Primary malignant melanoma of the vagina: A case report

Sticca, Giancarlo; Misheva, Bojana; Sebajang, Herawaty; Samouelian, Vanessa; Jamal, Rahima

doi:10.1016/j.gore.2023.101266

Gynecologic Oncology Reports

2023

DOI: 10.1016/j.gore.2023.101266

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Primary malignant melanoma of the vagina: A case report

Giancarlo Sticca,

Bojana Misheva,

Herawaty Sebajang

et al.

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2024

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Survival and Treatment Modalities in Primary Vaginal Melanoma—Case Report and a Narrative Review

Guzik,

Łukasiewicz,

Harpula

et al. 2024

JCM

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Background/Objectives: Primary vaginal melanoma (PVM) is a rare cancer representing five percent of vaginal cancers and less than one percent of all female vaginal melanomas, with an incidence rate of 0.46 per million women per year. The aim of this study was to present a case of combined therapy and conservative surgical treatment in a young patient with PVM and to perform a systematic review of the same subject. Methods: We performed a narrative review of the literature and presented a case report. Results: The review yielded a total of 43 articles. We presented treatment modalities and survival outcomes. The presented case involved a combination of surgical treatment with adjuvant therapy comprising nivolumab and ipilimumab. Conclusions: PVM is a disease with a poor prognosis; however, new treatment options are promising and have a great chance of significantly improving survival. The combination of the wide local excision of the primary lesion followed by adjuvant therapies results in the best outcomes in the treatment of PVM. Future clinical studies are warranted to provide new evidence for the treatment outcomes of nonsurgical, metastatic PVM and the adjuvant treatment of PVM.

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Survival and Treatment Modalities in Primary Vaginal Melanoma—Case Report and a Narrative Review

Guzik,

Łukasiewicz,

Harpula

et al. 2024

JCM

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show abstract

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Primary malignant melanoma of the vagina: A case report

Cited by 1 publication

References 12 publications

Survival and Treatment Modalities in Primary Vaginal Melanoma—Case Report and a Narrative Review

Survival and Treatment Modalities in Primary Vaginal Melanoma—Case Report and a Narrative Review

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