Primary malignant tumors of the liver

Abstract

Over a span of 20 years, 137 patients with primary malignant tumors of the liver received treatment at the Memorial Cancer Center. Seventy‐one percent of the patients had hepatocellular carcinoma. Various modalities of therapy were applied in the treatment of these patients. Early diagnosis is mandatory to increase the resectability rate. Thirty‐two patients had some form of hepatic resection of whom 5 survived more than 5 years. Good palliation and prolongation of life occurred in 2 out of 6 patients who had hepatic artery infusion by chemotherapeutic agents. The role of hepatic transplantation and re‐vascularization of segments of the liver in extending the scope of hepatic resection remains in the experimental phase.

Hepatocellular carcinoma in port Harcourt, Nigeria: Clinicopathologic study of 75 cases

“…It is frequent in the sub-Saharan Africa and South East Asia where it is responsible for a large proportion of cancer deaths but is rare in USA and Europe. 2 The high incidence rate may be related to the high prevalence of Hepatitis B viral (HBV) infection, aflatoxin B 1 contamination and some hepatotoxic drugs. 3,4 Hepatitis C virus (HCV), cigarette smoking and alcohol are also etiologic agents in this environment.…”

Cutaneous and Colonic Metastases After Resection of Hepatocellular Carcinoma

“…Gastrointestinal metastases of HCC are also uncommon, affecting from 3 to 8% of patients in an autopsy series [17][18][19]. Most of these metastases appear to occur by local invasion of the stomach or small bowel.…”

New, Effective Treatment Using Proton Irradiation for Unresectable Hepatocellular Carcinoma.

“…The quantity of radiation was 3-4 Gy per treatment and the (3)(4)(5)(6). It has been assumed that more than 50 Gy should be targeted for killing HCCcells (7). But the conventional approaches in which the whole liver is irradiated have caused radiation hepatitis and eventual hepatic failure, especially in patients complicated with cirrhosis.…”

“…But the conventional approaches in which the whole liver is irradiated have caused radiation hepatitis and eventual hepatic failure, especially in patients complicated with cirrhosis. Therefore, sufficient irradiation of a large quantity and long duration to obtain effective antineoplastic effects for mostcases of HCChas not been possible (6)(7). Unlike the conventional radiation beam, the proton beam has a unique beamdistribution: the beam distribution rate is less in deeper sites than in thinner, superficial sites and there is a peak area (Bragg peak) which rapidly stands around the end of the range at a specific depth-responding energy.…”