Primary malignant melanoma of the vagina: Report of four cases and review of the literature

Levitan, Z.; Gordon, Alan N.; Kaplan, Alan L.; Kaufman, Raymond H.

doi:10.1016/0090-8258(89)90609-4

Cited by 33 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the above studies did not mention whether radical resection can improve RFS. One study demonstrated that the 5-year survival rate was unrelated to the type of therapy but that radical surgery appeared to control local disease (14). In our study, the surgical approach was associated with RFS according to the multivariate analysis, which corrected for potential confounding factors.…”

Section: Discussionmentioning

confidence: 55%

Surgical Outcomes of Vaginal or Cervical Melanoma

et al. 2022

View full text Add to dashboard Cite

Objective: To evaluate the effectiveness of radical resection compared with non-radical resection for vaginal or cervical melanoma.Methods: We retrospectively analysed the clinical data of post-operative patients with primary lower genital tract melanoma hospitalised at Peking University Cancer Hospital between Jan 2014 and Dec 2020. The study endpoints were recurrence-free survival (RFS) and overall survival (OS). Kaplan–Meier method-plotted survival curves and univariate and multivariate Cox proportional hazards regression models were used to identify the factors associated with RFS and OS, and to calculate hazard ratios (HRs) and associated 95% confidence intervals (95% CIs).Results: A total of 80 patients were included. Thirty-one patients had received non-radical resection, and 49 patients had received radical resection. The median patient age was 55.5 (IQR 45.3–60.0) years. Sixty-two (77.5%) patients had vaginal melanoma. Sixty-four patients (80.0%) had received post-operative adjuvant therapy. The median follow-up time was 36.0 months (95% CI 10.1–62.1 months). Sixty-four patients developed recurrence, and 44 patients died. The median RFS (mRFS) was 6.0 months (95% CI 3.4–8.6 m), and the RFS for the radical resection group was longer than that for the non-radical resection group (9.5 vs. 5.3 m), with no significant difference (P > 0.05). The median OS (mOS) was 25.9 months (95% CI 14.4–37.4 m). The mOS was 24.6 months (95% CI 10.3–38.9 m) and 25.9 months (95% CI 10.9–40.9 m) in the non-radical resection group and the radical resection group, respectively. Multivariate Cox regression analysis showed that surgical approach, infiltration depth of the tumour, lymph node metastasis, and post-operative adjuvant therapy were independent risk factors for RFS and that post-operative adjuvant therapy was an independent risk factor for OS.Conclusion: By performing multivariate analysis, which corrected for potential confounding factors, we identified surgical procedures that were associated with RFS, and we found that RFS and OS in patients with vaginal melanoma and cervical melanoma benefitted from post-operative adjuvant therapy.

show abstract

Section: Discussionmentioning

confidence: 55%

Surgical Outcomes of Vaginal or Cervical Melanoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Die insgesamt besten lokoregionären Resultate wurden durch «wide local excision» und adjuvante pelvine Radiotherapie und Brachytherapie erreicht [4,14] . Levitan et al [26] postulierte als optimale Durchführung einer «wide local excision» einen tumorfreien Resektionsrand von 2 cm. Für Chemotherapie und Antiöstrogen-Therapie gibt es in der adjuvanten Behandlung des vaginalen Melanoms keine Indikation [27] .…”

Section: Diskussionunclassified

Primäres malignes Melanom der Vagina – Fallbericht und Literaturübersicht

Betschart

Orelli

Mihic

et al. 2007

Gynäkol Geburtshilfliche Rundsch

View full text Add to dashboard Cite

Das primäre maligne Melanom der Vagina ist ein sehr seltenes Malignom mit weltweit weniger als 300 publizierten Fällen. Noch viel seltener sind Melanommetastasen in der Vagina mit bis anhin 5 beschriebenen Fällen. Bei der von uns beschriebenen Patientin zeigte sich ein von der linken Vaginalwand ausgehendes, 6 cm im Durchmesser messendes und 2,5 cm tiefes Melanom der Vagina ohne lokoregionäre Lymphknoten- oder Fernmetastasen in der Bildgebung. In der Literatur werden als Erfolg versprechendste Therapiemodalitäten die «wide local excision» mit adjuvanter Radiotherapie und die Radikaloperation mit adjuvanter Radiotherapie diskutiert, die ähnliche 5-Jahres-Überlebensraten zeigen. Zur Reduktion des doch erheblichen Risikos der Fernmetastasierung war als weiterführende systemische Therapie eine Immunmodulation mit Interferon-α_2b vorgesehen, welche bei fortgeschrittenen Melanomen der Haut etabliert ist. Leider lag bei der Planung der Interferontherapie 6 Monate nach Diagnosestellung im PET-CT eine ausgedehnte Metastasierung vor, so dass anstelle der Interferontherapie eine palliative Chemotherapie mit Dacarbazine und Thalidomid durchgeführt wurde.

show abstract

Tumors of the Vulva and Vagina

Broach

Leitao

2017

Textbook of Uncommon Cancer

View full text Add to dashboard Cite

Primary malignant melanoma of the vagina: Report of four cases and review of the literature

Cited by 33 publications

References 34 publications

Surgical Outcomes of Vaginal or Cervical Melanoma

Surgical Outcomes of Vaginal or Cervical Melanoma

Primäres malignes Melanom der Vagina – Fallbericht und Literaturübersicht

Tumors of the Vulva and Vagina

Contact Info

Product

Resources

About