Primary myeloid sarcoma of ovary: a case report and review of the literature

Abstract

Myeloid sarcoma (granulocytic sarcoma or chloroma) is a tumor formed by myeloid precursor cells in any localization other than the bone marrow. It can occur without underlying acute myeloid leukemia (AML) or other myeloid neoplasms. Herein, we present a forty-two-year-old female patient who underwent surgery because of a left adnexal mass. Microscopic examination of the specimen revealed cord-like arrangement of the tumor cells with a diffuse growth of small blue cells effacing the ovarian stroma. Adult granulosa cell tumor was in the differential given the scanty cytoplasm of the tumor and in fact was the diagnosis of the referring institution. Further microscopic evaluation with immunohistochemical analysis at our institution revised the diagnosis to myeloid sarcoma. Myeloid sarcoma is a difficult tumor to diagnose due to its rarity, especially in the absence of a history of leukemia, and correct tissue diagnosis is essential for its treatment.

Ovarian myeloid sarcoma with concurrent acute myeloid leukemia- A case report

“…4 Akyol et al described a 42 years old female patient with left ovarian myeloid sarcoma exhibiting positive immunoexpression with LCA, CD117, MPO, CD43, lysozyme, CD34, and CD68, in the absence of a history of leukemia. 8 Kahn et al presented a case of a 48 years old woman with MS involving the uterine corpus, fallopian tubes, and left ovary, after post-therapy clinical remission. 9 Ding et al also reported a 27 years old female, with a diagnosis of undifferentiated ovarian MS mass expressing focal CD45 and CD68 along with strong MPO and CD43 positive reaction.…”