Primary mucosa-associated lymphoid tissue lymphoma in fallopian tubes: A case report and literature review

Abstract

Rationale: Mucosa-associated lymphoid tissue (MALT) lymphoma accounts for 7%–8% of newly diagnosed lymphomas. The stomach is the most common organ of origin (nearly 50% of MALT lymphomas). Only 2% of MALT lymphomas arise from the female genital tract, and most originated from uterus. We described a rare case of MALT lymphoma primarily arising from the fallopian tube. Patient concerns: A 26-year-old woman was brought into our gynecological clinic because of a history of irregular menstruation. The transvaginal ultrasonography revealed cystic masses in bilateral adnexa and both of them showed rich vasculature. Laboratory tests showed a high level (455.3 U/mL) of cancer antigen-125 (CA-125). Interventions: A laparoscopy was performed. Outcomes: Frozen section of the removed specimen revealed acute and chronic inflammation with abundant inflammatory cells infiltrating the mesenchyme. The right fallopian tube was removed. However, the final histological results showed inflammation accompanied by hyperplasia of lymphoid tissue. Immunohistochemistry staining were consistent with MALT lymphoma. The patient received the second surgery to remove the left fallopian tube and also confirmed the same pathology. Lessons: Gynecologists should be aware of cystic masses which showed rich vasculature and high level of CA-125.

An Unusual Case of Extranodal Marginal Zone Lymphoma Mimicking Abdominal Cocoon Syndrome in an Adolescent Patient

“…MALT lymphomas arising from the gynecologic tract are rare, with a limited number of reports in the medical literature. [5][6][7][8][9][10] Therefore, the natural history, etiology, and clinical associations of these tumors have not been well described.…”

“…4 The gynecologic tract is an extremely rare primary site of disease, with only sporadic cases reported in the fourth to eighth decades of life. [5][6][7][8][9][10] Here we present an unusual case of a MALT lymphoma arising from the gynecologic tract of a postpubescent pediatric patient.…”