Primary malignant non-hodgkin lymphoma of the talus

Abstract

Primary bone lymphoma (PBL) is a relatively uncommon entity. It represents approximately 5% of all non-Hodgkin lymphomas (NHLs) and 3% of all bone malignancies. The femur, tibia, and pelvis are the most common skeletal sites involved. It can occur at any age, with a peak incidence in the fourth and fifth decades.The most common grade identified is intermediate, followed by low-grade lesions. It can mimic other disease processes, especially infection. So, thorough and prompt investigatory workup is essential for adequate treatment. Localized disease responds well to combined modality treatment with chemotherapy and radiotherapy and is associated with good prognosis. We discuss the clinical findings, diagnosis, and treatment in a case of PBL involving the talus. This is an unique clinical presentation owing to its unusual site.

Primary malignant lymphoma of the talus: A case report and review of the literature

“…The inguinal and popliteal lymph nodes were considered to be compatible with regional lymph node metastasis from the talus tumor. To the best of our knowledge, only 5 cases of PLB of the talus have been previously reported in the English literature, namely 1 case of multifocal and 4 cases of unifocal lesions, as in the present case ( Table I ) ( 3 , 8 , 11 – 13 ).…”

“…As PET/MRI has been reported to show higher sensitivity for detecting bone marrow involvement of ML compared with PET/CT and bone scintigraphy ( 19 , 20 ), PET/MRI is useful for detecting osseous involvement in ML, including PLB. Although 3 of the 5 previously reported cases did not undergo FDG PET scans ( 11 – 13 ), PET/MRI or PET/CT is quite useful for accurate staging of PLB, as well as evaluation of the therapeutic effects.…”

Diffuse large B-cell lymphoma mimicking chronic osteomyelitis of the ankle joint: A case report

“…1 However, primary bony lymphoma (PBL) subtype represents approximately 5% of all non-Hodgkin lymphomas (NHLs) and 3%–4% of all bone malignancies. 2 It can involve any part of the musculoskeletal system with the majority of cases reported arising in the lower extremity, particularly the thigh and calf regions. 3 It may present as a single bone lesion with or without an associated soft tissue mass arising from local extension, with or without regional lymphadenopathy or as a multifocal polyostotic disease exclusively involving the skeleton.…”

Primary non-Hodgkin’s lymphoma of the talus

“…A maioria dos casos de LPO apresenta padrão com linfoma difuso de grandes células B (DLBCL). A imuno-histoquímica mostra positividade para CD20, CD79a e Bcl-2 -marcadores para células da linhagem B e negatividade para CD3, CD5, CD10, CD23, ciclinaD1 e desoxinucleoti-diltranferase terminal -marcadores para células da linhagem T ou células foliculares (5)(6) . O linfoma difuso de grandes células B é o mais comum dos subtipos histológicos, correspondendo a aproximadamente 80% dos casos, seguido então pelas células foliculares, linfoplasmocíticas, anaplásicas, células NK / T, linfoma de Burkitt, outros linfomas indolentes e linfoma de Hodgkin (7) .…”