Primary myelolipoma of the lung: a case of report and review of literature

Huang, Wenbin; Zhao, Yu; Yin, Xindao; Qi, Qiong

doi:10.5114/pjp.2012.31507

Cited by 10 publications

(9 citation statements)

References 8 publications

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“…But some patients with mediastinum myelolipoma presented with productive cough [9], the stiff neck [13], dull back pain and a cough [14] or central chest pain [15]. The patients with pulmonary myelolipoma complain of fever [16], productive cough [17,20] or intractable lumbago [19] and the others were asymptomatic (Table 1). There was no pain or cough in our case caused by the lesion, but it was detected from the chest radiography during a routine health check.…”

Section: Discussionmentioning

confidence: 99%

A bilateral neoplasm in chest: a case report and literature review

2014

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BackgroundMyelolipoma is a rare neoplasm composed of yellowish adipose tissue and reddish-brown tissue corresponding to hematopoietic or hemorrhages. It typically occurs in adrenal glands as a solitary, well-circumscribed mass, and the thoracic location is extremely unusual.Case presentationWe present a rare case who is a 54 years old male with bilateral Myelolipoma of the posterior mediastinum. He underwent the surgery via video-assisted thoracic surgery both sides interval 3 months. Histological examination showed both tumors consisted of mature fat tissue and hematopoietic tissue, including myeloid, erythroid, and megakaryocytic elements surrounded. We discussed the etiology, histopathology, differential diagnosis and recommended management of extra-adrenal myelolipoma and analyzed the features of the thoracic myelolipoma including mediastinal and pulmonary location.ConclusionsLiterature review showed 16 similar cases, with a 2/1 male/female ratio and a mean age of 58 years. Eight of sixteen cases were observed in the mediastinum and six of sixteen cases were displayed in the pulmonary and one showed on the chest wall. CT and MRI scans are able to indicate the presence of extra-adrenal myelolipoma. Pathological analysis is an effective method to clarify the diagnosis. Observation and surgery are two regular treatment methods. Small, asymptomatic tumors should be monitored, while large tumors that cause unendurable symptoms may be removed by surgery.

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Section: Discussionmentioning

confidence: 99%

A bilateral neoplasm in chest: a case report and literature review

2014

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“…Etiology of myelolipoma is still not entirely clarified. More theories concerning formation of this lesion exist, reporting possible myelolipoma development from embryonic mesenchymal cells originating from adrenal gland, emboli derived from hematogenous bone marrow, reticuloendothelial cell metaplasia and proliferation of hematopoietic stem cells [1] , [2] , [3] , [4] , [6] , [8] .…”

Section: Discussionmentioning

confidence: 99%

“…Color depends on the amount of lipid component and hematopoietic elements [3] . Microscopically, myelolipomas are described as tumors composed of mature fatty tissue and hematopoietic tissue, including myeloid, erythroid, megakaryocytic cells, lymphocytes with possible finding of hemorrhage, bone segments, cartilage and calcifications in the tumor [8] , [9] , [11] .…”

Section: Discussionmentioning

confidence: 99%

“…Myelolipoma is a lesion composed of mature fatty tissue and hematopoietic elements [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] . It represents a rare finding, especially in sites other than adrenal gland, such as lungs, mediastinum, thoracic spine, kidney, presacral and perirenal area, stomach, thyroid gland, liver, nasal cavity, bone, bronchi [1] , [2] , [3] , [4] , [5] , [7] , [8] , [9] , [10] . Its behavior is benign in nature [1] , which usually results in accidental revelation of the tumor during autopsy or during imaging procedures [1] , [3] , [6] .…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary myelolipoma containing osseous tissue: An unexpected finding at autopsy

Mašić

Vučić

Seiwerth

2017

Respiratory Medicine Case Reports

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Pulmonary myelolipoma is a very rare benign tumor composed of mature adipose tissue and hematopoietic elements such as erythroid, myeloid and megakaryocytic. It usually represents accidental finding during autopsy or chest imaging, since most cases are asymptomatic. Larger masses can lead to hemorrhage, chest pain and chest organ compression. We present a case of incidental finding of pulmonary myelolipoma during the autopsy of an 83- year old woman who died of abdominal aortic rupture. In the right lower lung lobe, solitary, well-circumscribed yellow-brown nodule which was 3 cm in its longest diameter was found. Pathohistological analysis revealed tumor composed of mature adipose tissue and hematopoietic cells (myeloid cells, megakaryocytes, erythroid cells) with fragments of mature bone tissue. Differential diagnosis of pulmonary myelolipoma includes lipoma, liposarcoma, hamartoma, phlebangioma, teratoma and extramedullary hematopoiesis. In majority of cases, tumor removal is not necessary, however, larger lesions should be surgically removed. No cases of malignant transformation or recurrence have so far been reported in the literature.

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“…Moreover, the chromosomal translocation (3;21)(q25;p11) has been detected in myelolipomas in patients with hematological malignancies, which has led to the speculation of bone marrow origin of these tumors [15]. Extra-adrenal myelolipomas have been documented in the mediastinum, lung, thoracic spine, liver mesentery, spleen, kidney and pelvis [16, 17, 18, 19, 20, 21]. They have been noted to be more common in women [22].…”

Section: Discussionmentioning

confidence: 99%

Giant Adrenal Myelolipoma Masquerading as Heart Failure

Joy

Marak²,

Nashed

et al. 2014

Case Rep Oncol

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Adrenal myelolipomas are rare benign tumors of the adrenal cortex composed of adipose and hematopoietic cells. They have been postulated to arise from repeated stimulation by stress, inflammation and ACTH oversecretion. Myelolipomas are usually detected incidentally on imaging and do not require any active intervention besides regular follow-up by imaging. However, myelolipomas may insidiously grow to large sizes and cause mass effects and hemorrhage. Timely diagnosis and surgical resection are curative and lifesaving.

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Primary myelolipoma of the lung: a case of report and review of literature

Cited by 10 publications

References 8 publications

A bilateral neoplasm in chest: a case report and literature review

A bilateral neoplasm in chest: a case report and literature review

Pulmonary myelolipoma containing osseous tissue: An unexpected finding at autopsy

Giant Adrenal Myelolipoma Masquerading as Heart Failure

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