Primary Neuroendocrine Carcinoma of the Larynx: A Case Report

Divya, Gupta; Jayamohanan, Hridya; Smitha, N V; Anoop, R; Nambiar, Ajit; Thankappan, Krishnakumar; Pavithran, Keechilat

doi:10.1007/s12070-020-02060-z

Cited by 3 publications

(2 citation statements)

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“…NECs are a group of rare and aggressive cancers that originate from neuroendocrine cells in various parts of the body [ 4 ]. These tumors can develop in a range of organs, including the lungs, gastrointestinal tract, pancreas, and other areas where neuroendocrine cells are present [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, its clinicopathological features remain incompletely characterized. The larynx is the most frequent site for NECs in the head and neck region and poses significant challenges due to their tendency to metastasize extensively, leading to a generally unfavorable prognosis [ 4 ]. Significantly, it is essential to note that the base of the tongue is recognized as a subsite of the oropharynx while the anterior two-thirds of the tongue have been defined as parts of the oral cavity [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Small Cell Non-keratinizing Neuroendocrine Carcinoma Involving the Larynx and the Base of the Tongue: A Rare Case With a Locally Aggressive Spread

Patil,

Jain,

Wadhwa

et al. 2024

Cureus

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Squamous cell carcinoma is the most predominant type of malignancy in the head and neck region with neuroendocrine carcinomas (NECs) being a rare occurrence. Here we report a rare case of small cell non-keratinizing NEC (WHO grade 3), TNM (tumor, node, and metastasis) stage T3N1M0, involving the larynx and the base of the tongue, in a 54-year-old male patient, demonstrating its rarity in an uncommon anatomical site and an aggressive and relatively uncommon pattern of spread for this tumor, over a period of two months. NECs in the head and neck region, especially those affecting the larynx and the posterior third of the tongue, remain exceedingly rare, comprising only a small fraction of malignancies in this region. The aggressive nature and distinct pattern of spread observed in this case underscore the importance of recognizing such unusual presentations for appropriate diagnosis and management. Given the rarity of this tumor type, a comprehensive understanding of its clinicopathological features is essential for guiding effective treatment strategies. We also discuss the treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%