Primary malignant melanoma of the parotid gland: A case report and review of the literature

Chaouki, Anass; Berrada, Omar; Najib, Zouhair; Oukessou, Youssef; Abada, R.; Rouadi, Sami; Roubal, M.; Mahtar, M.

doi:10.1016/j.amsu.2020.11.085

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…Therefore, most of them were not clearly distinguished from benign salivary gland tumors such as pleomorphic adenoma, making it difficult to detect MM before biopsy. Although the patient number is small, hints of diagnosis were obtained from iso to high T1 signal in cases where MR was performed ( 10 , 17 ), including this case. Hyperintense T1 signal in the MM indicated the paramagnetic effect of melanin and its accompanying hemorrhage ( 20 ).…”

Section: Discussionmentioning

confidence: 96%

“…In addition, the presence of melanocytes in the normal parotid gland supports the possibility of primary MM of parotid glands ( 6 , 7 ). Although rare, some studies reported primary MMs of the parotid gland characterized by poor prognosis and difficult delayed diagnosis ( 8 – 10 ). However, there has been no report of MM in the parotid duct until now.…”

Section: Introductionmentioning

confidence: 99%

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Primary malignant melanoma of the parotid gland, a rare case arising from a duct: a case report and literature review

Aung,

Kim,

Yoon

et al. 2024

Front. Oncol.

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Malignant melanoma of the parotid gland is an unusual tumor in the head and neck region, and most parotid melanoma is reported as a metastatic lesion of cutaneous malignant melanoma. We report a case of primary malignant melanoma arising in the parotid gland duct with diagnostic challenge. The patient was a 68-year-old man who complained of repeated right facial swelling that presented 3 months prior. Swelling was detected along the Stensen’s duct of the cheek, and brown-colored saliva-like fluid was aspirated. On MR and CT images, a fluid-filled duct with small nodule and heterogeneously enhancing mass in the parotid parenchyma was detected. The nodular mass on the ductal wall grew rapidly, and the hyperintense T1 signal became significant on follow-up images. The final diagnosis via histopathologic examination using biopsy and parotidectomy specimen revealed the lesion as malignant melanoma of the duct and pleomorphic adenoma of the parenchyma. Even if the incidence of primary malignant melanoma is very low among tumors occurring in the parotid gland, efforts supporting an early diagnosis using imaging characteristics are important.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Primary malignant melanoma of the parotid gland, a rare case arising from a duct: a case report and literature review

Aung,

Kim,

Yoon

et al. 2024

Front. Oncol.

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“…Other cases [36][37][38][39][40][41][42] were adequately studied and fully fulfilled selection criteria [19] of primary melanoma of salivary glands. They are presented in Tables 2 and 3.…”

Section: Discussionmentioning

confidence: 99%

Is Primary Poorly Differentiated Sarcomatoid Malignancy of the Parotid Gland Sarcomatoid Undifferentiated/Dedifferentiated Melanoma? Report of Three Unusual Cases Diagnosed by Fine-Needle Aspiration Combined with Histological, Immunohistochemical, and Molecular Analyses

Klijanienko,

Masliah-Planchon,

Choussy

et al. 2024

Acta Cytologica

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Introduction: Poorly differentiated primary sarcomatoid parotid malignancies are extremely rare. These tumors have not been consistently studied by morphology, immunohistochemistry, or molecular techniques. Case Presentation: We report three unusual cases of parotid gland poorly-differentiated sarcomatoid malignancy investigated by fine-needle aspiration and studied histologically, by immunohistochemistry and molecular investigations. Aspirates showed poorly specific polymorphous sarcomatoid malignancy in all cases. Histologically, all cases were polymorphous high-grade malignancies, and additionally, one case showed epithelial structures and was finally classified as salivary carcinosarcoma. Immunohistochemistry showed classical melanocytic markers negativity but positivity for PRAME, CD10, and WT1 in all three tumors and for CD56 in two tumors, which can potentially be supportive of melanocytic origin. Although not entirely specific, molecular characterization also suggested the melanocytic lineage of these tumors. Conclusion: Although rare, primary malignant melanoma of salivary gland was already described, but undifferentiated/dedifferentiated amelanotic forms are unknown in this localization up today. Further case reports of similar presentations are required to confirm the unequivocal primary origin of these obscure neoplasms in the parotid gland.

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Primary Malignant Melanoma in the Parotid Gland: A Case Report and Literature Review

Yan,

Duan,

et al. 2024

Ear Nose Throat J

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Primary melanoma of the parotid gland is an extremely rare and challenging tumor with a poor prognosis, and its ultrasonic characteristics have yet to be reported. This article presents a case of a 77-year-old man with a left parotid mass that was confirmed as a melanoma following surgery. The ultrasonic features of melanoma were examined in detail, with a particular focus on their diagnostic value. Furthermore, we summarized the clinical characteristics, treatment options, and outcomes associated with primary melanoma of the parotid gland based on a thorough analysis of the available literature.

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Primary malignant melanoma of the parotid gland: A case report and review of the literature

Cited by 7 publications

References 18 publications

Primary malignant melanoma of the parotid gland, a rare case arising from a duct: a case report and literature review

Primary malignant melanoma of the parotid gland, a rare case arising from a duct: a case report and literature review

Is Primary Poorly Differentiated Sarcomatoid Malignancy of the Parotid Gland Sarcomatoid Undifferentiated/Dedifferentiated Melanoma? Report of Three Unusual Cases Diagnosed by Fine-Needle Aspiration Combined with Histological, Immunohistochemical, and Molecular Analyses

Primary Malignant Melanoma in the Parotid Gland: A Case Report and Literature Review

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