Primary mucinous carcinoma of the skin: a case of metastasis after 10 years of disease-free interval

Miyasaka, Muneo; Tanaka, Reika; Hirabayashi, Kenichi; Yamazaki, Akira; Shinohara, Hideki; Taira, Hiroyuki; Akamatsu, Tadashi

doi:10.1007/s00238-008-0304-5

Cited by 23 publications

(18 citation statements)

References 22 publications

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“…Local recurrence is frequent (20–30%) while lymph node and distant metastases are uncommon (11% and 3–11%, respectively) . Only two cases with fatal outcome because of metastatic spread have been reported . The natural history of our case suggests that the neuroendocrine component, identified in every lymph node metastasis and recurrence, was mainly responsible for the aggressiveness of the tumor.…”

Section: Discussionmentioning

confidence: 63%

“…3,13,22,23 Only two cases with fatal outcome because of metastatic spread have been reported. 24,25 The natural history of our case suggests that the neuroendocrine component, identified in every lymph node metastasis and recurrence, was mainly responsible for the aggressiveness of the tumor. This differs from what has been reported in breast mucinous carcinomas, in which neuroendocrine differentiation is associated with a better prognosis because of more favorable microscopic and immunohistochemical parameters, and moreover it affects older patients.…”

Section: Discussionmentioning

confidence: 77%

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Recurrent primary cutaneous mucinous carcinoma with neuroendocrine differentiation: case report and review of the literature

Miquelestorena-Standley

Dujardin

Arbion

et al. 2014

J Cutan Pathol

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We report the case of a 60-year-old woman presenting with primary cutaneous mucinous carcinoma (PCMC) with neuroendocrine differentiation, revealed by neuroendocrine tumor lymph node metastasis 7 years before identification of the skin tumor. Only five cases of PCMC with neuroendocrine differentiation have been reported to date. The frequency of this neuroendocrine component may be underestimated, as it can require immunohistochemistry for identification, rather than being obvious on initial histopathologic examination. In the case presented here, the prominent neuroendocrine component displayed the morphological features of a well-differentiated neuroendocrine tumor with expression of common neuroendocrine markers, strong expression of estrogen and progesterone receptors and low Ki67 proliferation index (5%). This case shows that not all primary cutaneous neuroendocrine carcinomas are Merkel cell carcinomas (MCCs). In addition to rare primary cutaneous carcinoid tumors, the diagnosis of PCMC with neuroendocrine differentiation must be considered, particularly when confronted by a mucinous tumor or lymph node metastases of neuroendocrine carcinoma of unknown origin. On the basis of this case, identification of a neuroendocrine component in a PCMC might be an adverse prognostic indicator of recurrence or of lymph node metastasis and should support wider excision margins of the tumor.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 77%

Recurrent primary cutaneous mucinous carcinoma with neuroendocrine differentiation: case report and review of the literature

Miquelestorena-Standley

Dujardin

Arbion

et al. 2014

J Cutan Pathol

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“…10 One case documented six local recurrences without metastasis over 30 years. 11 The mainstay of treatment is surgical excision, but remission has been achieved with the aromatase inhibitor Anastrozole in a metastatic estrogen receptor positive case.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Primary Mucinous Carcinoma of the Eyelid

Burris¹,

Raven²,

Rodríguez³

et al. 2017

Ophthalmic Plastic &Amp; Reconstructive Surgery

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The aim of this study is to report a case of bilateral primary mucinous carcinoma of the eyelids. This is a case report and literature review. A 71 year-old-female presented with primary mucinous carcinoma of the left upper eyelid, which was excised with Mohs surgery. One year later she developed primary mucinous carcinoma of the right upper eyelid, which was also treated Mohs surgery. Extensive workup was negative for evidence of an unknown primary carcinoma or metastasis. Primary mucinous carcinoma of the eyelids may occur as multifocal tumors, and bilateral disease is not necessarily indicative of metastatic disease.

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“…Nos patients ont bénéficié d'une exérèse large et les limites chirurgicales périphériques étaient saines. Le taux de récidive locale est de près de 50% [ 12 ] et les métastases à distance surviennent dans 2,7% [ 4 ]. Notre patient présente une forme classique de carcinome mucineux primitif cutané, traité avec succès par une exérèse élargie.…”

Section: Discussionunclassified

Carcinome mucineux primitif cutané: à propos de deux cas et d’une revue de la littérature

Souaf¹,

Ameurtesse²,

Debbagh³

et al. 2014

Pan Afr Med J

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Le carcinome mucineux primitif cutané est une tumeur annexielle rare, développée à partir des glandes sudoripares. Il se localise en générale à l'extrémité céphalique, surtout la région périorbitaire. Nous rapportons deux observations d'un carcinome mucineux primitif de la face et de la région axillaire, chez deux patients âgés de 60 ans. L’étude histologique montrait une prolifération tumorale dermohypodermique, faite de cellules organisées en cordons, en amas et en massif cribriformes, au sein d'une substance mucoïde. En immunohistochimie les cellules tumorales exprimaient la cytokératine 7, l'EMA et les récepteurs hormonaux. L'actine musculaire lisse a bien marqué les cellules myoépithéliales au niveau de la composante in situ dans un seul cas. Le carcinome mucineux primitif cutané est difficile à différencier d'une métastase mammaire ou digestive. La mise en évidence de carcinome in situ ou de cellules myoépithéliale est en faveur de l'origine cutanée primitive. C'est une tumeur à croissance lente, avec des métastases exceptionnelles. Le traitement est chirurgical et le taux de récidive est très élevé. Et à travers ces deux observations, les auteurs mettent en relief les principaux aspects cliniques, histologiques, thérapeutiques de cette entité avec une revue de la littérature.

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Primary mucinous carcinoma of the skin: a case of metastasis after 10 years of disease-free interval

Cited by 23 publications

References 22 publications

Recurrent primary cutaneous mucinous carcinoma with neuroendocrine differentiation: case report and review of the literature

Recurrent primary cutaneous mucinous carcinoma with neuroendocrine differentiation: case report and review of the literature

Bilateral Primary Mucinous Carcinoma of the Eyelid

Carcinome mucineux primitif cutané: à propos de deux cas et d’une revue de la littérature

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