Primary malignant mixed Müllerian tumour of the fallopian tube: a rare and difficult but possible diagnosis

Vale-Fernandes, Emídio; Rodrigues, Fedra; Serrano, Paula; Silva, Ana Isabel

doi:10.1136/bcr-2014-209268

Cited by 2 publications

(2 citation statements)

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“…Regarding the symptomatology at presentation, our results are in accordance with previous reports by reporting atypical vaginal bleeding and pelvic pain or discomfort, although there is no relevant evidence for which these symptoms may be correlated with prognosis. MMMTs can present, although rarely, as acute abdomen, cases in which are associated until the histological examination is performed; the most frequent preoperative and intraoperative diagnosis is related to an ovarian tumor, underlining its inaccuracy (67). Concerning imaging examination, MRI is more sensitive compared to CT to distinguish various tumor characteristics that may facilitate the preoperative diagnosis and further treatment, although imaging reports of carcinosarcoma of the fallopian tube are limited, as well as the role of CA125 (71).…”

Section: Discussionmentioning

confidence: 99%

“…MMMTs can present, although rarely, as acute abdomen, cases in which are associated with torsion or rupture, leading to hemoperitoneum ( 64 , 66 ). Due to the common symptoms of MMMTs, rarity and localization, an initial definitive diagnosis is very difficult to achieve and prove, in the majority of cases remaining uncertain until the histological examination is performed; the most frequent preoperative and intraoperative diagnosis is related to an ovarian tumor, underlining its inaccuracy ( 67 ). Concerning imaging examination, MRI is more sensitive compared to CT to distinguish various tumor characteristics that may facilitate the preoperative diagnosis and further treatment, although imaging reports of carcinosarcoma of the fallopian tube are limited, as well as the role of CA125( 71 ).…”

Section: Discussionmentioning

confidence: 99%

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Malignant mixed Müllerian tumor of the fallopian tube: Case report and literature review

et al. 2021

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Carcinosarcoma, also known as malignant mixed Müllerian tumor (MMMT), includes both malignant epithelial and mesenchymal elements. While the endometrium is the most frequent known site for carcinosarcomas, their development in the fallopian tube is rare condition, only accounting for 0.1 to 0.5% among all gynecological malignancies. Fallopian tube MMMT is associated with an aggressive progression. A total of 94 previous case reports were reviewed and divided, after applying the exclusion criteria, into 2 groups: No evidence of disease (NED) Group including 33 patients reported to be without any residual disease at the end of the follow-up period; death of disease (DOD) Group including 51 patients who died due to the progression of fallopian carcinosarcoma or its complications. The gathered data were statistically analyzed together with a case from our clinical experience: a 65-year-old postmenopausal patient with a final histological diagnosis of fallopian carcinosarcoma staged FIGO IC2, synchronous with a serous endometrial intraepithelial carcinoma. Patient age between 41 and 60 years, symptoms at presentation and computed tomography (CT)/magnetic resonance imaging (MRI) tumor evidence are prognostic factors (P<0.05). Omentectomy [odds ratio (OR)=0.3545] and pelvic lymphadenectomy (OR= 0.3732) were found to be significant factors for survival (P<0.05). Fimbrial localization of the tumor is a negative prognosis factor (OR=4.263), as well as the heterologous type of tumor (OR=2.880). Chemotherapy was found to improve survival (OR=0.2679) while radiotherapy had no influence on patient prognosis. Reporting these rare cases could be essential for obtaining more precise information regarding the treatment and prognosis of patients with MMMT of the fallopian tube, in order to improve patient survival and quality of life.

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Section: Discussionmentioning

confidence: 99%