Primary Mucinous Adenocarcinoma of a Seminal Vesicle Cyst Associated with Ectopic Ureter and Ipsilateral Renal Agenesis: a Case Report

Abstract

Primary adenocarcinoma of the seminal vesicles is a rare neoplasm. Congenital seminal vesicle cysts are commonly associated with unilateral renal agenesis or dysgenesis. To the best of our knowledge, mucinous adenocarcinoma of the seminal vesicle cyst that's associated with an ectopic ureter opening into the seminal vesicle and ipsilateral renal agenesis has not been described in the radiological literature. We report here on the radiological findings of a primary adenocarcinoma of a seminal vesicle cyst in this condition.rimary tumors of the seminal vesicles are rare. Primary adenocarcinoma of the seminal vesicles commonly occurs in patients who over the age of 50. Congenital anomalies of the mesonephric duct are rare in males. Congenital seminal vesicle cysts are commonly associated with ipsilateral renal agenesis or dysgenesis (1). We present here the imaging findings of a primary adenocarcinoma of a seminal vesicle cyst associated with an ectopic ureter opening into a seminal vesicle and ipsilateral renal agenesis. CASE REPORTA 41-year-old man presented with terminal gross hematuria that was noted one month earlier. His past medical history was unremarkable except that he had suffered with prostatitis. The serum markers for prostate cancer, prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP) were normal. Carcinoembryonic antigen (CEA) was also in the normal range. Transrectal ultrasonography showed a well-demarcated, pear-shaped cystic lesion that included an echogenic papillary solid mass in his left seminal vesicle (Fig. 1A). Contrast-enhanced pelvic CT showed that the papillary solid mass originated from the wall of the left seminal vesicle cyst and it was mildly enhanced (Fig. 1B). A dilated ectopic ureter opening into the dilated left seminal vesicle was also seen. There was no evidence of any other pelvic tumors. Contrast enhanced abdominal CT at the level of the L4 vertebra demonstrated a small abnormal soft tissue density in the aorta's left lateral aspect, suggesting a dysgenetic or atrophic kidney (Fig. 1C). The axial T1-weighted (TR/TE: 540/12 ms) MR image showed high signal-intensity fluid in the seminal vesicle cyst (Fig. 1D). The coronal T2-weighted (TR/TE: 5500/136 ms) MR image demonstrated an approximately 7.8 6 5.2 cm papillary mass in the left seminal vesicle cyst (Fig. 1E). The sagittal T2-weighted image showed a markedly dilated ectopic ureter draining into the cyst (Fig. 1E). The cystoscopic findings showed bulging of the left hemitrigone on the left side of the bladder. The left ureteral orifice was absent.Radical excision of the left agenetic kidney, left ureter and seminal vesicle cyst and a

Primary seminal vesicle adenocarcinoma: A case report of rare entity and discussion of its differential diagnosis using immunohistochemical approach for the core biopsy specimen

“…The mean age of presentation is 62 years (range, 17-90 years). Exact aetiology is not known due to paucity of data; however, some reports have related its pathogenesis to congenital urinary tract abnormalities like renal agenesis and ectopic ureter (Byung, Jung, Yoon, Yong, & Soon, 2007). It is notable that our patient had unilateral renal agenesis.…”

Squamous Cell Carcinoma of the Seminal Vesicle from Zinner Syndrome: A Case Report and Review of Literature

“…MRKH syndrome is reportedly associated with ovarian cancer and renal cell carcinoma in the genitourinary tract [ 6 , 7 ]. Two cases of adenocarcinoma arising from a seminal vesicle cyst in Zinner syndrome patients have been previously reported [ 8 , 9 ]. Table 1 summarizes those cases as well as the present case.…”

A case of Zinner’s syndrome (seminal vesicle cyst with ipsilateral renal agenesis) presenting antenatally

“…As typified in our case, histologically the cysts are usually found to be lined with columnar epithelium, typical of seminal vesicles. There have been reports in adults of primary seminal vesicle adenocarcinoma in the abnormally formed seminal vesicles found in Zinner's syndrome [30,31]. There is also a report of Zinner's syndrome in conjunction with papillary carcinoma of the bladder in a 37-year-old with no risk factors for bladder cancer, and it was postulated that irritation of the bladder by the cyst could be a contributory factor in the pathogenesis of the papillary tumour [32].…”