Primary malignant melanoma of the gallbladder, metastatic to the common bile duct

Verbanck, J.; Rutgeerts, L; Aelst, Filip J. Van; Tytgat, Joost H.; Decoster, J; Noyez, D; Theunynck, Paul; Geboes, Karel

doi:10.1016/0016-5085(86)90461-0

Cited by 32 publications

(18 citation statements)

References 14 publications

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“…There may be aggressive disease causing death within months or an indolent course with recurrence long after the disease was thought to be cured. 4,13 Primary cutaneous melanoma can metastasize to any organ 12,14 and is known for its propensity for metastasis to multiple sites. 9,15 Melanoma commonly metastasizes to the small intestine-up to 60% of patients dying with malignant melanoma will have intestinal metastases at autopsy.…”

Section: Discussionmentioning

confidence: 99%

Malignant Melanoma of the Gallbladder: A Report of Two Cases and Review of the Literature

Samplaski

Rosato

Witkiewicz

et al. 2008

Journal of Gastrointestinal Surgery

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Melanoma metastatic to the gallbladder is rare. When present, it is often part of a widespread complex of metastases. Primary gallbladder melanomas are also extremely rare and can sometimes be difficult to distinguish from metastatic lesions. The optimal treatment for malignant melanoma of the gallbladder remains unclear, and prognosis is generally poor. We present here two cases of patients with metastatic lesions to the gallbladder. One patient presented with symptomatic cholelithiasis and was found incidentally to have a metastasis. Another patient had known a metastasis, but underwent curative resection of the only site of disease. We review the published literature for gallbladder melanoma, both primary and metastatic to determine the role of surgery in this disease.

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Section: Discussionmentioning

confidence: 99%

Malignant Melanoma of the Gallbladder: A Report of Two Cases and Review of the Literature

Samplaski

Rosato

Witkiewicz

et al. 2008

Journal of Gastrointestinal Surgery

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“…It is observed that the majority of melanomas of the bile duct represent metastases from a cutaneous source and tend to present as multiple, flat pigmented lesions, whereas primary lesion manifests as a single pedunculated polypoid mass in the lumen of duct. 3 - 5 Our case was novel, because it manifested as perihilar mass with CHD narrowing, which is not reported in literature thus far.…”

Section: Discussionmentioning

confidence: 77%

Primary Bile Duct Melanoma Causing Obstructive Jaundice

Addepally

Klair

Lai

et al. 2016

ACG Case Reports Journal

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Malignant melanoma is one of the few malignancies that are well known for unusual behavior. Primary malignant melanoma usually originates from squamous epithelium of skin, mucous membranes, retina, and uvea. Although melanoma can metastasize to any part of the body, including biliary tract, primary malignant melanoma of bile ducts is an extremely rare entity. We present a 52-year-old man who presented with 5-month epigastric pain and 15-pound weight loss, with 1-week duration of jaundice, nausea/vomiting, pale stools, and dark urine, blood work suggested cholestatic jaundice. Imaging revealed a large perihilar/peripancreatic mass involving the portal vein and hepatic artery, and intrahepatic biliary dilation. Biliary brushings revealed neoplastic cells strongly suggestive of malignant melanoma.

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“…A search throughout Medline showed 18 metastatic melanomas to the common bile duct reported so far [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] . Within this period, about 20 cases of primary malignant melanomas of the common bile duct have been described.…”

Section: Discussionmentioning

confidence: 99%

“…However, in spite of confirmatory immunohistochemical stains, electron microscopic studies, the presence of junctional activity adjacent to the tumour, and tests to rule out other possible remote or concurrent primary sites, absolute exclusion of a metastatic melanoma from an unknown occult site or regressed site is not entirely possible [20] . The melanoma secondaries usually arise from the primary skin lesion but occasionally they may arise from primary or metastatic melanoma of the gallbladder [7,12,16] . Patients with metastatic melanoma to the common bile duct usually present with progressive painless obstructive jaundice [4,19] .…”

Section: Discussionmentioning

confidence: 99%

Metastatic melanoma to the common bile duct causing obstructive jaundice: A case report

Colović¹,

Grubor²,

Jovanovic³

et al. 2007

WJG

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Primary malignant melanoma of the gallbladder, metastatic to the common bile duct

Cited by 32 publications

References 14 publications

Malignant Melanoma of the Gallbladder: A Report of Two Cases and Review of the Literature

Malignant Melanoma of the Gallbladder: A Report of Two Cases and Review of the Literature

Primary Bile Duct Melanoma Causing Obstructive Jaundice

Metastatic melanoma to the common bile duct causing obstructive jaundice: A case report

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