Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature

Angouridakis, Nikolaos; Goudakos, John; Karayannopoulou, Georgia; Triaridis, Stefanos; Nikolaou, Angelos; Markou, Konstantinos

doi:10.1002/hed.22955

Cited by 7 publications

(16 citation statements)

References 20 publications

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“…This shows a slightly lower male preponderance compared to the profile of laryngeal cancers as a whole, which the American Cancer Society reports occurs at a ratio of 4.5:1 1 and is the 11th most common cancer in men . This sex disparity is thought to be a consequence of tobacco and alcohol consumption practices, which case reports indicate may be a risk factor for neuroendocrine tumors, sarcomas, and melanomas . The sex disparity was less apparent in minor salivary gland tumors, which do not seem to be linked to alcohol and tobacco use .…”

Section: Discussionmentioning

confidence: 88%

Nonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery

et al. 2019

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Objectives: To analyze the incidence and clinical profile of nonsquamous cell (non-SCC) laryngeal carcinomas and to analyze the effect of surgery on survival.Study Design: A retrospective analysis of the National Cancer Database (2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014).Methods: Adult patients with non-SCC laryngeal cancers were divided into six major histological subtypes. A descriptive clinical profile was obtained for non-SCC patients, and multivariate regressions were performed to analyze the effect of surgery on survival within the non-SCC cohort.Results: We identified 878 cases of non-SCC laryngeal cancers, representing 1.02% of all malignant laryngeal cancers. Neuroendocrine tumors and bone/cartilage sarcomas made up the largest groups (37.02% and 32.35%, respectively). Metastasis (M) was higher in neuroendocrine tumors, representing 19.1% of those with known clinical M stages. Of those treated, the majority of patients with bone/cartilage sarcomas (80.9%) and minor salivary gland tumors (82.6%) received surgery as part of their treatment. Survival varied significantly based upon histology, with bone/cartilage sarcomas having the highest 5-year survival at 90.4%, and neuroendocrine tumors exhibiting the poorest 5-year survival at 25.7%. Multivariate analyses found surgery to be significantly associated with improved survival (hazard ratio: 0.679; 95% confidence interval: 0.472-0.976; P = 0.036). The specific surgical method (i.e., local excision vs. partial vs. total laryngectomy) did not have any effect on survival.Conclusion: Approximately 1% of all malignant laryngeal cancers are non-SCC in origin. At presentation, neuroendocrine tumors have the highest rate of distant metastasis and have the worst prognosis of the non-SCC cancers. Most non-SCC patients received surgery as part of their treatment regimen.

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Section: Discussionmentioning

confidence: 88%

Nonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery

et al. 2019

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“…The literature on NCL is fragmented over numerous case reports and series of small sample size, often with contradicting results, making it difficult to decide on an appropriate treatment strategy. Consequently, physicians facing these tumors often resort to treatment paradigms developed for better known neoplasms (eg, squamous cell carcinoma).…”

Section: Introductionmentioning

confidence: 99%

Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: A meta-analysis of 436 reported cases

et al. 2014

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“…Other varieties of malignancy found in larynx are verrucous carcinoma, spindle cell carcinoma, neuroendocrine tumors, lymphoepitheliomatous carcinoma, adenocarcinoma, and rare tumors (including sarcoma, lymphoma, adenocarcinoma and metastases). 34 Malignancy of larynx is a disease found more commonly in people from lower socio-economic class who are addicted to smoking and they being not conscious about health, present quite late to the hospital leading to poor treatment outcome in them. Therefore, it is desirable to educate them about this disease so that early diagnosis and treatment can make a difference in the morbidity and mortality of this disease.…”

Section: Discussionmentioning

confidence: 99%

Laryngeal malignancy: epidemiology and staging at the time of presentation in a rural population

Shariff

2018

Int J Otorhinolaryngol Head Neck Surg

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Background: Laryngeal cancer is one of the 10 leading causes of cancer in Indian men. Late presentation of the disease may worsen management outcomes. Consumption of tobacco and alcohol is associated with the development of laryngeal malignancy.Methods: A cross-sectional study was conducted in the Department of ENT, at Chamarajanagar Institute of Medical Sciences and Hospital, Chamarajanagar, India, for a period of 2 years 6 months from October 2014 to March 2017. During the study period, all cases that were diagnosed as Laryngeal malignancy by histopathology were included in the study group. The aim of this study is to determine the epidemiology, anatomical location of the tumor at presentation, clinical presentation and the stage of the tumor at the time of presentation. Results: Majority of patients were elderly male from lower socio-economic strata. The most common clinical presentations were change in voice, pain in throat, difficulty in swallowing, lump in neck and difficulty in breathing. Supraglottis (82%) was the most common anatomic location of tumor. 60% of the patients presented in stage III of the disease. All the cases were squamous cell carcinoma.Conclusions: Laryngeal malignancy is a relatively uncommon malignancy in general population but is more common in rural population especially in people belonging to lower socio-economic strata. Supraglottic malignancy is the most common anatomic location of laryngeal malignancy. Majority of the cases from rural population presented in an advanced stage of the disease.

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Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature

Abstract: Although neuroendocrine laryngeal tumors account for approximately 1% of all neoplasms in the larynx, its majority represents very aggressive tumors showing a capacity for metastasis and portending poor outcome.

Cited by 7 publications

References 20 publications

Nonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery

Nonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery

Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: A meta-analysis of 436 reported cases

Laryngeal malignancy: epidemiology and staging at the time of presentation in a rural population

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