Primary monophasic synovial sarcoma of the pleura: diagnosis and treatment

Loscertales, Jesús; Triviño-Cabrera, Alicia; Gallardo, Gregorio; Congregado, Miguel

doi:10.1510/icvts.2010.259531

Cited by 14 publications

(7 citation statements)

References 11 publications

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“…In the absence of typical clinical manifestations and signs, the early diagnosis of the disease often depends on the results of imaging examinations. CT scans of mediastinal SS showed a soft tissue density shadow, lobulated appearance, clear edge, homogeneous enhancement, and liquefaction necrosis in the tumor, but these findings are often difficult to differentiate from those of solitary fibroma, leiomyosarcoma and rhabdomyosarcoma (23)(24)(25). In our study, 2 cases of mediastinal SS were not biopsied before surgery, one of which was submitted to an MDT meeting for discussion before surgery, and SS was considered.…”

Section: Discussionmentioning

confidence: 70%

The value of multidisciplinary team (MDT) management in the diagnosis and treatment of primary intrathoracic synovial sarcomas: a single-center experience

Yang

Peng

et al. 2021

J Thorac Dis

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Background: Synovial sarcoma (SS) is a rare malignant soft tissue tumor. Primary intrathoracic SS is extremely rare, with limited diagnosis and treatment experiences. The aim of our study was to retrospectively study the clinicopathological characteristics, treatment and prognosis of primary intrathoracic SS and the impact of multidisciplinary team (MDT) management in diagnosis and treatment on patient prognosis. Methods: The clinical and pathological characteristics, treatment, survival and prognosis of patients with primary intrathoracic SS admitted to the National Cancer Center from January 1999 to December 2018, as well as MDT intervention during diagnosis and treatment, were retrospectively analyzed. Results: Thirteen patients were enrolled, including 7 (53.8%) males and 6 (46.3%) females, with primary intrathoracic SS in the lung (8/13, 61.5%), mediastinum (4/13, 30.8%) and pleura (1/13, 7.7%) as confirmed by morphological observation, immunohistochemical (IHC) staining and fluorescence in situ hybridization (FISH). Overall, 10/13 (76.9%) patients underwent surgery, and 6/10 (60.0%) received postoperative adjuvant therapy. Only 23.1% of patients received nonsurgical therapy. The MDT discussed and managed seven patients before and/or after surgery and one patient who did not undergo surgery. The estimated 3and 5-year overall survival (OS) rates were 50.0% and 30.0%, respectively. Patients who were managed by an MDT had a longer median OS time than those who were not (46.0 vs. 18.0 months). Age (P=0.018), tumor location (P=0.029), and Ki-67 (P=0.020) were found to be significantly related to OS.Conclusions: Monophasic morphology and fusion gene characteristics are the main features for the diagnosis of primary intrathoracic SS. MDT management can help obtain accurate diagnoses and provide reasonable therapeutic options.

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Section: Discussionmentioning

confidence: 70%

The value of multidisciplinary team (MDT) management in the diagnosis and treatment of primary intrathoracic synovial sarcomas: a single-center experience

Yang

Peng

et al. 2021

J Thorac Dis

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“…However, other groups have applied similar treatment to that used in the present study in synovial sarcomas occurring at other sites (12). Primary pleural synovial sarcoma has a high recurrence rate compared to other sarcomas.…”

Section: Discussionmentioning

confidence: 89%

Primary Pleural Synovial Sarcoma Treated with Pazopanib

et al. 2015

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A 42-year-old woman presented with chest pain and breathlessness with a nodule measuring 2×2 cm in size at the base of the right lung. A bronchoscopic examination did not reveal any malignancy. However, the patient developed difficulty in breathing, enlargement of the nodule, and right pleural effusion 14 days later. A video-assisted thoracic surgical biopsy specimen revealed the presence of pleural synovial sarcoma. The patient was treated with doxorubicin-ifosfamide combination chemotherapy because of metastasis to the pelvis. However, after a transient partial clinical response, there was a relapse of refractory disease. Although treated with pazopanib as second-line chemotherapy, the patient died eight months after the initial presentation.

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“…However, Baccari-Ezzine et al (12) reported a case of intracardiac metastasis at the apex of the right ventricle from primary SS in the lungs. Although primary pleural SS is rare, this condition has been documented (13,14); therefore, it is possible that our patient had primary pleural SS with intravascular metastasis.…”

Section: Discussionmentioning

confidence: 89%

Intravascular Synovial Sarcoma of the Pulmonary Artery with Massive Pleural Effusion: Report of a Case with a Favorable Response to Ifosfamide Chemotherapy and Palliative Radiation Therapy

et al. 2015

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Synovial sarcoma (SS) commonly arises in the para-articular soft tissue; however, very few cases of intravascular SS have so far been reported. We herein describe a case of pulmonary artery SS with massive pleural effusion. A biopsy of the pleural lesions showed uniform short spindle cell proliferation, while the SYT-SSX fusion gene, which is preceded by chromosomal translocation t(X;18)(p11;q11), was detected using reverse transcription-polymerase chain reaction. Treatment with ifosfamide chemotherapy and palliative radiation therapy was effective in reducing the growth of the tumor in the pulmonary artery and pleural lesions, indicating that this regimen may be useful for the treatment of unresectable SS in the pulmonary artery.

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Primary monophasic synovial sarcoma of the pleura: diagnosis and treatment

Cited by 14 publications

References 11 publications

The value of multidisciplinary team (MDT) management in the diagnosis and treatment of primary intrathoracic synovial sarcomas: a single-center experience

The value of multidisciplinary team (MDT) management in the diagnosis and treatment of primary intrathoracic synovial sarcomas: a single-center experience

Primary Pleural Synovial Sarcoma Treated with Pazopanib

Intravascular Synovial Sarcoma of the Pulmonary Artery with Massive Pleural Effusion: Report of a Case with a Favorable Response to Ifosfamide Chemotherapy and Palliative Radiation Therapy

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