Primary malignant melanoma of the oesophagus: two case reports

Pun, Amy Hoi-Ying; Devitt, Peter G.

doi:10.1093/jscr/rju005

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…From 2013 to 2016, other 35 cases of PMME were reported in literature [ 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 , 238 , 239 , 240 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 ] with a particular emphasis about the case presented by Zhang et al [ 228 ] that measured 12 cm (huge PMME).…”

Section: Discussionmentioning

confidence: 99%

The Thousand Faces of Malignant Melanoma: A Systematic Review of the Primary Malignant Melanoma of the Esophagus

Cazzato

Cascardi

Colagrande

et al. 2022

Cancers

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Primary Malignant Melanoma of the Esophagus (PMME) is an extremely rare cancer of the esophagus, accounting for 0.1–0.8% of all oro-esophageal cancers and <0.05% of all melanoma subtypes, with an estimated incidence of 0.0036 cases per million/year. We conduct a careful analysis of the literature starting from 1906 to the beginning of 2022, searching the PubMed, Science.gov, Scopus and Web of Science (WoS) databases. A total of 457 records were initially identified in the literature search, of which 17 were duplicates. After screening for eligibility and inclusion criteria, 303 publications were ultimately included, related to 347 patients with PMME. PMME represents a very rare entity whose very existence has been the subject of debate for a long time. Over time, an increasing number of cases have been reported in the literature, leading to an increase in knowledge and laying the foundations for a discussion on the treatment of this pathology, which still remains largely represented by surgery. In recent times, the possibility of discovering greater mutations in gene hotspots has made it possible to develop new therapeutic strategies of which nivolumab is an example. Future studies with large case series, with clinicopathological and molecular data, will be necessary to improve the outcome of patients with PMME.

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Section: Discussionmentioning

confidence: 99%

The Thousand Faces of Malignant Melanoma: A Systematic Review of the Primary Malignant Melanoma of the Esophagus

Cazzato

Cascardi

Colagrande

et al. 2022

Cancers

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“…As a noncutaneous melanoma, PMME has been occasionally reported since 1906. [ 2 ] To date, about 337 cases of esophageal melanoma have been published, [ 4 , 8 ] whereas copresentation with gastric cancer has not been reported.…”

Section: Discussionmentioning

confidence: 99%

“…It has been indicated that the esophageal melanocytosis is a precancerous lesion of PMME, [ 9 , 10 ] and esophageal melanocytic dysplasia will eventually develop into PMME. [ 8 , 11 ]…”

Section: Discussionmentioning

confidence: 99%

Malignant melanoma of the esophagus complicated with poorly differentiated mucinous adenocarcinoma of the stomach

Li¹,

Liu²,

Wang³

et al. 2019

Medicine

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Rationale:Primary malignant melanoma of the esophagus (PMME) is a rare malignancy that only accounts for <2% of all primary esophageal tumors. Here, we report the even rarer occurrence of PMME in combination with poorly differentiated mucinous adenocarcinoma of the stomach.Patient concerns:A 64-year-old man was presented to the hospital with >1 month of eating dysphagia. Enhanced computed tomography (CT) scan only found a space-occupying lesion in the lower esophagus with moderate enhancement. However, gastroscope showed not only esophageal masses, but also gastric mucosa changes.Diagnoses:Poorly differentiated mucinous adenocarcinoma and PMME were diagnosed based on pathological biopsy and immunohistochemical methods.Interventions:The patient underwent laparoscopic gastric cancer radical surgery, esophageal resection, and colonic replacement of the esophagus.Outcomes:Abdominal CT and esophagography performed 1 week after surgery showed that it was consistent with postoperative changes without other abnormalities. However, the patient died 3 months after discharge without receiving any other treatment.Lessons:This case suggests more attention should be drawn to the diagnosis of multiple primary malignant neoplasms in elder patients, and also highlights the need to fulfill comprehensive examinations before surgery in case of misdiagnosis. Besides, it is challenging to finding a reasonable treatment for such rare condition.

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Primary Malignant Melanoma of the Esophagus, Treated with Immunotherapy: A Case Report

et al. 2018

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Primary malignant melanoma of the esophagus is rare, accounting for less than 0.1-0.2% of all esophageal malignancies. It is associated with a poor outcome due to late detection and high metastatic potential. Here, we report a case of esophageal cancer, which was initially diagnosed as an adenocarcinoma and finally was confirmed as a primary malignant melanoma. This 75-year-old Caucasian male had a history of dysphagia and recent lingering abdominal pain. First biopsy showed a poorly-differentiated adenocarcinoma. He was then treated with neoadjuvant radiochemotherapy. Biopsies were repeated because of an incomplete tumor response, evaluated by endoscopic and imaging studies. The final diagnosis was a malignant melanoma. The patient has been treated with immune-checkpoint inhibitor, nivolumab, an anti-PD1 antibody.

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Primary malignant melanoma of the oesophagus: two case reports

Cited by 4 publications

References 5 publications

The Thousand Faces of Malignant Melanoma: A Systematic Review of the Primary Malignant Melanoma of the Esophagus

The Thousand Faces of Malignant Melanoma: A Systematic Review of the Primary Malignant Melanoma of the Esophagus

Malignant melanoma of the esophagus complicated with poorly differentiated mucinous adenocarcinoma of the stomach

Primary Malignant Melanoma of the Esophagus, Treated with Immunotherapy: A Case Report

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