Primary malignant melanoma of the cervix: 14 cases and literature overview

Sun, Haiyan; Chen, Yanfang; Chen, Ying; Li, Dongying; Yan, Zhuchen; Meng, Bin; Zhao, Gang; Pan, Zhanyu; Li, Qiang

doi:10.1097/cmr.0000000000000469

Cited by 11 publications

(6 citation statements)

References 40 publications

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“…In the exclusion phase, seven studies (five retrospective cohorts and two prospective cohorts) that included 51 cases with primary MM of the cervix were excluded from the review because they did not provide individual patient data ( Table S1 ). Finally, 96 studies [ 4 , 7 , 10 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , …”

Section: Resultsmentioning

confidence: 99%

“…Despite the aforementioned differences between MM and cervical epithelial malignancies, the management of cervical MM is mainly based on surgical approaches established for other histological types of cervical cancer [ 114 ]. Radical hysterectomy, salpingo-oophorectomy and pelvic lymphadenectomy are the cornerstones of therapeutic management with para-aortic lymphadenectomy being optional [ 24 ]. A recent integrated analysis of 149 cases confirmed the positive effect of hysterectomy-based treatments on survival [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

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Primary Melanoma of the Cervix Uteri: A Systematic Review and Meta-Analysis of the Reported Cases

Kechagias

Zafeiri

Triantafyllidis

et al. 2023

Biology

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Primary malignant melanoma (MM) of the cervix uteri is a rare and aggressive malignancy of the female reproductive tract. Considering that clinical data on this cancer are scarce, we aimed to comprehensively examine the currently available literature and provide an overview of the reported cases of cervical MM focusing on the clinical characteristics, diagnosis and therapeutic management. We conducted a systematic review of the literature by screening three electronic databases until June 2022. The critical appraisal checklist provided by the Joanna Briggs Institute was employed to evaluate the overall quality of the studies. We included 96 reports, which comprised 137 patients diagnosed with MM of the cervix. The mean age of the patients was 56.5 (median: 58, age range: 33–88). Data regarding menopausal status were provided for 98 patients with 15 being premenopausal and 83 being postmenopausal. The most common presenting symptom was vaginal bleeding (83%, 100/121). Biopsy (either excisional or punch biopsy) was used as the first diagnostic modality in most of the patients (67%, 64/95), followed by cytology (18%, 17/95). In 74 cases, the FIGO staging system for cervical cancer was used with the most common stage being FIGO stage I (38%, 28/74), followed by FIGO stage II (36%, 27/74), FIGO stage III (19%, 14/74) and FIGO stage IV (7%, 5/74). Most of the patients were managed surgically (90%, 119/131) with a hysterectomy (either radical or total), and a salpingo-oophorectomy with/without lymphadenectomy was the most common approach utilized (40%, 48/119). The data of clinical outcomes were provided for 105 patients, of whom 61 died (58%, 61/105) and 44 survived (42%, 44/105). Knowledge regarding the rare occurrence of MM in the cervix and the increased awareness of clinicians can prevent clinical misdiagnosis and ultimately improve further the clinical outcomes of patients developing this rare malignancy.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary Melanoma of the Cervix Uteri: A Systematic Review and Meta-Analysis of the Reported Cases

Kechagias

Zafeiri

Triantafyllidis

et al. 2023

Biology

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“…Squamous cell carcinoma is the most common primary tumor in the cervix. Other rare primary tumors include clear-cell carcinoma and small-cell carcinoma, [1][2][3] primary lymphoma, 4 cervical choriocarcinoma, 5 sarcoma of the uterine cervix, 6 malignant melanoma, 7 Wilm's tumor, 8 and malignant peripheral neurilemmoma of cervical fibroblasts. 9 Cervical cancer primarily presents with hemorrhage in the early disease stage.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic diagnosis in rare primary cervical cancer

