Primary MALT Lymphoma of the Larynx

Macías-Rodríguez, Diego Hernando; Blanco-Pérez, Pedro; Ruíz, Santiago Santa Cruz; Batuecas‐Caletrío, Ángel

doi:10.1016/j.otoeng.2013.11.020

Acta Otorrinolaringologica (English Edition)

2015

DOI: 10.1016/j.otoeng.2013.11.020

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Primary MALT Lymphoma of the Larynx

Diego Hernando Macías-Rodríguez

Pedro Blanco-Pérez

Santiago Santa Cruz Ruíz

et al.

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Cited by 2 publications

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Extranodal marginal zone lymphoma of the larynx: A case report and scoping review

Werner,

Cooper,

Kaplan

2024

Head & Neck

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BackgroundThis scoping review aims to review cases of extranodal marginal zone lymphoma (MZL) of the larynx to establish best management practices for this rare clinical entity.MethodsIn this paper, we report a case of laryngeal MZL, in accordance with CARE guidelines. We then performed a scoping review according to PRISMA‐ScR criteria of published cases of MZL involving the larynx. The following data were collected for each case: age, sex, size, location(s) involved, stage, treatment, follow‐up, and recurrence duration.ResultsSixty‐six patients with laryngeal MZL, first reported in 1990, were identified. Characterized by its low‐grade histological appearance and indolent course, laryngeal MZL is generally confined to the larynx and has an excellent prognosis with radiation used as first‐line therapy.ConclusionsIt is imperative for clinicians to consider lymphoma in the differential diagnosis of a laryngeal tumor from any subsite, as certain pathologies may carry high risks of metastasis.

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Extranodal marginal zone lymphoma of the larynx: A case report and scoping review

Werner,

Cooper,

Kaplan

2024

Head & Neck

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Mucosa-Associated Lymphoid Tissue Lymphoma of the Larynx

Rizvi

Nielsen

Bearelly

2020

Case Reports in Otolaryngology

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Background. Mucosa-associated lymphoid tissue (MALT) lymphomas are a subtype of non-Hodgkin lymphoma stemming from marginal zone B-cells. In this case report, we present two patients with an extremely rare localization of MALT lymphoma to the larynx. Methods. Case 1 is of a 78-year-old male presenting with a six-month history of progressive hoarseness with a past medical history significant for marginal zone lymphoma of the right orbit. Diagnosis was confirmed with a biopsy for extranodal marginal zone B-cell lymphoma of MALT type. An FDG-PET scan was done but did not show any sign of FDG avid malignancy, including at the primary site. Case 2 is a 60-year-old female presenting with one year of worsening throat discomfort, intermittent cough, and dyspnea with exertion. Pathology confirmed a diagnosis of extranodal marginal zone B-cell lymphoma of MALT type. Results. Case 1 was treated with low-dose radiation at 4 Gy delivered over two fractions of 2 Gy each. Upon completion of radiation treatment, he reported a resolution of his hoarseness and normalization of his voice. A four-month follow-up in May 2018 with flexible nasolaryngoscopy revealed a normal exam with fully mobile vocal folds bilaterally and no evidence of left false vocal fold submucosal mass. At seven months following treatment, the patient died unexpectedly of unknown causes. Case 2 was treated with radiation at 30 Gy in 15 fractions over the course of one month. Following completion of radiation therapy, she had improvement of her sore throat, nausea, dysphagia, dysgeusia, and dry mouth. At 21-month follow-up, she had no evidence of disease. Conclusion. This case report demonstrates that MALT lymphoma can present with much more benign and subtle symptoms. This highlights the importance of clinicians to keep broad differentials and consider MALT lymphomas in the setting of laryngeal masses.

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Primary MALT Lymphoma of the Larynx

Cited by 2 publications

References 9 publications

Extranodal marginal zone lymphoma of the larynx: A case report and scoping review

Extranodal marginal zone lymphoma of the larynx: A case report and scoping review

Mucosa-Associated Lymphoid Tissue Lymphoma of the Larynx

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