Primary Malignant Melanoma of the Vagina: Long-Term Remission Following Radiation Therapy

Petru, Edgar; Nagele, Fritz; Czerwenka, K.; Graf, Anton; Lax, Sigurd; Bauer, Madeline; Pehamberger, Hubert; Vavra, N.

doi:10.1006/gyno.1998.4982

Cited by 76 publications

(40 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Specifically, the 3-year relative survival rate for patients with Clark levels of invasion II, II, IV, and V were 45%, 36%, 27%, and 14%, respectively. Besides these two large registry studies, smaller cohort studies and case series describing between 11 (22) and 44 (28) patients with PMV were identified (8,24,27,30,35,38,44,50,61,68,72,76). As expected, the heterogeneity among these studies with low numbers of patients with PMV was considerable.…”

Section: Literature Reviewmentioning

confidence: 67%

Melanoma of the Vagina: Case Report and Systematic Review of the Literature

Rapi

Doğan

Schultheis

et al. 2017

View full text Add to dashboard Cite

Abstract. Background: Primary melanoma of the vagina (PMV) is a rare entity. The prognosis of women with PMV is poor and there is no standardized therapy for this type of malignancy. We present the case of a 72-year-old womanwith PMV (cT2, pN0, M0 Melanoma is caused by the malignant transformation of pigment cells. Apart from the skin, pigment cells such as melanocytes are present in various mucosal linings such as those of the gastrointestinal, respiratory, and urogenital tracts (1). Thus, in addition to the common cutaneous locations, melanomas may also arise in mucosal areas of various organs. Cutaneous melanomas are estimated to be the sixth most common cancer entity among females in the US (2). In contrast, mucosal melanomas are rare and account for only 1.4% of all melanomas. Of note, gender plays an important role in the epidemiology of mucosal melanomas. With almost three cases per million women, which is half that for men, mucosal melanomas are significantly more often diagnosed among women (3). This gender gap is caused by the fact that genital tract mucosal melanomas are more common among women than they are among men, whereas extra-genital mucosal melanomas are evenly distributed between the sexes (3).In the female genital tract, the predominant location of melanoma is the vulva whereas the vagina is rarely affected (3). Specifically, the incidence of primary melanoma of the vagina (PMV) is about three cases per 10,000,000 women per year. Primary melanomas of the vulva are four to nine times more frequent than PMV (4, 5). PMV is typically diagnosed in elderly women at an advanced stage and is characterized by early recurrence and a poor prognosis (2). The 5-year overall survival rate for PMV is below 20% compared to around 45% for those with vulvar melanoma and >80% for those with cutaneous melanoma (2-6). This remarkable difference has been attributed to a variety of 6911 This Αrticle is freely accessible online.

show abstract

Section: Literature Reviewmentioning

confidence: 67%

Melanoma of the Vagina: Case Report and Systematic Review of the Literature

Rapi

Doğan

Schultheis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Another series with 14 patients confirmed the correlation between tumour size and prognosis. Thus, 3 of 7 patients with a tumour < 3 cm survived more than 5 years while none of the patients with a tumour > 3 cm survived longer than 5 years [10]. The median survival rate after diagnosis is approximately 20 months [7].…”

mentioning

confidence: 95%

“…The most common symptom of vaginal melanoma is vaginal bleeding, followed by dyspareunia [11,14]. The 5-year survival rate for this very aggressive, rapidly growing tumour is very poor, and is reported to be 0-25 % irrespective of the chosen therapy [10,16]. Vaginal melanomas are usually only detected in advanced stages.…”

mentioning

confidence: 99%

Primary Malignant Vaginal Melanoma - Case Report and Review of the Literature

Kühn

Dieterich

Klar

et al. 2012

Geburtsh Frauenheilk

View full text Add to dashboard Cite

With fewer than 250 cases published worldwide, primary vaginal melanoma is an extremely rare malignant entity which is mostly diagnosed in advanced stages. The estimated incidence of vaginal melanoma is 0.026/100?000 women per year. The poor prognosis for advanced tumour stages and different therapies used in very limited numbers of patients require precise preoperative staging and a planned interdisciplinary therapeutic approach.

show abstract

“…The 5-year survival rate for this very aggressive, rapidly growing tumour is very poor, and is reported to be 0 -25% irrespective of the chosen therapy [8,9]. Vaginal melanomas are usually only detected in advanced stages.…”

Section: Discussionmentioning

confidence: 99%

Primary Melanoma of the Vagina Treated by Imatinib: Case Report

Oualla¹,

Elmrabet²,

Elfatemi³

et al. 2013

JCT

View full text Add to dashboard Cite

Melanoma of the vagina is a rare lesion. It results from the malignant transformation of ectopic melanocytes occurring in post-menopause. The CKIT is expressed in 36% of cases in addition to melanoma markers. Prognosis is poor especially for inoperable and disseminated forms despite systemic therapy. Treatment with Imatinib is an option in cases of metastatic mucosal melanoma with CKIT mutation or amplification. We report the case of post-menopausal women, treated at Hassan II University Hospital, diagnosed with metastatic melanoma of the vagina, that didn't respond to first line of chemotherapy, and received Imatinib as second line of treatment, with good clinical response and durable stability at radiological assessment.

show abstract

Primary Malignant Melanoma of the Vagina: Long-Term Remission Following Radiation Therapy

Cited by 76 publications

References 16 publications

Melanoma of the Vagina: Case Report and Systematic Review of the Literature

Melanoma of the Vagina: Case Report and Systematic Review of the Literature

Primary Malignant Vaginal Melanoma - Case Report and Review of the Literature

Primary Melanoma of the Vagina Treated by Imatinib: Case Report

Contact Info

Product

Resources

About