Primary Malignant Melanoma of the Esophagus With Unusual Endoscopic Findings

Liu, Hui; Yan, Yan; Jiang, Chunmeng

doi:10.1097/md.0000000000003479

Cited by 10 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The typical endoscope visualization shows a polypoid lesion, accompanied rarely by ulcers. PMME is usually pigmented, and the endoscopically viewed characteristic black mass supports the diagnosis of PMME[10]. Because of the paramagnetic property of melanin, magnetic resonance images reveal pigmented melanomas by their distinctive 'short T 1 and short T 2 signals'[11].…”

Section: Discussionmentioning

confidence: 99%

Advanced primary amelanotic malignant melanoma of the esophagus: A case report

Zhang

Liu

et al. 2019

WJCC

View full text Add to dashboard Cite

BACKGROUNDPrimary malignant melanoma of the esophagus accounts for 0.1%-0.2% of all esophageal malignancies, including melanotic and amelanotic melanomas. Primary amelanotic malignant melanoma of the esophagus is extremely rare, and only about 20 cases have been published in the literature to date. Most primary malignant melanomas of the esophagus are diagnosed following development of metastatic lesions and thus have a very poor prognosis. The median survival duration of patients with metastatic melanoma has been reported to be 6.2 mo.CASE SUMMARYA 49-year-old woman was referred to our hospital with a diagnosis of esophageal cancer. Endoscopy, biopsy, imaging evaluation, and physical examination at our hospital indicated a diagnosis of advanced primary amelanotic malignant melanoma of the esophagus. Immunohistochemical staining confirmed melanoma. Nuclear medicine examination revealed a left iliac bone metastatic lesion. After discharge, the patient self-administered apatinib for 3 mo, followed by oral treatment with Chinese medicines (also self-administered) for 2 mo. No treatments had been taken since then. The patient has survived with no growth out to the most recent follow-up (24 mo post diagnosis), and she always presented with a positive attitude about her condition during this period.CONCLUSIONSurvival following metastatic melanoma might be related to the pharmaceutical and Chinese medicine treatment and the patient's positive attitude.

show abstract

Section: Discussionmentioning

confidence: 99%

Advanced primary amelanotic malignant melanoma of the esophagus: A case report

Zhang

Liu

et al. 2019

WJCC

View full text Add to dashboard Cite

show abstract

“…The most common symptoms is progressive dysphagia [ 5 ] as well as, in our case, other symptoms include antiacid, heartburn, retrosternal pain, hematemesis, black stool, and weight loss, whereas a few patients are asymptomatic at diagnosis. [ 3 , 12 – 14 ] The shape of the tumor can be polypoid, nodular, beaded, or cauliflower-like. In 85% of cases, the lesions had pale, brown, blue, black, or dark-brown pigmentation.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 , 2 ] The average age of the patients with PMME is 60.5 years and the ratio of men to women is 2:1. [ 3 ] Along with the high aggressiveness of the disease, the median survival time of PMME is 13.4 months and 5-year overall survival rate is around 4%, [ 4 , 5 ] the rate may be improved to 37.5% after surgical resection according to a recent study. [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

Malignant melanoma of the esophagus complicated with poorly differentiated mucinous adenocarcinoma of the stomach

Li¹,

Liu²,

Wang³

et al. 2019

Medicine

View full text Add to dashboard Cite

Rationale:Primary malignant melanoma of the esophagus (PMME) is a rare malignancy that only accounts for <2% of all primary esophageal tumors. Here, we report the even rarer occurrence of PMME in combination with poorly differentiated mucinous adenocarcinoma of the stomach.Patient concerns:A 64-year-old man was presented to the hospital with >1 month of eating dysphagia. Enhanced computed tomography (CT) scan only found a space-occupying lesion in the lower esophagus with moderate enhancement. However, gastroscope showed not only esophageal masses, but also gastric mucosa changes.Diagnoses:Poorly differentiated mucinous adenocarcinoma and PMME were diagnosed based on pathological biopsy and immunohistochemical methods.Interventions:The patient underwent laparoscopic gastric cancer radical surgery, esophageal resection, and colonic replacement of the esophagus.Outcomes:Abdominal CT and esophagography performed 1 week after surgery showed that it was consistent with postoperative changes without other abnormalities. However, the patient died 3 months after discharge without receiving any other treatment.Lessons:This case suggests more attention should be drawn to the diagnosis of multiple primary malignant neoplasms in elder patients, and also highlights the need to fulfill comprehensive examinations before surgery in case of misdiagnosis. Besides, it is challenging to finding a reasonable treatment for such rare condition.

show abstract

“…It also has various colors depending on the melanin quantity . One case report described an unusual endoscopic finding for PMME with presentation of a mass that extended for 15 cm along the esophageal longitudinal axis and invaded half of the esophageal circumference …”

Section: Discussionmentioning

confidence: 99%

Endoscopic findings in a patient with primary malignant melanoma of the esophagus: A case report

Chu

Peng

Chang

et al. 2019

Adv in Digestive Medicine

View full text Add to dashboard Cite

Primary malignant melanoma of the esophagus (PMME) is a rare tumor with poor prognosis, rapid progression, and early metastasis. It often occurs in the middle to lower part of the esophagus. Endoscopic findings reveal various colors ranging from white, brown, and purple to black, and the lesions could be ulcerative, superficial, or protruding polypoid. Only a few reports about endoscopic findings of PMME are available in the literature. Here, we describe a case of a 77‐year‐old man who suffered from epigastric pain and acid regurgitation for 2 weeks. Endoscopic findings revealed an ulcerative lesion with purple‐black pigmentation in the lower part of the esophagus. Endoscopic biopsy was performed. Hematoxylin and eosin (H&E) staining showed a subepithelial nodule with melanocytosis and a high nuclear‐cytoplasmic (N/C) ratio and macronucleoli. Immunohistochemical staining revealed positive results for S‐100, HMB‐45, and melan‐A. Based on these pathologic and immunohistochemical examinations, the patient was diagnosed with PMME. However, the patient initially hesitated to undergo surgical intervention until he developed dysphagia 2 years later. We also present a series of endoscopic images of PMME of this patient in this paper.

show abstract

Primary Malignant Melanoma of the Esophagus With Unusual Endoscopic Findings

Cited by 10 publications

References 18 publications

Advanced primary amelanotic malignant melanoma of the esophagus: A case report

Advanced primary amelanotic malignant melanoma of the esophagus: A case report

Malignant melanoma of the esophagus complicated with poorly differentiated mucinous adenocarcinoma of the stomach

Endoscopic findings in a patient with primary malignant melanoma of the esophagus: A case report

Contact Info

Product

Resources

About