Primary mantle cell lymphoma of the nasopharynx: a rare clinical entity

Kang, Ji-Hun; Park, Young-Dae; Lee, Chang‐Hoon; Cho, Kyu‐Sup

doi:10.1016/j.bjorl.2015.02.002

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…3,6 Patients usually present at later stages of the disease with extensive lymph nodes, liver, spleen, and bone marrow involvement. 5 Like NHL, staging of this illness is done using the Ann Arbor system. Approximately 5% to 15% of patients will present with limited stage I and II disease.…”

Section: Discussionmentioning

confidence: 99%

“…6 Frequent relapse after completing chemotherapy has been reported. 1-3,5 Due to the mentioned reasons, MCL has a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, no more than five cases of nasopharyngeal MCL have been reported in the English literature, and none of the cases reported relapse to involve the nasopharynx. 1-5…”

Section: Introductionmentioning

confidence: 99%

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Nasopharyngeal Mantle Cell Lymphoma: An Extremely Rare Entity

Paul¹,

Asmi²,

Omar³

et al. 2019

Oman Med J

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Mantle cell lymphoma (MCL) is a rare, aggressive subtype of non-Hodgkin lymphoma with a poor prognosis and high recurrence rate. It seldom affects the Waldeyer’s ring let alone the nasopharynx. Patients usually present at late stages of the disease leading to poor failure-free and overall survival rates. Intensive chemotherapy regimes and autologous stem cell transplantation have reported increased survival rates. We report a relapsed case of nasopharyngeal MCL, which previously occurred in the gastrointestinal tract. The patient had undergone a hemicolectomy for colon intussusception secondary to the intraluminal lymphoma mass. He was unable to complete the treatment regime for MCL due to the adverse side effects. Oropharyngeal mass was discovered during routine outpatient follow-up, which was confirmed as nasopharyngeal MCL. We discuss the prognosis, disease progression, and possible treatments.

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Section: Discussionmentioning

confidence: 99%

“…6 Frequent relapse after completing chemotherapy has been reported. 1-3,5 Due to the mentioned reasons, MCL has a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Nasopharyngeal Mantle Cell Lymphoma: An Extremely Rare Entity

Paul¹,

Asmi²,

Omar³

et al. 2019

Oman Med J

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“…6 To the authors' knowledge, there have only been two incidences of primary nasopharyngeal MCL described in the literature with this case report being the third. 7,8 There are several retrospective reviews which separate various types of head and neck lymphomas by location. However, these reports have not reported any incidences of primary nasopharyngeal MCL.…”

Section: Introductionmentioning

confidence: 99%

When Snoring isn’t just Snoring: Primary Nasopharyngeal Mantle Cell Lymphoma - A Rare Pathology in the Nasopharynx.

Keidar

Shermetaro

2019

Spartan Medical Research Journal

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Snoring is a common complaint in the primary care and otolaryngology clinic with a wide differential diagnosis. Primary nasopharyngeal mantle cell lymphoma is a rare cause of a nasopharyngeal mass, which can commonly manifest as snoring. The patient in this case presented with extensive history of recent worsening snoring as well as nasal congestion over the past several months. Additionally, the patient had previously undergone endoscopic sinus surgery several years prior but was lost to follow up. During nasal endoscopy, a nasopharyngeal mass was visualized with near-complete obstruction of the nasal airway. Intraoperative biopsies indicated MCL which is an uncommon pathology presenting in a rare location. Flow cytometry of the biopsy specimen was CD19+, CD20+, CD5+, and positive for lambda light chains with immunohistochemistry showed strong diffuse cyclin D1 nuclear staining on lymphoid cells. PET/CT and bone marrow biopsy were essential in staging disease, predicting success of treatment, and determining optimal treatment planning. Once the diagnosis was established, R-CHOP therapy alternating with R-DHAP for a total of six cycles. This case report highlights the importance of recognizing new or changing symptoms, appropriate diagnostic workup for lymphoma, as well as one of few case reports describing primary nasopharyngeal mantle cell lymphoma.

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“…The nasopharynx is a commonly involved site of the lymphoma. Cases of it have been reported from countries as far apart as China [1][2][3][4], Hong Kong [5], India [6,7], Korea [8], Morocco [9], Tunisia [10], and USA [11]. Therefore, this paper deals with the Nigerian cases with special reference to the Ibo ethnic group [12].…”

Section: Introductionmentioning

confidence: 99%