Zheng

et al. 2021

Int J Gynecol Cancer

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IntroductionAlthough ultrasonography has been reported to have similar diagnostic accuracy to magnetic resonance imaging, it is not a standard imaging modality for cervical cancer. We aimed to summarize the ultrasonographic features of rare primary cervical cancer.MethodsThis was a retrospective study of patients with cervical cancer who were diagnosed between June 2014 and October 2019. They were divided into common-type cervical cancer (ie, cervical squamous cell carcinoma) and rare-type cervical cancer groups including adenocarcinoma, adenosquamous carcinoma, and small cell carcinoma. All patients were staged according to the tumor, nodes, and metastases criteria.ResultsOf the 64 patients, the diagnosis was suspected on ultrasonography in 61 (95.3%) patients and missed on ultrasonography in three patients. The tumor size was smaller in the rare-type cervical cancer group (p<0.05). Hypoechoic lesions in common-type cervical cancer and isoechoic lesions accounted for 74.4% (32/43) and 61.9% (13/21) of patients in the rare-type cervical cancer group, respectively (p<0.001). Meanwhile, 67.4% (29/43) of tumors in common-type cervical cancer were exophytic, while 66.7% (14/21) in rare-type cervical cancer were endophytic (p=0.01). Color Doppler blood signals, as compared with normal cervical tissue, were found in all patients. There was good consistency between ultrasonographic and pathologic diagnosis of rare-type cervical cancer (weighted kappa=0.87).ConclusionsMost patients with rare-type cervical cancer present with isoechoic lesions. The coincidence rate between ultrasonographic and pathologic diagnosis of rare-type cervical cancer is 87%.

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“…Cervical squamous cell carcinoma (CSCC) is the most common primary tumor in the cervical region; other rare primary tumors include clear-cell carcinoma of the cervix (CCCC) and small-cell carcinoma of the cervix (SCCC), [1][2][3] primary lymphoma of the cervix, 4 cervical choriocarcinoma, 5 sarcoma of the uterine cervix, 6 rhabdomyoma of the cervix, 7 malignant melanoma of the cervix, 8,9 Wilm's tumor of the cervix, 10 and malignant peripheral neurilemmoma of cervical broblasts. 11 Regardless of the type of cervical neoplasm, contact hemorrhage or uor sanguinolentus are the main early clinical manifestations; late clinical manifestations include irregular vaginal bleeding of varying amounts with corresponding symptoms of distant metastasis.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic Diagnosis of Rare Primary Cervical Cancer

Zheng

et al. 2020

Preprint

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Background: To summarize ultrasonographic features of rare primary and common cervical cancer and the association of these cancers with HPV infection so as to diagnose rare primary cervical cancer.METHODS: Sixty-five cases with cervical cancer suspected by ultrasonography and three cases with clinical symptoms treated at our department underwent cervical biopsy. Sixty-four diagnosed cases were retrospectively analyzed and divided into common-type (CTCC) and rare-type (RTCC) cervical cancers.RESULTS: Sixty-one cases were diagnosed, four misdiagnosed, three missed the diagnosis by ultrasonography, the sensitivity of which was 95.31% (61/64). The common-type cervical cancer had 43 cases of squamous cell carcinoma. The rare-type cervical cancer had 15 cases of adenocarcinoma, four of small-cell carcinoma, and two of adenosquamous carcinoma. The demographic characteristics of the two groups were not significantly different (P > 0.2). The tumor size in RTCC was smaller than those in CTCC (P < 0.05). Hypoechoic lesions in CTCC and isoechoic lesions in RTCC composed 74.42% (32/43) and 61.90% (13/21), respectively (P < 0.001). Exophytic in CTCC and endophytic in RTCC composed 67.44% (29/43) and 66.67% (14/21), respectively (P = 0.01). HPV infection composed 83.72% (36/43) in CTCC and 47.62% (10/21) in RTCC, respectively (P = 0.003). Color Doppler blood signals were found in all cases, as compared with normal cervical tissue. The consistency between ultrasonography and pathology staging diagnosis of RTCC was good (Weighted kappa (95%CI) = 0.87).CONCLUSION: Most of patients in RTCC have isoechoic lesions. There is a good consistency between ultrasonography and pathology staging diagnosis of RTCC.

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Primary malignant melanoma of the cervix: 14 cases and literature overview

Cited by 11 publications

References 40 publications

Primary Melanoma of the Cervix Uteri: A Systematic Review and Meta-Analysis of the Reported Cases

Primary Melanoma of the Cervix Uteri: A Systematic Review and Meta-Analysis of the Reported Cases

Ultrasonographic diagnosis in rare primary cervical cancer

Ultrasonographic Diagnosis of Rare Primary Cervical Cancer

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