Primary Meningeal Malignant Fibrous Histiocytoma with Cerebrospinal Dissemination and Pulmonary Metastasis

Akimoto, Jiro; Takeda, Yuichiro; Hasue, Masamichi; Ito, Hiroshi; Kiguchi, Eiko

doi:10.1007/s007010050236

Cited by 20 publications

(5 citation statements)

References 13 publications

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“…A few of the published reports of primary intracranial MFH have included MRI findings in their description of the tumor; however, the MRI findings were limited to conventional magnetic resonance (MR) sequences, such as T1‐ and T2WI and contrast‐enhanced T1WIs 1–3,8,9 . Central necrosis and surrounding edema, as observed on T2WIs, revealed markedly high and intermediately high signal intensity, respectively.…”

Section: Discussionmentioning

confidence: 99%

Primary Intracerebral Malignant Fibrous Histiocytoma: CT, MRI, and PET‐CT Findings

Yoo

Choi²,

Park³

et al. 2011

Journal of Neuroimaging

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Primary intracranial malignant fibrous histiocytoma (MFH) is an extremely rare entity. A few reported cases have been associated with factors such as a previous history of radiation therapy or surgical trauma. We report on a rare case of intracerebral MFH in a previously healthy 47-year-old man, which was initially presumed to be a high-grade glioma. Conventional as well as advanced magnetic resonance sequences, including diffusion-weighted image and perfusion-weighted image, were used in characterization of the mass.

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Section: Discussionmentioning

confidence: 99%

Primary Intracerebral Malignant Fibrous Histiocytoma: CT, MRI, and PET‐CT Findings

Yoo

Choi²,

Park³

et al. 2011

Journal of Neuroimaging

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“…Even with aggressive chemotherapy and radiation, median survival was only 27 months due to local progression with occasional metastasis and cerebrospinal fluid dissemination according to Hamlat et al’s series [8]. Doxorubicin and ifosfamide have been used in the treatment of intracranial UPS due to their activity against soft tissue sarcomas as reported by Akimoto et al [9]. Ham et al, reviewed the use of a high-dose methotrexate-based regimen in 17 cases of bone UPS, and they found that it dropped the recurrence/metastasis rate from occurring at an average of 17 months to no recurrence during an average follow-up period of 10 years.…”

Section: Discussionmentioning

confidence: 99%

Intraventricular Undifferentiated Pleomorphic Sarcoma: A Case Report

Sieg¹,

Stepanyan²,

Payne³

et al. 2016

Cureus

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Undifferentiated pleomorphic sarcoma is a histologic diagnosis based on cell morphology. These tumors are found throughout the body. They are rarely found in the central nervous system and almost never occur as a primary intraventricular tumor. We present the unusual case of a 68-year-old woman with an intraventricular undifferentiated pleomorphic sarcoma. We go on to discuss the clinical presentation, radiographic characteristics, and management paradigm for these rare lesions. Our patient presented with acute confusion, inability to balance a checkbook, and gait imbalance. CT and MRI demonstrated a 4 x 3.6 x 3.6 cm enhancing lesion in the left lateral ventricle abutting the foramen of Monro. Pathology revealed an undifferentiated pleomorphic sarcoma.

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“…Intracranial MFH does not have specific radiological features on MRI and CT images due to its variable degrees of histological differentiation [15] . Arteriography of the tumor can be vascular or avascular [34,35] . Tumors appear hypermetabolic on PET-CT scan, just like other malignant tumors [15] .…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Prognostic Factors of Primary Intracranial Malignant Fibrous Histiocytoma: A Report of 8 Cases and a Literature Review

Zhou

Yang

Wang

et al. 2016

Translational Neuroscience and Clinics

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Objective Primary intracranial malignant fibrous histiocytoma (MFH) is rare. We describe the detailed clinical features of 8 cases and fully review the literature to evaluate several prognostic factors. Methods Eight patients with pathologically confirmed primary intracranial MFH were retrospectively reviewed. We searched PubMed for relevant articles with the term “intracranial malignant fibrous histiocytoma”. Results Of the 8 patients, 4 were men and 4 were women. Three patients had received previous radiotherapy. The age of the patients ranged from 19 to 69 years, with a median age of 48 years. Most tumors could be totally resected; and only 1 tumor was subtotally resected. Six patients received postoperative radiotherapy and 3 patients received postoperative chemotherapy. Most patients died within the first year after surgery; and only 1 patient was still alive on the date of the last follow-up. We reviewed the literature and included a total of 46 patients in the Kaplan-Meier survival analysis. Young patients (less than 30 years old) seemed to have a better prognosis and survival rate than older patients (more than 30 years old) (log-rank test, P = 0.008). However, sex (P = 0.675), extent of resection (P = 0.934), postoperative radiotherapy (P = 0.592), and postoperative chemotherapy (P = 0.424) did not affect patient prognosis. Conclusions The prognosis of MFH is usually poor, and most patients die within the first year after surgery. Younger MFH patients (less than 30 years old) seem to have a better prognosis and improved survival compared to older patients.

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Primary Meningeal Malignant Fibrous Histiocytoma with Cerebrospinal Dissemination and Pulmonary Metastasis

Cited by 20 publications

References 13 publications

Primary Intracerebral Malignant Fibrous Histiocytoma: CT, MRI, and PET‐CT Findings

Primary Intracerebral Malignant Fibrous Histiocytoma: CT, MRI, and PET‐CT Findings

Intraventricular Undifferentiated Pleomorphic Sarcoma: A Case Report

Clinical Features and Prognostic Factors of Primary Intracranial Malignant Fibrous Histiocytoma: A Report of 8 Cases and a Literature Review

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