Primary Malignant Melanoma Arising in an Ovarian Mature Cystic Teratoma - A Case Report and Literature Review -

Lee, Sang-Ho; Kim, Ji Hoon; Chon, Gyu Rak; Kim, Aeree; Kim, Baek Hui

doi:10.4132/koreanjpathol.2011.45.6.659

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…4 Although the current authors agree that one cannot rule out a rare possibility of a regressed cutaneous primary melanoma presenting with ovarian metastasis, the positive peritoneal biopsy and fluid cytology in the presence of ovarian melanoma strongly points to ovarian origin. 4,16 It has also been suggested that, if an ovarian cystic teratoma is associated with markedly elevated levels of CA-19-9, lactate dehydrogenase (LDH), and squamous-cell carcinomarelated antigen, there is a strong possibility of a malignant melanoma arising in a teratoma. 17 In the current case the patient had elevated levels of LDH and other markers were not measured.…”

Section: Discussionmentioning

confidence: 99%

Metastasizing Primary Malignant Melanoma of the Ovary: A Diagnostic Enigma

Hulikal

BanothManilal

GangasaniRevanth

et al. 2015

Journal of Gynecologic Surgery

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Background: Primary melanoma of the ovary is very rare; fewer than 50 cases have been reported to date. The diagnosis is challenging and is usually one of exclusion of the more-common metastatic diseases. This article describes such a case in detail and reviews relevant literature. Case: A 58-year-old perimenopausal woman presented with a 2-month history of pain and distension of the abdomen. On evaluation, she was found to have bilateral ovarian complex cysts with ascites. In view of her elevated CA 125 level and positive ascitic fluid cytology, she underwent a staging laparotomy. The final histopathology was reported as a malignant melanoma of the left ovary within a cystic teratoma with metastatic involvement of the right ovary, peritoneum, omentum, and mesentery. Results: Following surgery, this patient was evaluated with a whole body F18 flourodeoxyglucose positron emission tomography/computed tomography scan to look for any probable site of primary or other metastatic areas that had not revealed any other sites of disease. She was referred to the medical oncology services of the Sri Venkateswara Institute of Medical Sciences, in Tirupathi, Chittoor District, AP, India, for further treatment. As of this writing, she had completed two cycles of temozolomide chemotherapy with few side-effects. Conclusions: Primary malignant melanoma of the ovary is difficult to diagnose without a component of teratoma. Even with teratomatous elements, this is a diagnosis that involves excluding more-common metastatic disease from a more-common cutaneous primary. ( J GYNECOL SURG 31:166)

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Section: Discussionmentioning

confidence: 99%

Metastasizing Primary Malignant Melanoma of the Ovary: A Diagnostic Enigma

Hulikal

BanothManilal

GangasaniRevanth

et al. 2015

Journal of Gynecologic Surgery

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“…Less frequent histologic types include adenocarcinoma, sarcomas, thyroid carcinoma, malignant melanoma, and neuroectodermal tumors, among others (Table 1). 10,13–56 Carcinomas can arise from any mature epithelial tissue. Squamous cell carcinoma in mature cystic teratoma arises from the epidermal component via a carcinoma in situ pathway, or from the respiratory epithelium via squamous metaplasia/dysplasia/carcinoma in situ pathway 2,7,11 .…”

Section: Histopathologymentioning

confidence: 99%

Malignant transformation of mature cystic teratoma of the ovary

Atwi

Kamal

Quinton

et al. 2022

J of Obstet and Gynaecol

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Mature cystic teratoma is the most common ovarian germ cell neoplasm. Malignant transformation is a rare occurrence, accounting for 1.5%–2% of cases. Malignant changes can arise from any constituent tissue of a teratoma; however, squamous cell carcinoma is the most common histologic type seen, followed by adenocarcinoma and sarcoma respectively. Tumor marker concentration levels, age, and the tumor maximum diameter are predictive indicators for malignant transformation. Proper diagnosis includes recognizing the possibility of malignant transformation versus excluding other differential options, such as metastasis. Primary cytoreductive surgery, adjuvant chemotherapy, and radiotherapy are the current treatment methods. The aim of the review is to discuss the clinical and pathologic features of malignant transformation within mature cystic teratomas, while reviewing the reported malignant types, differential diagnoses, and treatment options. Data sources include review of pertinent peer‐reviewed literature on malignant transformation of mature cystic teratoma and cases seen in authors' institutional practice. Mature cystic teratomas are a commonly encountered benign ovarian tumor. However, the possibility of malignant transformation should remain in consideration, especially with given clinical or pathologic features: increased patient age, tumor size, or tumor marker levels. Thorough sampling of solid tumor foci can help identify malignant components. Awareness and proper diagnosis, along with early detection and clinical management, shows improved patient outcomes.

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“…Symptoms are usually non-specific, arising from the presence of a tumor in the pelvis minor and general malignancy and include general weakness, loss of appetite, weight loss, abdominal distension, early satiety, lower abdominal pain, lower back pain, abdominal fullness, although the course may also be asymptomatic [31,41,42]. The first symptoms may be organ-specific and related to the metastatic focus.…”

Section: Characteristicsmentioning

confidence: 99%

“…In the case of a patient with brain metastases, the first symptoms were headache, dizziness, nausea, vomiting and photophobia [38]. In 10 of the 18 analyzed cases, patients had metastases involving the pelvic organs, bowel, appendix, omentum, brain, lung, liver and adrenal gland already at the beginning of the diagnostic process [33,35,36,[38][39][40][41][42].…”

Section: Characteristicsmentioning

confidence: 99%

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Therapeutic Management of Rare Primary Ovarian Neoplasms: Carcinosarcoma, Leiomyosarcoma, Melanoma and Carcinoid

Kozłowski

Nowak

Kordek

et al. 2021

IJERPH

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Carcinosarcoma, leiomyosarcoma, melanoma and carcinoid as primary tumors in the ovary are extremely rare. In this paper, the authors reviewed the literature from 2010 to 2021, based on specific criteria, to analyze the treatment of these rare ovarian neoplasms. We also aimed to verify whether modern therapies have been found in recent years. For this article, 80 papers were finally selected. The vast majority of the articles were clinical case reports. Despite single mentions of new potential pharmacological treatments, surgery (radical or fertility-sparing) is definitely the mainstay of treatment. There are currently no treatment guidelines for these tumors. A review of the literature has revealed the use of various adjuvant treatments. We, therefore, believe that a more detailed understanding of the biology of these tumors is necessary in order to find new target points for treatment. We would like to emphasize the importance of creating an international database of rare ovarian tumors which would make it possible to gather data from various oncological centers and enable further research into these neoplasms.

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Primary Malignant Melanoma Arising in an Ovarian Mature Cystic Teratoma - A Case Report and Literature Review -

Cited by 7 publications

References 17 publications

Metastasizing Primary Malignant Melanoma of the Ovary: A Diagnostic Enigma

Metastasizing Primary Malignant Melanoma of the Ovary: A Diagnostic Enigma

Malignant transformation of mature cystic teratoma of the ovary

Therapeutic Management of Rare Primary Ovarian Neoplasms: Carcinosarcoma, Leiomyosarcoma, Melanoma and Carcinoid

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