Primary malignant melanoma of the rectum. Evidence for origination from rectal mucosal melanocytes

Werdin, Christin; Limas, Catherine; Knodell, Robert G.

doi:10.1002/1097-0142(19880401)61:7<1364::aid-cncr2820610715>3.0.co;2-b

Cited by 62 publications

(20 citation statements)

References 10 publications

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“…No melanomas convincingly emerged exclusively in the rectum, which is in accordance with a previous report that the colonic mucosa does not contain melanocytes [13], but at variance with two case reports claiming that melanocytes and ARMM can be found primarily in the rectum [20,21]. However, we noted a discrepancy between the localization of these tumours to specific parts of the ano-rectal unit compared to those registered according to the ICD-7 coding.…”

Section: Discussionsupporting

confidence: 90%

Primary ano-rectal malignant melanomas within a population-based national patient series in Sweden during 40 years

et al. 2009

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Section: Discussionsupporting

confidence: 90%

Primary ano-rectal malignant melanomas within a population-based national patient series in Sweden during 40 years

et al. 2009

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“…Melanocytes have been documented to reside within the native rectal mucosal epithelium [9,10]. Primary gastrointestinal malignancies of the esophagus and anorectum have now been well documented to arise in situ; from their growth pattern it is clear that these are not metastasis from cutaneous sites.…”

Section: Introductionmentioning

confidence: 99%

Primary melanomas of the esophagus and anorectum: epidemiologic comparison with melanoma of the skin

Coté

Sobin

2009

Melanoma Research

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The objective of this study was to use recently available data to describe the epidemiology of melanomas of the esophagus and the anorectum in contrast to melanoma of the skin. The methods used include descriptive epidemiology using cases reported to the Surveillance Epidemiology and End Results registry, 1973-2003. All rates were age adjusted. We found 46 759 cutaneous melanomas, 170 anorectal melanomas and 20 esophageal melanomas, corresponding to age-adjusted rates of 70.1, 0.27, and 0.03 per million population, respectively. Median age of patients with melanoma of the skin was less than those with melanoma of the anorectum or esophagus (55 years vs. 71 years and 69 years, respectively). Rates of melanoma of the skin were 1.5-fold higher for men than for women (87.1 vs. 58.1 per 10); in contrast, rates of anorectal melanoma were 1.6-fold higher for women than for men (0.324 vs. 0.199 per 10). Rates of cutaneous melanoma for whites were 13-fold higher than for blacks (80.6 vs. 6.1 per 10, P<0.001), whereas the rates of anorectal melanoma were 1.7-fold higher among whites than blacks (0.273 vs. 0.173 per 10). Comparing the period 1973-1987 with 1988-2003, the rate of cutaneous melanoma increased 1.4-fold (56.0-80.1 per 10), whereas the rate of anorectal melanoma similarly increased 1.8-fold (0.182 to 0.329 per 10).In conclusion, anorectal melanomas, and especially, esophageal melanomas remain rare malignancies. This is the first report where temporal trends in anorectal melanoma are following the increased incidence of cutaneous melanomas, but it is unclear whether immunohistochemical diagnostic practices have influenced this trend. As gastrointestinal melanomas represent melanocytic transformation in the absence of sunlight, their epidemiology may provide etiologic clues to alternative or systemic transformative factors also operant in cutaneous melanoma.

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“…Some histopathological studies hint at the possibility that anal melanocytes can migrate above the dentate line [16]; one report has described identification of melanocytes in the rectum [17]. During embryogenesis, melanocytes are believed to migrate to the ileal portion of the small intestine via the omphaloenteric duct [10].…”

Section: Discussionmentioning

confidence: 99%

Malignant melanoma of the ileo-anal pouch anastomosis after restorative proctocolectomy for ulcerative colitis: report of a case

et al. 2013

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A 62 year-old patient with therapy-refractory pouchitis after proctocolectomy for ulcerative colitis was admitted with hematochezia and abdominal discomfort. A malignant melanoma (MM) was found after repeated biopsies of the pouch. Complete staging revealed no evidence for distant metastases and the patient underwent abdominoperineal pouch resection. Six weeks later, the patient was readmitted because of severe general deterioration and diffuse metastatic spread to the liver was found. The patient died of hepatorenal syndrome shortly thereafter.Patients with inflammatory bowel disease are at increased risk of developing cancer, including rarities such as MM. Our experience stresses the importance of repeated biopsies in therapy-refractory pouchitis.

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Primary malignant melanoma of the rectum. Evidence for origination from rectal mucosal melanocytes

Cited by 62 publications

References 10 publications

Primary ano-rectal malignant melanomas within a population-based national patient series in Sweden during 40 years

Primary ano-rectal malignant melanomas within a population-based national patient series in Sweden during 40 years

Primary melanomas of the esophagus and anorectum: epidemiologic comparison with melanoma of the skin

Malignant melanoma of the ileo-anal pouch anastomosis after restorative proctocolectomy for ulcerative colitis: report of a case

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