Primary Malignant Melanoma of Breast: A Rare Entity

Vv, Gautam; Banu, R; Muthialu, Nagarajan; Pa, Raj

doi:10.17659/01.2020.0011

Cited by 1 publication

(1 citation statement)

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“…Another important step is to differentiate metastatic melanoma to the breast from other primaries in skin. A thorough complete skin examination should be performed to exclude the presence of a primary [13]. Paget's disease of the breast (nipple and areola complex) may look like cutaneous melanoma and needs to be differentiated from it as treatment approaches are not the same.…”

Section: Approach To Diagnosismentioning

confidence: 99%

Rare Breast Cancer: Primary Melanoma of Breast Parenchyma

Mohamed Moneer Abulfotooh,

Amal Yousif Saleh,

Ashraf Ahmed Abdeltawab

et al. 2023

Int J Oncol Res

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Melanoma is a highly aggressive cancer that can be cutaneous (most common) or mucosal, affecting the skin or mucous membranes at any organ in the body. It can also be found in the eye (uveal). Breast melanoma is rare, and it can manifest in one of three forms: 1) Metastatic secondary to primary melanoma at another site, 2) Primary cutaneous melanoma arising at the breast skin, or 3) Primary noncutaneous melanoma arising in the breast parenchyma itself. The latter is exceedingly rare and till date, almost only twenty-two cases have been reported in literature, including the case in the current study. Due to the rarity of this type of melanoma, it should be diagnosed in a stepwise approach after exclusion of any potential differential diagnosis. Immunohistochemistry (IHC) is a cornerstone. Management should be simply by breast and axillary surgery according to guidelines for breast cancer, and then to be followed, if proven indicated by multidisciplinary team, by adjuvant therapy according to guidelines for melanoma. The use of radiotherapy is still under debate. Based on the rarity of this type of disease, prognosis is generally poor with overall survival less than 50%. We hereby present a case of 43-y-o lady with a final diagnosis of Primary Melanoma of Breast Parenchyma (PMBP), without skin involvement and without another-site primary, in our practice at Kuwait Cancer Control Centre (KCCC), State of Kuwait, Arabian Gulf area. Management was by surgery followed by immunotherapy. The patient approved for publishing via an informed consent.

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Section: Approach To Diagnosismentioning

confidence: 99%