Primary meningeal melanomatosis: limitations of current diagnostic techniques.

Grant, D N

doi:10.1136/jnnp.46.9.874

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Primary leptomeningeal melanomatosis is more common in adults (peak prevalence, 4th decade of life) than in children, and patients present with variable signs and symptoms including seizures, signs of increased intracranial pressure, psychiatric disturbances, cranial nerve palsies, and spinal cord compression (50,51). The ante mortem diagnosis of primary leptomeningeal melanomatosis can be challenging, because it may be diffi cult to recognize on radiologic images, and the isolated tumor cells within the CSF may be hard to recognize at cytologic analysis (52,53).…”

Section: Primary Leptomeningeal Melanomatosismentioning

confidence: 99%

Pigmented Lesions of the Central Nervous System: Radiologic-Pathologic Correlation

Smith¹,

Rushing²,

2009

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Pigmented lesions of the central nervous system (CNS) are a diverse group of entities that run the gamut from benign to malignant. These lesions may be well circumscribed or diffuse, and their imaging appearances are influenced by the degree of melanin content as well as the presence or absence of hemorrhage. Pigmented lesions include primary melanocytic lesions of the CNS and metastatic melanoma, as well as other CNS neoplasms that may undergo melanization, including schwannoma, medulloblastoma, and some gliomas. Primary melanocytic lesions of the CNS arise from melanocytes located within the leptomeninges, and this group includes diffuse melanocytosis and meningeal melanomatosis (seen in neurocutaneous melanosis), melanocytoma, and malignant melanoma. Primary melanin-containing lesions of the CNS must be differentiated from metastatic melanoma because these lesions require different patient workup and therapy. Absence of a known primary malignant melanoma helps in the differential diagnosis, but an occult primary lesion outside the CNS must be sought and excluded. Pigmented lesions of the CNS are uncommon, and knowledge of their imaging characteristics and pathologic features is essential for their identification.

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Section: Primary Leptomeningeal Melanomatosismentioning

confidence: 99%

Pigmented Lesions of the Central Nervous System: Radiologic-Pathologic Correlation

Smith¹,

Rushing²,

2009

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“…2 L e p t o m e n i n g e a l m e l a n o m a t o s i s : P r i m a r y leptomeningeal melanomatosis is a rare, diffuse neoplasm of the CNS that arises from melanocytes within the leptomeninges. It is also referred to as a meningeal variant of primary malignant melanoma (38). However, the morphological characteristics of leptomeningeal melanomatosis are diffuse darkening and thickening of the leptomeninges in the gross specimen.…”

Section: Differential Diagnosismentioning

confidence: 99%

Primary cervicothoracic melanoma of spinal cord: a case report and literature review

Dang,

Du,

Wei

et al. 2024

Front. Oncol.

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A 53-year-old male patient presented progressive numbness and weakness in the right limbs for a 2-year duration. Magnetic resonance imaging scans revealed an intramedullary lesion crossed over cervical and thoracic levels accompanied by syringomyelia at the proximal end of the lesion. The patient underwent subtotal resection of the neoplasm. The histological findings of the tumor were consistent with primary intramedullary malignant melanoma and not initial ependymoma after careful dermatologic and ophthalmologic re-examination. Primary melanoma of the spinal cord, particularly cervicothoracic localization with syringomyelia, is seldom reported in the literature. We report a case of this uncommon tumor and also discuss the clinical course, diagnosis, and treatment.

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Primary Amelanotic Leptomeningeal Melanomatosis in a Child: A Rare but Severe Disease

et al. 2016

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Primary meningeal melanomatosis: limitations of current diagnostic techniques.

Abstract: Table Lumbar puncture results: Day I Day 2 Day 18 Appearance turbid fluid slightly xanthochromic clear fluid Pressure cm 23 23 Protein g/l 3-4 4-8 9 Globulin mod increase mod increase mod increase Glucose mmol/l C.S.F. (serum) 45 (14-2) 3-5 (13-3) 2-8 (9-0) Chloride mmol/l 113

Cited by 4 publications

References 12 publications

Pigmented Lesions of the Central Nervous System: Radiologic-Pathologic Correlation

Pigmented Lesions of the Central Nervous System: Radiologic-Pathologic Correlation

Primary cervicothoracic melanoma of spinal cord: a case report and literature review

Primary Amelanotic Leptomeningeal Melanomatosis in a Child: A Rare but Severe Disease

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