Primary Malignant Melanoma of the Esophagus: Report of a Case Successfully Treated with Pre- and Post-operative Adjuvant Hormone-Chemotherapy

Naomoto, Yoshio; Perdomo, José A. Polanía; Kamikawa, Yasuaki; Haisa, Minoru; Yamatsuji, Tomoki; Arakawa, Kiyoshi; Taguchi, Kohji; Hara, Kyoko; Tanaka, Noriaki

doi:10.1093/jjco/28.12.758

Cited by 42 publications

(51 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, even in those patients who were successfully administered these treatments, the majority also underwent surgery (19)(20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the esophagus: A case report and review of the literature

2015

View full text Add to dashboard Cite

Abstract. Primary malignant melanoma of the esophagus (PMME) is a rare malignancy and the prognosis is typically poor. There is currently a lack of appropriate treatment strategies and clear guidance. The current study presents the case of a 65-year-old female with a two-month history of progressive dysphagia, the investigations of which resulted in a diagnosis of PMME. The patient was treated with a radical transhiatal esophagectomy with subcarinal lymphadenectomy followed by combined chemoimmunotherapy. The patient remains alive with no evidence of tumor progression at the 12-month follow-up. The purpose of the present study was to report a new case and to review the recent relevant literature regarding the treatment of PMME.

show abstract

“…Nevertheless, even in those patients who were successfully administered these treatments, the majority also underwent surgery (19)(20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the esophagus: A case report and review of the literature

2015

View full text Add to dashboard Cite

show abstract

“…Total or subtotal esophagectomy is recommended by most authors as this tumor tends to spread longitudinally [45-47, 49, 50]. Radical lymphadenectomy has been performed in some cases [49,51] but is not generally recommended. There is no clear evidence that radiotherapy can be effective as a primary treatment but is essentially employed as a palliative or adjuvant measure [47,51].…”

Section: Melanoma Of the Esophagusmentioning

confidence: 99%

“…Radical lymphadenectomy has been performed in some cases [49,51] but is not generally recommended. There is no clear evidence that radiotherapy can be effective as a primary treatment but is essentially employed as a palliative or adjuvant measure [47,51]. Recently, radiation with heavy ion beams has been reported to show promising results as it permits selective irradiation with minimal injury to the surrounding normal tissue [52].…”

Section: Melanoma Of the Esophagusmentioning

confidence: 99%

Primary Extracutaneous Malignant Melanoma: A Comprehensive Review with Emphasis on Treatment

et al. 2004

View full text Add to dashboard Cite

Extracutaneous malignant melanomas (EMM) require special consideration in the field of oncology due to their rareness and – depending on the localization – the frequency of late diagnosis with consecutive poor prognosis. Only 4–5% of all primary melanomas do not arise from the skin. Most frequently they originate from the mucous membranes lining the respiratory, digestive, and genitourinary tracts or in the eyes as well as in the cerebral meninges. Extracutaneous melanomas are considered to be biologically more aggressive than cutaneous melanomas. The Clark level and Breslow index used for evaluation of cutaneous melanomas are not applicable to EMM and, at present, there are no consistent, internationally accepted therapy standards for this form of the disease. For this reason, this review focuses primarily on the literature pertaining to therapeutic strategies as well as epidemiologic, biological, and diagnostic aspects of this disease.

show abstract

“…A case was recently reported of a patient treated with heavy ion radiation who achieved a complete response. However, lung and liver metastases were identified at month 5 of follow-up, requiring chemotherapy (11).…”

Section: Discussionmentioning

confidence: 99%

Primary esophageal melanoma: Report of a case

et al. 2016

View full text Add to dashboard Cite

Introduction: Primary malignant melanoma of the esophagus is a rare tumor representing only 0.1-0.2% of esophageal malignancies. The goal of the study was to report on the management of a new case diagnosed and treated in our site.Case report: A 67-year-old patient presented with dysphagia to solids with no other remarkable history or associated skin lesions. He underwent gastroscopy, which revealed a polypoid mass suggestive of neoplasm in the distal third of the esophagus. Biopsy indicated melanoma with positive immunohistochemical markers S100 and HMB45, and negative cytokeratins and CEA. Computerized tomography (CT) and positron-emission tomography (PET) scans showed no local infiltration or distant metastases. An Ivor-Lewis esophagectomy procedure was performed with regional lymphadenectomy. Postoperative stay lasted for three weeks, and no remarkable postsurgical complications arose. The pathological study of the specimen confirmed the diagnosis of primary esophageal melanoma.Discussion: Primary malignant melanoma of the esophagus has an unfortunate prognosis as it is an aggressive tumor usually diagnosed at an advanced stage, with local invasion and metastatic disease. Currently, surgery is the treatment of choice, with the remaining adjuvant therapies obtaining limited results.Key words: Primary melanoma of esophagus. Metastasis. Treatment. CASE REPORTA 67-year-old patient presents with clinical dysphagia, predominantly to solids, for the past two months, with no associated vomiting or constitutional syndrome. His history is remarkable for psoriasis, smoking, and alcohol abuse. No adenopathies could be palpated in accessible regions, his abdomen was soft, non-tender, and depressible, and no masses or organomegalies could be identified. No malignancy-suggestive skin lesions were seen.As a part of the study a gastroscopy was performed, which revealed a pigmented, villous, ulcerated, pediculated polypoid lesion in the distal esophagus, which was friable to the touch and did not block the esophageal lumen. Biopsy samples were taken, which were consistent with squamous-cell melanoma positive for immunohistochemical markers S100 and HMB45, and negative for carcinoembryonic antigen (CEA) and cytokeratins.The extension study was completed with a chest-abdominal CT scan, which revealed an endoluminal esophageal growth compatible with neoplasm at the distal third of the esophagus, in the absence of either local infiltration or distant metastases evidence (Fig. 1).A TEP scan was ordered, which showed hypermetabolism at the distal third of the esophagus and no metastatic uptake suggestive of tumor infiltration. A diagnosis of primary esophageal melanoma was then reached by exclusion.Received: 01-07-2016 Accepted: 21-07-2016Correspondence: Laura Granel-Villach. Department of General and Digestive Surgery. Hospital General de Castellón. Avda. Benicássim, s/n. 12004 Castellón, Spain e-mail: laura_9487@yahoo.es. Granel-Villach L, Moya-Sanz MA, Escrig-Sos VJ, Fortea-Sanchís C, Martínez-Lahuerta C, Tornador-Gaya N...

show abstract

Primary Malignant Melanoma of the Esophagus: Report of a Case Successfully Treated with Pre- and Post-operative Adjuvant Hormone-Chemotherapy

Cited by 42 publications

References 21 publications

Primary malignant melanoma of the esophagus: A case report and review of the literature

Primary malignant melanoma of the esophagus: A case report and review of the literature

Primary Extracutaneous Malignant Melanoma: A Comprehensive Review with Emphasis on Treatment

Primary esophageal melanoma: Report of a case

Contact Info

Product

Resources

About