Primary malignant melanoma of the urethra

Katz, Erin E.; Suzue, Kimiko; Wille, Mark; Krausz, Thomas; Rapp, David E.; Sokoloff, Mitchell H.

doi:10.1016/j.urology.2004.09.002

Cited by 25 publications

(17 citation statements)

References 9 publications

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“…[2] Primary malignant melanomas consist nearly 4% of urothelial tumors. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Malignant melanomas are most often localized within distal urethra. In men it is most frequently found in fossa navicularis (55%), urethral meatus (5%), pendulous (15%), bulbous (10%), and prostatic urethra (15%).…”

Section: Discussionmentioning

confidence: 99%

“…Since malignant melanoma of the urethra metastatize at an early stage of the disease, early diagnosis is essntial, and an extensive surgical excision before development of metastases seems to be the only treatment alternative. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Rikaniadis et al [17] recommended local excision as a conservative treatment modality which maintains quality of life of the patient in selected cases of malignant melanoma localized in distal urethra. [18] Lee et al [19] noted disease-free survival during a 12 months of the follow-up period in a 74-year-old patient diagnosed as primary malignant melanoma of the urethra without lymph node involvement who had undergone partial penectomy, and lymph node dissection.…”

Section: Discussionmentioning

confidence: 99%

“…Urethral melanomas rarely manifest clinical symptoms, and its delayed detection retards effective treatment. [1] Definitive diagnosis is made based on histopathological findings. In our case, the patient underwent biopsy with the initial diagnosis of urethral caruncle, and histopathology was reported as malignant melanoma.…”

Section: Introductionmentioning

confidence: 99%

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Primary melanoma of the male urethra

Karaman

Yeşil

2014

Turkish Journal of Urology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary melanoma of the male urethra

Karaman

Yeşil

2014

Turkish Journal of Urology

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“…The rarity of these lesions can lead to their misdiagnosis (68,69). Their very poor prognosis is due to their tendency to locally invade the corpus cavernosus in men and both the vulva and vagina in women.…”

Section: Melanomas Of the Urethramentioning

confidence: 99%

Extracutaneous Malignant Melanomas

Hussein

2008

Cancer Investigation

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Extracutaneous malignant melanomas are rare tumors with vexing clinical presentation and grim prognosis. Only 4%-5% of all primary melanomas do not arise from the skin. These tumors are almost uniformly fatal, even in 2006. Although a fairly good number of these lesions were reported in the literature, the lack of a side-by-side analysis of these studies has resulted in tentative conclusions that merely offer a first glimpse at the clinicopathologic diversity of these lesions. To remedy this issue, this article took an aim at presenting a literature review concerning extracutaneous malignant melanomas. It also reports several cases of extracutaneous melanomas, which I came across in my 15 years of surgical and molecular pathology practice. The study raises several notions. Extracutaneous malignant melanomas are rare but extremely aggressive lesions with a grim outcome. They include ocular, metastatic, anorectal, mucosal, nail beds, conjunctival, vaginal, urogenital, orbital, esophageal, and leptomeningial malignant melanomas. The development of these lesions lacks an association with sun damage, family history, or precursor nevi. These lesions cause considerable diagnostic consternation and their distinction from other types of tumors (such as undifferentiated carcinomas, high-grade sarcomas, and lymphomas) is critical both from a diagnostic and prognostic point of view. In the proper clinical, histological, and cytological context, immunopositivity for S100 protein, HMB45, and vimentin allows the distinction of these malignant melanomas from other histologically similar malignancies. To conclude, extracutaneous melanoma should be considered while undifferentiated neoplasms, especially those displaying prominent eosinophilic nucleoli, and the coexistence of epithelioid and spindle cells. Special staining and immunohistochemistry should be resorted to establish the diagnosis.

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“…Since the clinical presentation of urethral melanoma is similar to that of urothelial carcinoma, there is frequently a delay in diagnosis [4]. According to the literature, most cases of malignant melanoma in the female urethra involve the meatus and/or distal urethra [5].…”

Section: Introductionmentioning

confidence: 99%

Primary malignant melanoma of the female urethra: a rare case of cytological observation

Kawaguchi¹,

Nambu²,

Sekiya³

et al. 2014

Pathol Discov

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We herein report a rare case of primary malignant urethral melanoma developed in an elderly Japanese patient with hypertension, diabetes and hyperlipidemia. An 80-year-old female presented at our hospital with a history of urodynia and perineal pain lasting for several months. Cystoscopy revealed cystitis and urethritis with erosion. At that time, urinary cytology was negative for malignancy, although melanophages were observed. Four months later, lower abdominal computed tomography and magnetic resonance imaging indicated urethral tumors. Urinary cytology subsequently detected malignant melanoma, and a biopsy of the urethra confirmed malignancy. Although inguinal lymph node metastasis was found 16 months postoperatively, the patient has remained free of disease for more than six years after surgery and chemotherapy.

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Primary malignant melanoma of the urethra

Cited by 25 publications

References 9 publications

Primary melanoma of the male urethra

Primary melanoma of the male urethra

Extracutaneous Malignant Melanomas

Primary malignant melanoma of the female urethra: a rare case of cytological observation

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