Primary Malignant Melanoma of the Urinary Bladder

Ammari, Jalal Eddine El; Ahallal, Y.; Fassi, Mohammed Jamal El; Farih, Moulay Hassan

doi:10.1155/2011/932973

Cited by 11 publications

(15 citation statements)

References 11 publications

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“…The function of melanocytes in mucosal membranes is still not known, but it cannot be protection from UV light. Mucosal tissue all over the body may be affected, except the ureters, where primary mucosal melanoma has never been reported .…”

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confidence: 99%

Mucosal malignant melanoma – a clinical, oncological, pathological and genetic survey

Mikkelsen

Larsen

Buchwald

et al. 2016

APMIS

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Mucosal melanomas constitute 1.3% of all melanomas and they may develop in any mucosal membrane. Conjunctival melanomas (0.5/million/year) and melanomas in the sinonasal cavity (0.5/million/year) are the most common, followed by anorectal melanomas (0.4/million/year) and melanomas in the oral cavity (0.2/million/year). Anorectal melanoma occurs slightly more often in females, whereas oral melanoma has a male predilection. Mucosal melanoma most commonly develops in a patient's sixth or seventh decade of life, and no differences between races have been found except for sinonasal melanoma and conjunctival melanoma, which are very rare in Black people. The symptoms are not tumour-specific and are related to the organ system affected, and the disease is most often diagnosed at an advanced clinical stage. The diagnosis of a primary tumour is difficult, and metastatic cutaneous melanoma and choroidal melanoma must be excluded. Mutations in KIT are frequently found, while BRAF and NRAS mutations are rarely found - except in conjunctival melanomas that carry BRAF mutations. Mutations in the TERT promotor region are also found in mucosal melanomas. Complete surgical resection with free margins is the treatment of choice. The prognosis is poor, with the 5-year survival rate ranging from 0% (gastric melanoma) to 80% (conjunctival melanoma).

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confidence: 99%

Mucosal malignant melanoma – a clinical, oncological, pathological and genetic survey

Mikkelsen

Larsen

Buchwald

et al. 2016

APMIS

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“…Transurethral resection of the lesion, partial cystectomy, radical cystectomy, chemotherapy, and radiation therapy had been used to treat melanoma of the urinary bladder. 6,11,12 It was stated by some authors that, in all patients with localised tumour, radical surgery seemed to be the therapy of choice, although to date none of the patients survived more than three years despite cystectomy characterizing the poor prognosis of the tumour. 13,14 TUR is a good option for treatment of small tumours, but always not adhering to the surgical principle of wide local excision.…”

Section: Discussionmentioning

confidence: 99%

Melanoma of Urinary Bladder presented as acute urine retention

Lamichhane¹,

Dhakal²

2017

Nep. J. Cancer

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This report is of a 50-year-old man with a rare urinary bladder melanoma. He presented with hematuria followed by bladder outlet obstruction at the time of presentation. Ultrasonogram of the pelvis revealed a mass in the bladder outlet, suggestive of enlarged prostate. Suprapubic cystostomy was then performed. Subsequent transvesical exploration revealed a dark coloured mass at the outlet of bladder, which on histopathology confirmed to be melanoma. After ruling out other possible primary sites, he underwent radical cysto-urethrectomy with urinary diversion. Disease was confirmed with immunohistochemistry. Patient died after 3 months with bilateral lung metastasis.

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“…El-Ammari et al [ 6 ] in 2011 reported a 71-year-old Moroccan male who presented with a 2-month history of gross haematuria. There was no past history of calculous disease or flank pain.…”

Section: Literature Reviewmentioning

confidence: 99%

“…The patient died five months later before any radical treatment could be performed. El-Ammari et al [ 6 ] stated that to their knowledge at the time of their publication in 2011 19 cases of primary melanoma of the urinary bladder had been reported worldwide in the literature.…”

Section: Literature Reviewmentioning

confidence: 99%

“…In 2006, Pacella et al [ 5 ] reported an 82-year-old patient who presented a local recurrence and died nine months after the diagnosis. The patient reported by El Ammari et al [ 6 ] died of widespread disease two months after diagnosis. However, Neiderberger reported 18 months disease-free survival in a primary bladder melanoma patient, who was treated with radical cystectomy alone [ 12 ].…”

Section: Literature Reviewmentioning

confidence: 99%

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Melanoma of the Urinary Bladder: A Review of the Literature

Venyo

2014

Surgery Research and Practice

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Background. Melanomas of the urinary bladder and urethra are rare. Aims. To review the literature on the disease. Methods. Various Internet databases were used to identify reported cases of the disease. Results. Less than 30 cases of primary melanoma of the urinary bladder and urethra have been reported in the literature and they have been associated with melanosis and commonly with metastases. The lesions may be primary or metastatic with no gender preference. The diagnostic features include pigmented raised lesions which histologically exhibit spindled or epitheliod cells, necrosis, mitotic figures, and atypical melanocytes. Immunohistochemically they stain positively with S100; HMB45; and other melanocyte markers, but negatively with Keratin and Vimentin. The treatment involves excision and possibly IL-2. The prognostic factors include size and depth of invasion as well as metastatic lesions. Conclusions. Less than 30 cases (about 24 cases) of the disease have been reported. There are also reports of metastatic melanomas of the urinary bladder emanating from primary melanomas originating elsewhere. Diagnosis of the primary disease is based upon the histological appearance of the lesion, positive staining with S100 and HMB45, and evidence of absence of melanoma elsewhere. Primary melanoma of the bladder is usually a fatal lesion.

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Primary Malignant Melanoma of the Urinary Bladder

Cited by 11 publications

References 11 publications

Mucosal malignant melanoma – a clinical, oncological, pathological and genetic survey

Mucosal malignant melanoma – a clinical, oncological, pathological and genetic survey

Melanoma of Urinary Bladder presented as acute urine retention

Melanoma of the Urinary Bladder: A Review of the Literature

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