Primary neuroendocrine carcinoma of the skin

Bayrou, O.; Avril, M.-F.; Charpentier, P; Caillou, Bernard; Guillaume, J; Prade, M

doi:10.1016/0190-9622(91)70027-y

Cited by 60 publications

(29 citation statements)

References 49 publications

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“…In a report comparing the clinical and microscopic features of six cases each of adenoid SCC and cutaneous angiosarcoma, it was observed that while all of the former were positive for cytokeratin and EMA (MUC1), the latter were uniformly negative. [77] EMA positivity was also reported in the neoplastic cells in tumor sections [78, 79] and percutaneous fine needle aspirates of primary and metastatic lesions of cutaneous Merkel cell carcinoma (MCC). [80]…”

Section: Mucin Expression In Malignant Neoplasms Arising In the Skinmentioning

confidence: 99%

Role of mucins in the skin during benign and malignant conditions

Chakraborty¹,

Bonthu²,

Swanson³

et al. 2011

Cancer Letters

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Skin related diseases comprise a major health challenge to the practicing physician, and constitute a significant psychological, social and financial burden to the society. Further, skin cancer, especially non-melanoma skin cancer is currently the leading type of malignancy in the Western world. Given the huge burden of skin diseases, there is growing emphasis on understanding their pathophysiology, and towards their early detection. Mucins are high molecular weight O- and N-linked glycoproteins that have emerged in recent years as important molecules in maintaining health and in promoting or protecting against inflammation and cancer. They have also begun to emerge as highly specific diagnostic and prognostic markers and novel therapeutic targets in several malignant disorders. However, their role in cutaneous pathologies has remained largely obscured. The present review provides the expression patterns and proposed role of mucins in the healthy skin and various benign and malignant skin diseases. The review has immense clinical significance as the availability of highly specific reagents including monoclonal antibodies against mucins makes them extremely attractive targets for specific diagnosis and/or immunotherapy of benign and malignant cutaneous diseases.

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Section: Mucin Expression In Malignant Neoplasms Arising In the Skinmentioning

confidence: 99%

Role of mucins in the skin during benign and malignant conditions

Chakraborty¹,

Bonthu²,

Swanson³

et al. 2011

Cancer Letters

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“…That epidermal melanocytic hyperplasia overlying trichoblastomas is not specific to this entity is evident by its occurrence in association with other epithelial and mesenchymal tumors; including fibrous papule, angiofibroma, plexiform neurofibroma, and Merkel cell carcinoma. [9][10][11] Epidermal melanocytic hyperplasia is distinct from melanocytic colonization, which is occasionally seen in various nonmelanocytic tumors [12][13][14][15][16] or maybe an essential component of the lesion as in melanocytic matricoma. 17 Melanocytic colonization was beyond the scope of this study but in a few cases for which staining for melanocytic markers was available, occasional intratumoral melanocytes were present.…”

Section: Discussionmentioning

confidence: 99%

Melanocytic Hyperplasia in the Epidermis Overlying Trichoblastomas in 100 Randomly Selected Cases

Omoush

Konstantinova²,

Michal³

et al. 2016

The American Journal of Dermatopathology

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One hundred cases of trichoblastomas (large nodular, small nodular, cribriform, lymphadenoma, and columnar) were randomly selected and studied for the presence of melanocytic hyperplasia in the epidermis overlying the tumors, which was defined as foci of increased melanocytes in the basal layer of the epidermis (more than 1 per 4 basal keratinocytes). Focal melanocytic hyperplasia was detected in a total of 22 cases of trichoblastoma (22%), and this phenomenon was most frequently seen in columnar trichoblastoma (7 cases), followed by large nodular trichoblastoma (5 cases). The mechanism of epidermal melanocytic hyperplasia overlying trichoblastoma is unclear. Ultraviolet may be a contributing factor, as focal melanocytic hyperplasia was also detected in one-third of cases in the epidermis overlying uninvolved skin, usually associated with solar elastosis. This is further corroborated by the occurrence of the lesions predominantly on the face. Melanocytic hyperplasia overlying trichoblastoma appears to have no impact on the clinical appearance of the lesion and is recognized only microscopically. In an adequate biopsy specimen containing at least part of trichoblastoma, it should not cause any diagnostic problems.

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“…The most common tumor associated with MCC is squamous cell carcinoma which is encountered in about 10% of cases. 8,9,14,17–20 This association was either in the form of squamous cell carcinoma in situ overlying the MCC 8 or in the form of infiltrating squamous cell carcinoma admixed with the MCC. 9,14,17,18 The association of BCC with MCC is a rarer occurrence; however, it is documented.…”

Section: Discussionmentioning

confidence: 99%

“…8,9,14,17–20 This association was either in the form of squamous cell carcinoma in situ overlying the MCC 8 or in the form of infiltrating squamous cell carcinoma admixed with the MCC. 9,14,17,18 The association of BCC with MCC is a rarer occurrence; however, it is documented. 14,17–19,21,22 Cerroni et al 18 reported a case presenting with MCC, SCC and BCC arising at the same site.…”

Section: Discussionmentioning

confidence: 99%

Basal cell carcinoma with progression to metastatic neuroendocrine carcinoma

2010

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Merkel cell carcinoma (MCC) or primary cutaneous neuroendocrine carcinoma is a malignant tumor considered to demonstrate differentiation towards Merkel cells that are present at the base of the epidermis or around the apical end of some hair follicles and are thought to play a yet uncertain role in sensory transduction. Here we present the case of a 54- year old female with a basal cell carcinoma (BCC) of the skin with neuroendocrine features (positivity for chromogranin) that has evolved during multiple recurrences and radiotherapy into a high-grade neuroendocrine carcinoma with morphological and immunohistochemical features of MCC (trabecular and nesting arrangement, positivity for chromogranin, cytokeratin 20, neuron specific enolase, and also neurosecretory granules on electron microscopy). The progression from a chromogranin positive basal cell carcinoma of the skin, to a high-grade neuroendocrine carcinoma demonstrates the potential for cross differentiation among skin tumors.

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Primary neuroendocrine carcinoma of the skin

Cited by 60 publications

References 49 publications

Role of mucins in the skin during benign and malignant conditions

Role of mucins in the skin during benign and malignant conditions

Melanocytic Hyperplasia in the Epidermis Overlying Trichoblastomas in 100 Randomly Selected Cases

Basal cell carcinoma with progression to metastatic neuroendocrine carcinoma

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