen abzugrenzen [107,154,156,256] 100,113,170,181). Auch ki:innen die Tumoren ein diffuses, infiltratives Verhalten zeigen, was u. U. zu einer sichtbaren Formveranderung des Uterus fiihrt [ 88) .…”

Section: Kapitel 37unclassified

Lymphoproliferative Erkrankungen des weiblichen und männlichen Genitaltrakts sowie der Mamma

2018

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Primary Malignant Lymphoma of the Uterine Corpus Diagnosed by Endometrial Cytology

Cited by 6 publications

References 9 publications

Lymphoma of the Female Genital Tract: Current Status

Lymphoma of the Female Genital Tract: Current Status

Small‐cell neuroendocrine carcinoma in directly sampled endometrial cytology: A monocentric retrospective study of six cases

Lymphoproliferative Erkrankungen des weiblichen und männlichen Genitaltrakts sowie der Mamma

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